Adiposity trajectory and its associations with plasma adipokine levels in children and adolescents-A prospective cohort study

Abstract Background: Anterior knee pain (AKP) is a common limitation to children’s participation in social and physical activities. Therefore, to prevent the occurrence and protraction of AKP, it is crucial to identify risk factors. The purpose of this study was to clarify the factors associated with the occurrence and protraction of AKP in children and adolescents. Method: A three-year prospective cohort study was conducted with children and adolescents aged 8–14 in Japan. We recorded the occurrence of AKP, heel buttock distance, straight leg raising angle (SLRA), dorsiflexion angle of the ankle joint, and the Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS). Logistic regression analysis was performed to calculate the odds ratio (OR) for each predicted risk factor for the occurrence and protraction of AKP among subjects without AKP at baseline. Results: We recruited 1,254 children and adolescents for the present study, and 1,133 children and adolescents who did not have AKP at baseline were included in the analysis. Six to nine percent of the subjects developed AKP annually. A high HSS Pedi-FABS score significantly predicted AKP occurrence (in 2017, OR 1.07, 95% CI 1.02−1.12, p = 0.003; in 2018, OR 1.05, 95% CI 1.01−1.10, p = 0.025). Of the participants, 32.9% developed chronic AKP during the follow-up period. When 8-year-old was used as a reference age, 13-year-old subjects (right side, OR 2.37, 95% CI, 1.00−5.61, p = 0.05) and 14-year-old subjects (right side, OR 2.57, 95% CI, 1.00−6.60, p = 0.049; left side, OR 6.32; 95% CI 1.33−30.00, p = 0.020) were at a significantly higher risk of AKP protraction. Conclusions: This study showed that a greater physical activity level was a risk factor for the onset of anterior knee pain in childhood. In addition, one-third of the children and adolescents developed chronic knee pain, and elderly adolescents were at a higher risk of protraction.

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Nutritional status of children and adolescents with cancer in Scotland: A prospective cohort study

Clinical Nutrition ESPEN ◽

10.1016/j.clnesp.2019.04.006 ◽

2019 ◽

Vol 32 ◽

pp. 96-106 ◽

Cited By ~ 6

Author(s):

Raquel Revuelta Iniesta ◽

Ilenia Paciarotti ◽

Isobel Davidson ◽

Jane M. McKenzie ◽

Mark F.H. Brougham ◽

...

Keyword(s):

Cohort Study ◽

Nutritional Status ◽

Children And Adolescents ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Nutritional Status Of Children

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Safety of Intranasal Quadrivalent Live Attenuated Influenza Vaccine (QLAIV) in Children and Adolescents: A Pilot Prospective Cohort Study in England

Drug Safety ◽

10.1007/s40264-015-0384-7 ◽

2016 ◽

Vol 39 (4) ◽

pp. 323-333 ◽

Cited By ~ 10

Author(s):

Rhian McNaughton ◽

Elizabeth Lynn ◽

Vicki Osborne ◽

Abigail Coughtrie ◽

Deborah Layton ◽

...

Keyword(s):

Cohort Study ◽

Influenza Vaccine ◽

Children And Adolescents ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Live Attenuated Influenza Vaccine

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Long-Term Effects on Renal Function in Children and Adolescents Due to Environmental Exposure to Lead-Results from an 11-Year Prospective Cohort Study

Journal of Toxicology and Risk Assessment ◽

10.23937/2572-4061.1510003 ◽

2015 ◽

Vol 1 (1) ◽

Author(s):

Recio-Vega R

Keyword(s):

Renal Function ◽

Cohort Study ◽

Children And Adolescents ◽

Environmental Exposure ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Long Term Effects

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Falls in paediatric Charcot-Marie-Tooth disease: a 6-month prospective cohort study

Archives of Disease in Childhood ◽

10.1136/archdischild-2018-314890 ◽

2018 ◽

Vol 104 (6) ◽

pp. 535-540 ◽

Cited By ~ 3

Author(s):

Rachel A Kennedy ◽

Kate Carroll ◽

Graham Hepworth ◽

Kade L Paterson ◽

Monique M Ryan ◽

...

Keyword(s):

Cohort Study ◽

Children And Adolescents ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Common Mechanism ◽

Charcot Marie Tooth ◽

Paediatric Hospital ◽

Charcot Marie Tooth Disease ◽

Injurious Falls ◽

Tooth Disease

ObjectiveTo prospectively study falls in children and adolescents with Charcot-Marie-Tooth disease (CMT).DesignProspective cohort study.SettingNeuromuscular outpatient clinic of a tertiary paediatric hospital.PatientsSixty children and adolescents (‘children’) aged 4–18 years, 30 with CMT and 30 typically developing (TD).Main outcome measuresFalls rate over 6 months and falls characteristics questionnaire.ResultsTwenty-two children with CMT reported falling at least once in 6 months compared with eight TD children (CMT 2819 (0–1915), TD 31 (0–6) total falls (range)). Detailed falls characteristics were collected from 242 individual falls (CMT 216, TD 26). Injurious falls were reported by 19 children with CMT (74 falls) compared with 2 TD children (3 falls), with cuts, grazes and bruising most common. No fractures were sustained and no child required hospitalisation. However, 12 injuries from falls in children with CMT required management by a healthcare provider, versus none in TD children. Tripping was the most common mechanism of falls in both groups. Age was the strongest predictor of falls (ρ=−0.53, p=0.006) with all children (CMT and TD) aged <7 years falling. Balance was the strongest impairment-related predictor of falls (ρ=−0.47, p=0.02). The conservative estimate of risk of falls in children and adolescents with CMT was 33 times higher than their TD peers (incidence rate ratio=32.8, 95% CI 10.2 to 106.0).ConclusionsChildren and adolescents with CMT fall more often than TD peers and sustain more injuries when they fall.

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Validation of Continuous Glucose Monitoring in Children and Adolescents With Cystic Fibrosis: A prospective cohort study

Diabetes Care ◽

10.2337/dc08-1925 ◽

2009 ◽

Vol 32 (6) ◽

pp. 1020-1022 ◽

Cited By ~ 49

Author(s):

S. M.P. O'Riordan ◽

P. Hindmarsh ◽

N. R. Hill ◽

D. R. Matthews ◽

S. George ◽

...

Keyword(s):

Cystic Fibrosis ◽

Cohort Study ◽

Children And Adolescents ◽

Prospective Cohort Study ◽

Continuous Glucose Monitoring ◽

Prospective Cohort ◽

Glucose Monitoring

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Trajectories of care for children and adolescents with psychosocial problems: a 3‐year prospective cohort study

Journal of Child Psychology and Psychiatry ◽

10.1111/jcpp.13137 ◽

2019 ◽

Vol 61 (5) ◽

pp. 556-564

Author(s):

Vera Verhage ◽

Danielle E.M.C. Jansen ◽

Josue Almansa ◽

Charlotte Wunderink ◽

Hans Grietens ◽

...

Keyword(s):

Cohort Study ◽

Children And Adolescents ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Psychosocial Problems

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Predictors of physical activity levels in children and adolescents with cerebral palsy: clinical cohort study protocol

BMJ Open ◽

10.1136/bmjopen-2020-047522 ◽

2021 ◽

Vol 11 (9) ◽

pp. e047522

Author(s):

Christina Esmann Fonvig ◽

Jens Troelsen ◽

Ulrike Dunkhase-Heinl ◽

Jens Martin Lauritsen ◽

Anders Holsgaard-Larsen

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Cerebral Palsy ◽

Cohort Study ◽

Children And Adolescents ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Increased Risk ◽

Study Results

IntroductionChildren and adolescents with cerebral palsy may be trapped in a vicious circle of low physical fitness, resulting in deconditioning that causes a further decrease in physical activity (PA), a lower quality of life and an increased risk of developing non-communicable diseases. Therefore, establishing a healthy and active lifestyle during childhood is even more important for individuals with a disability. However, the factors that influence habitual PA in children and adolescents with cerebral palsy remain unknown.The present protocol outlines a prospective cohort study with the aim of investigating potential predictors of habitual PA in children and adolescents with cerebral palsy in order to provide evidence for optimising PA levels and associated overall health.Methods and analysisThis prospective cohort study will enrol participants with cerebral palsy between the ages of 8 and 15 years at Gross Motor Function Classification System levels I–III. Using a modified version of the International Classification of Functioning, Disability and Health model as a conceptual analytical framework, the analysis will be divided into six components and will provide predictors for habitual PA measured by accelerometry. The potential predictive variables are registry data on physical function (Danish Cerebral Palsy Follow-Up Programme); validated proxy-reported questionnaires on quality of life (Paediatric Quality of Life Inventory), overall health, pain and participation in daily activities (Paediatric Outcomes Data Collection Instrument) and supplementary questions regarding sleep, screen time and socioeconomic status.Ethics and disseminationThe project is approved by the Danish Data Protection Agency (19/16396) and has been declared not notifiable by the Regional Committee on Health Research Ethics, cf. Committee Act Art. 14, paragraph 1 (S-20192000-23). The study results will be published in international peer-reviewed journals, presented at international conferences, and published in a PhD dissertation.Trial registration numberNCT04614207.

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