Five years in vitro
 study of (poly vinyl alcohol/poly vinyl pyrrolidone/poly acrylic acid) hydrogel to mimic the knee joint meniscus

Objective: The objectives of this study were to prepare and characterize a buccal mucoadhesive patch using poly (vinyl alcohol) (PVA), poly (vinyl pyrrolidone) (PVP) as a mucoadhesive matrix, Eudragit S100 as a backing layer, and lidocaine HCl as a model drug.Methods: Lidocaine HCl buccal patches were prepared using double casting technique. Molecular interactions in the polymer matrices were studied using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry. Mechanical and mucoadhesive properties were measured using texture analyzer. In vitro permeation of lidocaine HCl from the patch was conducted using Franz diffusion cell.Results: Both of the free and lidocaine HCl patches were smooth and transparent, with good flexibility and strength. ATR-FTIR, DSC and X-ray diffractometry studies confirmed the interaction of PVA and PVP. Mechanical properties of matrices containing 60% PVP were significantly lower than those containing 20% PVP (*P<0.05). Mucoadhesive properties had a tendency to decrease with the concentration of PVP in the patch. The patch containing 60% PVP had significantly lower muco-adhesiveness than those containing 20% PVP (*P<0.05). In vitro permeation revealed that the pattern of lidocaine HCl permeation started with an initial fast permeation, followed by a slower permeation rate. The initial permeation fluxes follow the zero-order model of which rate was not affected by the PVP concentrations in the PVA/PVP matrix.Conclusion: Mucoadhesive buccal patches fabricated with PVA/PVP were successfully prepared. Incorporation of PVP in PVA/PVP matrix affected the strength of polymeric matrix and mucoadhesive property of patches.

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Synthesis, characterization, and their some chemical and biological properties of PVA/PAA/nPS hydrogel nanocomposites: Hydrogel and wound dressing

Journal of Bioactive and Compatible Polymers ◽

10.1177/0883911520921474 ◽

2020 ◽

Vol 35 (3) ◽

pp. 203-215

Author(s):

Mehmet Emin Diken ◽

Berna Koçer Kizilduman ◽

Begümhan Yilmaz Kardaş ◽

Enes Emre Doğan ◽

Mehmet Doğan ◽

...

Keyword(s):

Fourier Transform ◽

Acrylic Acid ◽

Infrared Spectra ◽

Vinyl Alcohol ◽

Fourier Transform Infrared ◽

Poly Vinyl Alcohol ◽

Seed Particles ◽

Fourier Transform Infrared Spectra ◽

Hydrogel Nanocomposites ◽

Poly Acrylic Acid

The nanocomposite hydrogels were prepared by dispersing of the nanopomegranate seed particles into poly(vinyl alcohol)/poly(acrylic acid) blend matrix in an aqueous medium by the solvent casting method. These hydrogels were characterized using scanning electron microscopy, Fourier transform infrared spectra, differential scanning calorimetry, and optical contact angle instruments. The nanopomegranate seed, blend, and hydrogel nanocomposites were tested for microbial activity. In addition, cytocompatibilities of these blend and hydrogel nanocomposites/composites were tested on human lymphocyte with in vitro MTS cell viability assays. Fourier transform infrared spectra revealed that esterification reaction took place among functional groups in the structure of poly(vinyl alcohol) and poly(acrylic acid). The hydrophilic properties of all hydrogels decreased with increasing nanopomegranate seed content. The mean diameters of the nanopomegranate seed particles were about 88 nm. Nanopomegranate seed particles demonstrated antibacterial properties against gram-positive bacteria, Staphylococcus aureus, and gram-negative bacteria, Escherichia coli. The lymphocyte viabilities increased after addition of nanopomegranate seeds into the polymer blend. The swelling behavior of blend and hydrogels was dependent on the cross-linking density created by the reaction between poly(vinyl alcohol)/poly(acrylic acid) blend and nanopomegranate seed. Scanning electron microscopy images were highly consistent with Fourier transform infrared spectra, differential scanning calorimetry, and antibacterial activity results.

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Nafion-Based Proton-Exchange Membranes Built on Cross-Linked Semi-Interpenetrating Polymer Networks between Poly(acrylic acid) and Poly(vinyl alcohol)

ACS Applied Materials & Interfaces ◽

10.1021/acsami.1c05662 ◽

2021 ◽

Author(s):

Abu Zafar Al Munsur ◽

Bon-Hyuk Goo ◽

Youngkwang Kim ◽

Oh Joong Kwon ◽

Sae Yane Paek ◽

...

Keyword(s):

Acrylic Acid ◽

Vinyl Alcohol ◽

Polymer Networks ◽

Proton Exchange Membranes ◽

Interpenetrating Polymer Networks ◽

Proton Exchange ◽

Poly Vinyl Alcohol ◽

Poly Acrylic Acid

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Multifunctional Coatings for Robotic Implanted Device

International Journal of Molecular Sciences ◽

10.3390/ijms20205126 ◽

2019 ◽

Vol 20 (20) ◽

pp. 5126 ◽

Cited By ~ 2

Author(s):

Caterina Cristallini ◽

Serena Danti ◽

Bahareh Azimi ◽

Veronika Tempesti ◽

Claudio Ricci ◽

...

Keyword(s):

Acrylic Acid ◽

Vinyl Alcohol ◽

Soft Tissues ◽

Functional Characterization ◽

Titanium Substrate ◽

Repair Process ◽

Chemical Imaging ◽

In Vitro Cytotoxicity ◽

Poly Vinyl Alcohol

The objective of this study was the preparation and physico-chemical, mechanical, biological, and functional characterization of a multifunctional coating for an innovative, fully implantable device. The multifunctional coating was designed to have three fundamental properties: adhesion to device, close mechanical resemblance to human soft tissues, and control of the inflammatory response and tissue repair process. This aim was fulfilled by preparing a multilayered coating based on three components: a hydrophilic primer to allow device adhesion, a poly(vinyl alcohol) hydrogel layer to provide good mechanical compliance with the human tissue, and a layer of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers. The use of biopolymer fibers offered the potential for a long-term interface able to modulate the release of an anti-inflammatory drug (dexamethasone), thus contrasting acute and chronic inflammation response following device implantation. Two copolymers, poly(vinyl acetate-acrylic acid) and poly(vinyl alcohol-acrylic acid), were synthetized and characterized using thermal analysis (DSC, TGA), Fourier transform infrared spectroscopy (FT-IR chemical imaging), in vitro cell viability, and an adhesion test. The resulting hydrogels were biocompatible, biostable, mechanically compatible with soft tissues, and able to incorporate and release the drug. Finally, the multifunctional coating showed a good adhesion to titanium substrate, no in vitro cytotoxicity, and a prolonged and controlled drug release.

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