Vascular activation in the histopathogenesis of Hodgkin's disease: Potential role of endothelial tissue factor in intravascular thrombosis and necrosis

Background A number of reports have studied associations between Hodgkin's disease and HLA. Some of them established correlation between several antigens and Hodgkin's disease, and others found no correlations. Methods The HLA DP locus was determined by the polymerase chain reaction method in 31 Hodgkin's disease patients and 58 healthy controls. Results No significant difference between patients and controls was noted. Conclusions Further investigations are needed to confirm the hypothesis of a possible role of the HLA complex as one of the factors involved in Hodgkin's disease.

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Potential role of activated factor VIII (FVIIIa) in FVIIa/tissue factor-dependent FXa generation in initiation phase of blood coagulation

International Journal of Hematology ◽

10.1007/s12185-019-02611-3 ◽

2019 ◽

Vol 109 (4) ◽

pp. 390-401 ◽

Cited By ~ 2

Author(s):

Shoko Furukawa ◽

Keiji Nogami ◽

Kenichi Ogiwara ◽

Midori Shima

Keyword(s):

Factor Viii ◽

Tissue Factor ◽

Blood Coagulation ◽

Potential Role ◽

Initiation Phase

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Successful marrow transplantation for acute myelocytic leukemia following therapy for Hodgkin's disease.

Journal of Clinical Oncology ◽

10.1200/jco.1988.6.10.1558 ◽

1988 ◽

Vol 6 (10) ◽

pp. 1558-1561 ◽

Cited By ~ 27

Author(s):

R B Geller ◽

G B Vogelsang ◽

J R Wingard ◽

A M Yeager ◽

W H Burns ◽

...

Keyword(s):

Hodgkin's Disease ◽

Marrow Transplantation ◽

Hematologic Malignancy ◽

Hodgkin’S Disease ◽

Combined Modality Therapy ◽

Intensive Therapy ◽

Acute Myelocytic Leukemia ◽

Myelocytic Leukemia ◽

Histocompatibility Locus

Five patients with acute myelocytic leukemia (AML) after combined modality therapy for Hodgkin's disease (HD) were treated with cyclophosphamide and busulfan followed by bone marrow transplantation (BMT). Four patients received allogeneic transplants from histocompatibility locus antigen (HLA)-compatible siblings and the fifth patient received an autologous marrow treated with 4-hydroperoxycyclophosphamide. Two patients died of complications of acute graft-v-host disease (GVHD) despite prophylaxis with either low-dose cyclophosphamide or cyclosporine. The remaining three patients were alive and disease-free 382, 617, and 620 days after transplant. These initial results are encouraging and more patients with treatment-related AML need to be evaluated with both allogeneic and autologous BMT to fully elucidate the potentially curative role of this intensive therapy in an otherwise fatal hematologic malignancy.

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Lung Cancer After Hodgkin’s Disease: A Nested Case-Control Study of the Relation to Treatment

Journal of Clinical Oncology ◽

10.1200/jco.2001.19.6.1610 ◽

2001 ◽

Vol 19 (6) ◽

pp. 1610-1618 ◽

Cited By ~ 99

Author(s):

A. J. Swerdlow ◽

M. J. Schoemaker ◽

R. Allerton ◽

A. Horwich ◽

J. A. Barber ◽

...

Keyword(s):

Lung Cancer ◽

Hodgkin's Disease ◽

Case Control Study ◽

Hodgkin’S Disease ◽

Case Control ◽

Lung Cancers ◽

Number Of Cycles ◽

Nested Case Control ◽

Control Study

PURPOSE: To investigate the causes of the raised risk of lung cancer in patients who have had Hodgkin’s disease, and in particular the relationship to treatment. PATIENTS AND METHODS: A nested case-control study was conducted within a cohort of 5,519 patients with Hodgkin’s disease treated in Britain during 1963 through 1993. For 88 cases of lung cancer and 176 matched control subjects, information on treatment and other risk factors was extracted from hospital case-notes, and odds ratios for lung cancer in relation to these factors were calculated. RESULTS: Risk of lung cancer was borderline significantly greater in patients treated with mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) chemotherapy than those who did not receive this treatment (relative risk [RR] = 1.66; 95% confidence interval [CI], 0.99 to 2.82), and increased with number of cycles of MOPP (P = .07). Exclusion of lung cancers for which histologic confirmation was not available strengthened these associations (RR = 2.41; 95% CI, 1.33 to 4.51; P = .004 for any MOPP and P = .007 for trend with number of cycles of MOPP). Risks were not raised, however, after chlorambucil, vinblastine, procarbazine, and prednisone treatment. There was evidence that the raised risk of lung cancer occurring in relation to radiotherapy was restricted to histologies other than adenocarcinoma. CONCLUSION: The results suggest that MOPP chemotherapy may lead to elevated risk of lung cancer, at least in certain subgroups of patients. The role of chemotherapy in the etiology of lung cancer after Hodgkin’s disease deserves further investigation.

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