Maternal serum activin A and inhibin A in trisomy 18 pregnancies at 10-14 weeks

2001 ◽  
Vol 21 (7) ◽  
pp. 571-574 ◽  
Author(s):  
Kevin Spencer ◽  
Adolfo W. Liao ◽  
Charas Y. T. Ong ◽  
Nicola J. Flack ◽  
Kypros H. Nicolaides
Keyword(s):  
Activin A ◽  
Maternal Serum ◽  
Trisomy 18 ◽  
Inhibin A

scholarly journals A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-alphaC and follistatin during pregnancy

1998 ◽  
Vol 13 (12) ◽  
pp. 3530-3536 ◽  
Author(s):  
P. A. Fowler ◽  
L. W. Evans ◽  
N. P. Groome ◽  
A. Templeton ◽  
P. G. Knight
Keyword(s):  
Longitudinal Study ◽  
Activin A ◽  
Maternal Serum ◽  
Inhibin B ◽  
Inhibin A

Maternal serum inhibin-A and activin-A levels in the first trimester of pregnancies developing pre-eclampsia

2008 ◽  
Vol 32 (5) ◽  
pp. 622-626 ◽  
Author(s):  
K. Spencer ◽  
N. J. Cowans ◽  
K. H. Nicolaides
Keyword(s):  
First Trimester ◽  
Activin A ◽  
Maternal Serum ◽  
Inhibin A

scholarly journals Second trimester levels of maternal serum total activin A and placental inhibin/activin alpha and betaA subunit messenger ribonucleic acids in Down syndrome pregnancy

1998 ◽  
pp. 425-429 ◽  
Author(s):  
GM Lambert-Messerlian ◽  
S Luisi ◽  
P Florio ◽  
V Mazza ◽  
JA Canick ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Placental Tissue ◽  
Normal Karyotype ◽  
Activin A ◽  
Maternal Serum ◽  
Mrna Levels ◽  
Serum Samples ◽  
Inhibin A ◽  
Ribonucleic Acids ◽  
Gapdh Mrna

OBJECTIVES: Previous data have shown that inhibin A (alpha/betaA) is increased about twofold in maternal serum samples from Down syndrome pregnancy. Our objectives were to determine whether activin A (betaA/betaA) was similarly increased in maternal serum from pregnancies affected with fetal Down syndrome, and to investigate whether increased expression of each inhibin/activin subunit occurred in placental tissue from cases of fetal Down syndrome. DESIGN AND METHODS: Maternal serum total activin A levels were measured in 20 cases of fetal Down syndrome and 100 unaffected pregnancy samples. In addition, analysis of inhibin/activin alpha and betaA subunit mRNA levels was performed in placental tissue extracts from six cases of fetal Down syndrome and six tissues with a normal karyotype. RESULTS: The median total activin A level in the Down syndrome cases was 0.82 MoM (multiples of the median); values did not differ significantly (P = 0.36, Mann-Whitney U analysis) from those in unaffected pregnancies. The inhibin alpha subunit/GAPDH mRNA ratio, but not that of betaA subunit/GAPDH mRNA, was significantly greater (P < 0.01, ANOVA) in placental tissue from Down syndrome than in control placental tissue. CONCLUSIONS: Unlike inhibin A, activin A is not significantly increased in Down syndrome relative to unaffected pregnancy. Furthermore, increased amounts of maternal serum inhibin A in Down syndrome pregnancy probably result from increased placental expression of inhibin alpha, but not betaA, subunit.

Maternal serum activin A, inhibin A, and follistatin in pregnancies with appropriately grown and small-forgestational-age fetuses classified by umbilical artery Doppler ultrasound

2002 ◽  
Vol 186 (2) ◽  
pp. 283-287 ◽  
Author(s):  
Catherine S. Bobrow ◽  
Robert P. Holmes ◽  
Shanthi Muttukrishna ◽  
Ajitha Mohan ◽  
Nigel Groome ◽  
...  
Keyword(s):  
Doppler Ultrasound ◽  
Umbilical Artery ◽  
Activin A ◽  
Maternal Serum ◽  
Inhibin A ◽  
Umbilical Artery Doppler

scholarly journals Inhibin A and Activin A in the First Trimester of Human Pregnancy

1997 ◽  
Vol 82 (5) ◽  
pp. 1557-1560 ◽  
Author(s):  
Mary Birdsall ◽  
William Ledger ◽  
Nigel Groome ◽  
Hossam Abdalla ◽  
Shanthi Muttukrishna
Keyword(s):  
First Trimester ◽  
Activin A ◽  
Maternal Serum ◽  
Corpora Lutea ◽  
Specific Enzyme ◽  
Inhibin A ◽  
Human Pregnancy ◽  
First Trimester Of Pregnancy ◽  
Donor Egg ◽  
High Concentrations

Abstract Recent studies show that high concentrations of inhibin A and activin A are present in the maternal serum throughout human pregnancy. The aim of this study was to determine whether the corpus luteum produces significant quantities of inhibin A and activin A during the first trimester of pregnancy. This prospective study examined two groups of women who had blood samples taken from 5–12 weeks gestation. One group consisted of 14 women with donor egg pregnancies (8 singletons and 6 multiples) who did not have corpora lutea, and the other group consisted 5 women with spontaneous pregnancies who had corpora lutea. Inhibin A and activin A were measured at weekly intervals using specific enzyme immunoassays. All pregnancies progressed to term, with healthy babies being delivered. Maternal serum concentrations of inhibin A significantly increased throughout the study period in the donor egg pregnancies (P &lt; 0.001) and the control pregnancies (P &lt; 0.001). Circulating concentrations of activin A also increased significantly in both the spontaneous and donor egg pregnancies (P &lt; 0.001) during the study period. However, the concentrations of inhibin A and activin A in the first trimester of human pregnancy were not significantly different in the women with or without corpora lutea, suggesting a fetoplacental origin. Multiple donor egg pregnancies were found to have higher concentrations of inhibin A (P &lt; 0.001) and activin A (P &lt; 0.05) compared with singleton donor egg pregnancies, which also supports a placental source.

Sign in / Sign up

Export Citation Format

Share Document