A comparison of prenatal versus postnatal karyotyping for the investigation of intrauterine fetal death after the first trimester of pregnancy

To study defects and chromosomal abnormalities of the fetus, we retrospectively analyzed results of comprehensive dynamic survey of 26,404 pregnant women aged 18-50 years old at 6 to 40 weeks of pregnancy. Of them, 25,956 (98.3%) women had physiological course of pregnancy, 448 (1.7%) women had abnormal pregnancy. For the diagnosis of fetal defects, we carried out ultrasound, biochemical, invasive and cytogenetic studies. The results of study showed that the majority of fetal defects and pathological course of pregnancy was noted in women at the age of 21-25 years old, since at this age period women have the highest number of pregnancies. At the older age, we noted a gradual decrease in the number of pregnant women, as well as the number of abnormalities of the fetus. Based on the analysis of the results obtained, we have developed an algorithm for early fetal ultrasound examination. In order to exclude non-developing pregnancy and intrauterine fetal death, as well as for early diagnosis of fetal defects, we recommend screening women in the first trimester of pregnancy.

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Can a temporary isolated fetal megacystis during first trimester result in unexplained intrauterine fetal death at third trimester?: a case report and review of the literature

Perinatal Journal ◽

10.2399/prn.12.0202006 ◽

2012 ◽

Vol 20 (2) ◽

pp. 68-71

Author(s):

Servet Hacıvelioğlu

Keyword(s):

Case Report ◽

Fetal Death ◽

First Trimester ◽

Intrauterine Fetal Death ◽

Review Of The Literature ◽

Third Trimester

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Multicystic encephalomalacia after first-trimester intrauterine fetal death in monochorionic twins

American Journal of Obstetrics and Gynecology ◽

10.1016/s0002-9378(03)00824-x ◽

2004 ◽

Vol 190 (2) ◽

pp. 563-565 ◽

Cited By ~ 34

Author(s):

Joshua L Weiss ◽

Jane Cleary-Goldman ◽

Kurenai Tanji ◽

Nancy Budorick ◽

Mary E D'Alton

Keyword(s):

Fetal Death ◽

First Trimester ◽

Intrauterine Fetal Death ◽

Monochorionic Twins

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Gestational and congenital syphilis in a municipality in Brazil between 2014 and 2018

Jornal Brasileiro de Doenças Sexualmente Transmissíveis ◽

10.5327/dst-2177-8264-201931402 ◽

2019 ◽

Vol 31 (4) ◽

pp. 112-117 ◽

Cited By ~ 1

Author(s):

Patricia Simon da Silva ◽

Cassandra Severo Amaral Vieira ◽

Ludmila Mourão Xavier Gomes ◽

Thiago Luis de Andrade Barbosa

Keyword(s):

Infectious Disease ◽

Information System ◽

Fetal Death ◽

Congenital Syphilis ◽

First Trimester ◽

Simple Linear Regression ◽

Neonatal Infections ◽

Time Series Study ◽

First Trimester Of Pregnancy ◽

Series Study

Introduction: Syphilis is an infectious disease that can cause congenital syphilis when it affects pregnant women, resulting in malformation of the fetus, miscarriage, or fetal death. Unlike many neonatal infections, congenital syphilis is considered a preventable perinatal cause, because it can be diagnosed and treated early during pregnancy. Objective: To analyze the reports of cases of gestational syphilis and congenital syphilis registered in Foz do Iguaçu City, Paraná State, between 2014 and 2018. Methods: This is a time-series study on the trend of cases recorded in the Notification Diseases Information System. The simple linear regression model was adopted to verify the trend of deaths in the analyzed period. Results: A total of 324 reports of gestational syphilis and 137 cases of congenital syphilis were evidenced in the study period. Regarding cases of gestational syphilis, 45.9% were diagnosed during the first trimester of pregnancy, 74.6% were treated with penicillin, and 24.3% were classified as primary syphilis. Roughly 88.3% of cases of congenital syphilis were reported in children under the age of 7 days. A significant increase in the rate of detection of gestational syphilis was observed, representing an increase of 4.0 times (p=0.004) in the years analyzed, and the risk of congenital syphilis increased 5.8 times (p=0.003) in the same period. Conclusion: The magnitude of gestational and congenital syphilis is a warning that indicates the need for actions and strategies to reduce cases of gestational syphilis and vertical transmission of syphilis.

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Persistence of SARS-CoV-2 in the first trimester placenta leading to vertical transmission and fetal demise from an asymptomatic mother

10.1101/2020.08.18.20177121 ◽

2020 ◽

Cited By ~ 1

Author(s):

Prajakta Shende ◽

Pradip Gaikwad ◽

Manisha Gandhewar ◽

Pawankumar Ukey ◽

Anshul Bhide ◽

...

Keyword(s):

Respiratory Tract ◽

Amniotic Fluid ◽

Vertical Transmission ◽

Early Pregnancy ◽

Fetal Death ◽

Clinical Course ◽

First Trimester ◽

Intrauterine Fetal Death ◽

Fetal Membranes ◽

Fetal Demise

Coronaviruses infect the respiratory tract and are known to survive in these tissues during the clinical course of infection. However, how long can SARS-CoV-2 survive in the tissues is hitherto unknown. Herein, we report a case where the virus is detected in the first trimester placental cytotrophoblast and syncytiotrophoblasts five weeks after the asymptomatic mother cleared the virus from the respiratory tract. This first trimester placental infection was vertically transmitted as the virus was detected in the amniotic fluid and fetal membranes. This congenitally acquired SARS-CoV-2 infection was associated with hydrops and fetal demise. This is the first study providing concrete evidences towards persistent tissue infection of SARS-CoV-2, its congenital transmission in early pregnancy leading to intrauterine fetal death.

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Catheter Directed Thrombolysis for Deep Vein Thrombosis during the First Trimester of Pregnancy: Two Case Reports

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2008.58.2.127 ◽

2008 ◽

Vol 58 (2) ◽

pp. 127

Author(s):

Kum Rae Kim ◽

Won Kyu Park ◽

Jae Woon Kim ◽

Woo Hyung Kwun ◽

Bo Yang Suh ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Case Reports ◽

First Trimester ◽

Vein Thrombosis ◽

Catheter Directed Thrombolysis ◽

First Trimester Of Pregnancy ◽

Deep Vein

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FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

Acta Endocrinologica ◽

10.1530/acta.0.0410123 ◽

1962 ◽

Vol 41 (1) ◽

pp. 123-128 ◽

Cited By ~ 6

Author(s):

Pentti A. Järvinen ◽

Sykkö Pesonen ◽

Pirkko Väänänen

Keyword(s):

Hyperemesis Gravidarum ◽

First Trimester ◽

Control Group ◽

Before And After ◽

Daily Urine ◽

First Trimester Of Pregnancy ◽

The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

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