Reprint from Joslin's ‘Diabetes mellitus’ (12th ed) Chapter 12: Oral Hypoglycaemic Agents (by Leo Krall). Authors: A Marble, LP Krall, RF Bradley, AR Christlieb, JS Soeldner. Publisher: Lea & Febiger, 600 South Washington Square, Philadelphia, PA 19106-4198. Year of issue: 1993. Size: 185 × 260mm. No pages: 461. Cover: Softback

1993 ◽  
Vol 10 (6) ◽  
pp. 241-241
Author(s):  
W Alexander
Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2293-PUB ◽  
Author(s):  
VEERANNA KARADI ◽  
DILIP PAWAR ◽  
SARAH JABEEN ◽  
SANDEEP S. ◽  
SAPTARSHI BOSE ◽  
...  

2013 ◽  
Vol 16 (3) ◽  
pp. 276-283 ◽  
Author(s):  
G. E. C. Sun ◽  
B. J. Wells ◽  
K. Yip ◽  
R. Zimmerman ◽  
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pp. 2272-2282
Author(s):  
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Anand Koppad ◽  
Ameet Khatawkar ◽  
Savitri D Kabade ◽  
Afaq Ahmed

1962 ◽  
Vol 108 (454) ◽  
pp. 371-372
Author(s):  
Susanne Shafar

Former attempts to restore weight loss in psychiatric patients have included hyperalimentation (Weir Mitchell, 8) and sub-coma insulin therapy (Debenham et al., 2; Sargant and Craske, 5; Sullivan, 7). The aim of the present trial was to compare weight gains in a group of patients given repeated small doses of insulin with two other groups to whom oral hypoglycaemic agents were administered, and with a control group. The drugs used were tolbutamide and chlorpropamide, both of which are sulphonylureas used in the management of diabetes mellitus, and known to induce hypoglycaemia in non-diabetic subjects (Hoenig and Gittleson, 4; Cardonnet et al., 1; Garcia Reyes et al., 3). Pharmacologically there are no qualitative differences in their mode of action. Stowers et al., (6) found the half-life of tolbutamide to be 3·5 hours and that of chlorpropamide 34·5 hours. The prolonged action of chlorpropamide permits once daily dosage, but tolbutamide, being a shorter acting drug, was given in divided doses to maintain depression of blood sugar over the 24 hours.


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