Clinical correlates of the ability to consent to research participation in brain metastasis

2020 ◽  
Vol 29 (10) ◽  
pp. 1655-1661
Author(s):  
Adam Gerstenecker ◽  
Meredith Gammon ◽  
Dario Marotta ◽  
John Fiveash ◽  
Burt Nabors ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Research Participation ◽  
Clinical Correlates ◽  
Ability To Consent

scholarly journals Capacity to consent to research participation in adults with metastatic cancer: comparisons of brain metastasis, non-CNS metastasis, and healthy controls

2020 ◽  
Vol 7 (4) ◽  
pp. 439-445
Author(s):  
Kyler Mulhauser ◽  
Dario A Marotta ◽  
Adam Gerstenecker ◽  
Gabrielle Wilhelm ◽  
Terina Myers ◽  
...  
Keyword(s):  
Informed Consent ◽  
Brain Metastasis ◽  
Group Performance ◽  
Metastatic Cancer ◽  
Research Participation ◽  
Healthy Controls ◽  
Capacity To Consent ◽  
Cns Metastasis ◽  
The Brain ◽  
A Performance

Abstract Background To evaluate the ability of individuals with metastatic cancer to provide informed consent to research participation, we used a structured vignette-based interview to measure 4 consenting standards across 3 participant groups. Methods Participants included 61 individuals diagnosed with brain metastasis, 41 individuals diagnosed with non-CNS metastasis, and 17 cognitively intact healthy controls. All groups were evaluated using the Capacity to Consent to Research Instrument (CCRI), a performance-based measure of research consent capacity. The ability to provide informed consent to participate in research was evaluated across 4 consent standards: expressing choice, appreciation, reasoning, and understanding. Capacity performance ratings (intact, mild/moderate impairment, severe impairment) were identified based on control group performance. Results Results revealed that the brain metastasis group performed significantly lower than healthy controls on the consent standard of understanding, while both metastatic cancer groups performed below controls on the consent standard of reasoning. Both metastatic cancer groups performed similar to controls on the standards of appreciation and expressing choice. Approximately 60% of the brain metastasis group, 54% of the non-CNS metastasis group, and 18% of healthy controls showed impaired research consent capacity. Conclusions Our findings, using a performance-based assessment, are consistent with other research indicating that the research consent process may be overly cumbersome and confusing. This, in turn, may lead to research consent impairment not only in patient groups but also in some healthy adults with intact cognitive ability.

Research Participation Experiences of Informants of Suicide and Control Cases

Crisis ◽  
2010 ◽  
Vol 31 (5) ◽  
pp. 238-246 ◽  
Author(s):  
Paul W. C. Wong ◽  
Wincy S. C. Chan ◽  
Philip S. L. Beh ◽  
Fiona W. S. Yau ◽  
Paul S. F. Yip ◽  
...  
Keyword(s):  
Ethical Issues ◽  
Research Participation ◽  
Self Report ◽  
Initial Contact ◽  
Psychological Autopsy ◽  
Autopsy Study ◽  
The People ◽  
And Control ◽  
The Impact

Background: Ethical issues have been raised about using the psychological autopsy approach in the study of suicide. The impact on informants of control cases who participated in case-control psychological autopsy studies has not been investigated. Aims: (1) To investigate whether informants of suicide cases recruited by two approaches (coroners’ court and public mortuaries) respond differently to the initial contact by the research team. (2) To explore the reactions, reasons for participation, and comments of both the informants of suicide and control cases to psychological autopsy interviews. (3) To investigate the impact of the interviews on informants of suicide cases about a month after the interviews. Methods: A self-report questionnaire was used for the informants of both suicide and control cases. Telephone follow-up interviews were conducted with the informants of suicide cases. Results: The majority of the informants of suicide cases, regardless of the initial route of contact, as well as the control cases were positive about being approached to take part in the study. A minority of informants of suicide and control cases found the experience of talking about their family member to be more upsetting than expected. The telephone follow-up interviews showed that none of the informants of suicide cases reported being distressed by the psychological autopsy interviews. Limitations: The acceptance rate for our original psychological autopsy study was modest. Conclusions: The findings of this study are useful for future participants and researchers in measuring the potential benefits and risks of participating in similar sensitive research. Psychological autopsy interviews may be utilized as an active engagement approach to reach out to the people bereaved by suicide, especially in places where the postvention work is underdeveloped.

"Academic value of research participation by undergraduates": Comment on Coulter and on Daniel.

1987 ◽  
Vol 42 (3) ◽  
pp. 268-269 ◽  
Author(s):  
Bruce K. Britton
Keyword(s):  
Research Participation

Children's Perception of Research Participation as a Function of Trauma History

2007 ◽  
Author(s):  
Ann T. Chu ◽  
Anne P. Deprince ◽  
Kristin Weinzierl
Keyword(s):  
Research Participation ◽  
Trauma History

Patterns and clinical correlates of Anxiety Disorder Not Otherwise Specified in youth

2011 ◽  
Author(s):  
Kaitlin P. Gallo ◽  
Priya Korathu-Larson ◽  
Jonathan S. Comer
Keyword(s):  
Anxiety Disorder ◽  
Clinical Correlates ◽  
Not Otherwise Specified

Clinical correlates of fourteen- and six-cycles-per-second positive EEG spiking and family pathology.

1970 ◽  
Vol 76 (3, Pt.1) ◽  
pp. 403-412
Author(s):  
Irwin M. Greenberg
Keyword(s):  
Clinical Correlates

Substance misuse in first episode psychotic patients: sociodemographic, premorbid and clinical correlates. Data from the PICOS-Veneto study

2011 ◽  
Vol 38 (S 01) ◽  
Author(s):  
S Tosato ◽  
R Mazzoncini ◽  
A Lasalvia ◽  
C Bonetto ◽  
M Bertani ◽  
...  
Keyword(s):  
Substance Misuse ◽  
First Episode ◽  
Clinical Correlates

Brain metastasis from follicular thyroid carcinoma as first manifestation of the disease

2016 ◽  
Author(s):  
Rosa Marquez-Pardo ◽  
Lourdes Garcia-Garcia-Doncel ◽  
Baena-Nieto M Gloria ◽  
Manuel Cayon-Blanco ◽  
Rosario Lopez-Velasco ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma
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