Comparison of Propellant Processing by Cast‐Cure and Resonant Acoustic Mixing

We introduce catalytic organic synthesis by Resonant Acoustic Mixing (RAM): a mechanochemical methodology that does not require bulk solvent or milling media. Using as model reactions ruthenium-catalyzed ring-closing metathesis, ene-yne metathesis and copper-catalyzed sulfonamide-isocyanate coupling, we demonstrate RAM-based mechanochemical synthesis that is faster and operationally simpler than conventional ball milling. Moreover, the method can be readily scaled-up, as demonstrated by straightforward catalytic synthesis of the antidiabetic drug Tolbutamide from hundreds of milligrams to at least 10 grams, without any significant changes in reaction conditions.

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Simple, Scalable Mechanosynthesis of Metal-Organic Frameworks Using Liquid-Assisted Resonant Acoustic Mixing (LA-RAM)

10.26434/chemrxiv.11577561.v1 ◽

2020 ◽

Author(s):

Hatem M. Titi ◽

Jean-Louis Do ◽

Ashlee J. Howarth ◽

Karthik Nagapudi ◽

Tomislav Friscic

Keyword(s):

Metal Organic Frameworks ◽

Scale Up ◽

Three Dimensional ◽

Mixed Ligand ◽

Carboxylate Ligands ◽

Metal Organic ◽

Resonant Acoustic Mixing

We present a methodology for the rapid and readily scalable mechanosynthesis of diverse metal-organic frameworks (MOFs) in the absence of milling media, typically required for other types of mechanochemical syntheses. We demonstrate the use of liquid-assisted resonant acoustic mixing (LA-RAM) methodology for the synthesis of two- and three-dimensional MOFs based on Zn, Co(II) and Cu(II), including single- and mixed-ligand systems, imidazolate or carboxylate ligands. The LA-RAM approach also allowed the synthesis of the ZIF-L, a framework never previously obtained in a solventless environment, as well as its Co(II) analogue. Straightforward scale-up from milligrams to at least 25 grams is demonstrated using ZIF-L as the model.<br>

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Preparation of an Energetic-Energetic Cocrystal using Resonant Acoustic Mixing

Propellants Explosives Pyrotechnics ◽

10.1002/prep.201400092 ◽

2014 ◽

Vol 39 (5) ◽

pp. 637-640 ◽

Cited By ~ 35

Author(s):

Stephen R. Anderson ◽

David J. am Ende ◽

Jerry S. Salan ◽

Philip Samuels

Keyword(s):

Resonant Acoustic Mixing

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Verification of the mixing processes of the active pharmaceutical ingredient, excipient and lubricant in a pharmaceutical formulation using a resonant acoustic mixing technology

RSC Advances ◽

10.1039/c6ra16209f ◽

2016 ◽

Vol 6 (90) ◽

pp. 87049-87057 ◽

Cited By ~ 12

Author(s):

Ryoma Tanaka ◽

Naoyuki Takahashi ◽

Yasuaki Nakamura ◽

Yusuke Hattori ◽

Kazuhide Ashizawa ◽

...

Keyword(s):

Chemical Stability ◽

Pharmaceutical Formulations ◽

Active Pharmaceutical Ingredient ◽

Pharmaceutical Formulation ◽

Pharmaceutical Manufacturing ◽

High Quality ◽

Mixing Processes ◽

Resonant Acoustic Mixing

Mixing processes are important for making high-quality pharmaceutical formulations and are related to dissolution and chemical stability in pharmaceutical manufacturing.

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