Inactivation of the NF2 tumor suppressor protein merlin in DU145 prostate cancer cells

The Prostate ◽  
2008 ◽  
Vol 68 (9) ◽  
pp. 975-984 ◽  
Author(s):  
Akio Horiguchi ◽  
Rong Zheng ◽  
Ruoqian Shen ◽  
David M. Nanus
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Protein ◽  
Prostate Cancer Cells

Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein

2006 ◽  
Vol 72 (12) ◽  
pp. 1714-1723 ◽  
Author(s):  
Jocelyn C. Hsu ◽  
Anurupa Dev ◽  
Aimee Wing ◽  
Christine T. Brew ◽  
Leonard F. Bjeldanes ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Tumor Suppressor ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Tumor Suppressor Protein ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Cycle Arrest ◽  
P53 Tumor Suppressor Protein

scholarly journals The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells

Oncotarget ◽  
2014 ◽  
Vol 5 (21) ◽  
pp. 10678-10691 ◽  
Author(s):  
Lymor Ringer ◽  
Paul Sirajuddin ◽  
Lucas Tricoli ◽  
Sarah Waye ◽  
Muhammad Umer Choudhry ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Tumor Suppressor Protein ◽  
Prostate Cancer Cells ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Protein ◽  
Regulate Cell Death

scholarly journals Sodium Selenite Increases the Activity of the Tumor Suppressor Protein, PTEN, in DU-145 Prostate Cancer Cells

2009 ◽  
Vol 61 (3) ◽  
pp. 322-331 ◽  
Author(s):  
Margareta Berggren ◽  
Sivanandane Sittadjody ◽  
Zuohe Song ◽  
Jean-Louis Samira ◽  
Randy Burd ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Sodium Selenite ◽  
Tumor Suppressor Protein ◽  
Prostate Cancer Cells

The p202 Gene as a Tumor Suppressor in Prostate Cancer Cells

2003 ◽  
Author(s):  
Mien-Chie Hung
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Prostate Cancer Cells

scholarly journals Crosstalk between Prostate Cancer Cells and Tumor-Associated Fibroblasts Enhances the Malignancy by Inhibiting the Tumor Suppressor PLZF

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1083
Author(s):  
Kum Hee Noh ◽  
Ae Jin Jeong ◽  
Haeri Lee ◽  
Song-Hee Lee ◽  
Eunhee Yi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Cancer Metastasis ◽  
Tyrosine Phosphatase ◽  
Migration And Invasion ◽  
Metastatic Progression ◽  
Prostate Cancer Cells ◽  
Prostate Cancer Metastasis

Although prostate cancer is clinically manageable during the early stages of progression, metastatic progression severely compromises the prognosis and leads to mortality. Constitutive activation of STAT3 has been connected to prostate cancer malignancy, and abolishing the STAT3 activity may diminish tumor growth and metastasis. However, its suppressor genes and pathways have not been well established. In this study, we show that promyelocytic leukemia zinc finger (PLZF) has a putative tumor-suppressor function in prostate cancer by inhibiting phosphorylation of STAT3. Compared with a benign prostate, high-grade prostate cancer patient tissue was negatively correlated with PLZF expression. PLZF depletion accelerated proliferation and survival, migration, and invasion in human prostate cancer cells. Mechanistically, we demonstrated a novel role of PLZF as the transcriptional regulator of the tyrosine phosphatase SHP-1 that inhibits the oncogenic JAKs–STAT3 pathway. These results suggest that the collapse of PLZF expression by the CCL3 derived from fibroblasts accelerates the cell migration and invasion properties of prostate cancer cells. Our results suggest that increasing PLZF could be an attractive strategy for suppressing prostate cancer metastasis as well as for tumor growth.

MITOSTATIN, A NOVEL MITOCHONDRIAL PROTEIN, THAT ACTS AS A TUMOR SUPPRESSOR IN PROSTATE CANCER CELLS

2008 ◽  
Vol 179 (4S) ◽  
pp. 458-458
Author(s):  
Matteo Fassan ◽  
Domenico D'Arca ◽  
Juraj Letko ◽  
Andrea Vecchione ◽  
Andrea Morrione ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Mitochondrial Protein ◽  
Prostate Cancer Cells

Disulfiram and its novel derivative sensitize prostate cancer cells to the growth regulatory mechanisms of the cell by re-expressing the epigenetically repressed tumor suppressor-estrogen receptor β

2015 ◽  
Vol 55 (11) ◽  
pp. 1843-1857 ◽  
Author(s):  
Vikas Sharma ◽  
Vikas Verma ◽  
Nand Lal ◽  
Santosh K. Yadav ◽  
Saumya Sarkar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Estrogen Receptor Β ◽  
Regulatory Mechanisms ◽  
Prostate Cancer Cells
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