Expression of the gastrin-releasing peptide receptor, the prostate stem cell antigen and the prostate-specific membrane antigen in lymph node and bone metastases of prostate cancer

The Prostate ◽  
2009 ◽  
Vol 69 (10) ◽  
pp. 1101-1108 ◽  
Author(s):  
Hildo J.K. Ananias ◽  
Marius C. van den Heuvel ◽  
Wijnand Helfrich ◽  
Igle J. de Jong
Keyword(s):  
Prostate Cancer ◽  
Stem Cell ◽  
Lymph Node ◽  
Bone Metastases ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Stem Cell Antigen ◽  
Peptide Receptor ◽  
Cell Antigen ◽  
Gastrin Releasing Peptide ◽  
Specific Membrane

Simultaneous targeting of prostate stem cell antigen and prostate-specific membrane antigen improves the killing of prostate cancer cells using a novel modular T cell-retargeting system

The Prostate ◽  
2014 ◽  
Vol 74 (13) ◽  
pp. 1335-1346 ◽  
Author(s):  
Claudia Arndt ◽  
Anja Feldmann ◽  
Stefanie Koristka ◽  
Marc Cartellieri ◽  
Maria Dimmel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cell ◽  
T Cell ◽  
Cancer Cells ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Stem Cell Antigen ◽  
Prostate Cancer Cells ◽  
Cell Antigen ◽  
Specific Membrane

MONOCLONAL ANTIBODIES AGAINST PROSTATE STEM CELL ANTIGEN (PSCA) DETECT HIGH LEVELS OF PSCA EXPRESSION IN PROSTATE CANCER BONE METASTASES

1999 ◽  
pp. 125
Author(s):  
Zhennan Gu ◽  
Peter Shintaku ◽  
Joyce Yamashiro ◽  
Jonathan Said ◽  
Robert E. Reiter
Keyword(s):  
Prostate Cancer ◽  
Monoclonal Antibodies ◽  
Stem Cell ◽  
Bone Metastases ◽  
Prostate Stem Cell Antigen ◽  
Cell Antigen

Polarity of prostate specific membrane antigen, prostate stem cell antigen, and prostate specific antigen in prostate tissue and in a cultured epithelial cell line

The Prostate ◽  
2003 ◽  
Vol 55 (1) ◽  
pp. 9-19 ◽  
Author(s):  
Jason J. Christiansen ◽  
Sigrid A. Rajasekaran ◽  
Peggy Moy ◽  
Anthony Butch ◽  
Lee Goodglick ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epithelial Cell ◽  
Cell Line ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Epithelial Cell Line ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Stem Cell Antigen ◽  
Cell Antigen ◽  
Specific Membrane

scholarly journals Gastrin-Releasing Peptide Receptor in Low Grade Prostate Cancer: Can It Be a Better Predictor Than Prostate-Specific Membrane Antigen?

2021 ◽  
Vol 11 ◽  
Author(s):  
Pinuccia Faviana ◽  
Laura Boldrini ◽  
Paola Anna Erba ◽  
Iosè Di Stefano ◽  
Francesca Manassero ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Mechanisms ◽  
Tissue Expression ◽  
Low Grade ◽  
Prostate Specific Membrane Antigen ◽  
Peptide Receptor ◽  
Gastrin Releasing Peptide ◽  
Formalin Fixed Paraffin Embedded ◽  
Specific Membrane ◽  
Number Of Cells

The aim of the present study was to evaluate whether prostate cancer (PC) patients can be accurately classified on the bases of tissue expression of gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA). This retrospective study included 28 patients with PC. Formalin-fixed paraffin-embedded samples were used for diagnosis. Immunohistochemistry staining techniques were used to evaluate PSMA and GRPR expression (both number of cells expressed and % of area stained). To assess the independent associations among selected variables, a multi-dimensional scaling (MDS) analysis was used. It was found that the PSMA expression was inversely correlated with GRPR expression. Only the number of cells expressing GRPR was significantly related to the Gleason score. Both the percentage of area expressing GRPR and the number of cells expressing PSMA were close to reaching significance at the 0.05 level. MDS provided a map of the overall, independent association confirming that GRPR and PSMA represent inversely correlated measures of the same dimension. In conclusion, our data showed that GRPR expression should be evaluated in prostate biopsy specimens to improve our ability to detect PC with low grades at the earliest phases of development. Considering that GRPRs appear to be directly involved in the mechanisms of tumor proliferation, advancements in nuclear medicine radiotherapy can focus on this receptor to improve the therapeutic approach to PC. Further studies in our laboratory will investigate the molecular mechanisms of activation based on GRPR.

scholarly journals [89Zr]A2cDb Immuno-PET of Prostate Cancer in a Human Prostate Stem Cell Antigen Knock-in (hPSCA KI) Syngeneic Model

2019 ◽  
Vol 22 (2) ◽  
pp. 367-376 ◽  
Author(s):  
Kirstin A. Zettlitz ◽  
Wen-Ting K. Tsai ◽  
Scott M. Knowles ◽  
Felix B. Salazar ◽  
Naoko Kobayashi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cell ◽  
Human Prostate ◽  
Prostate Stem Cell Antigen ◽  
Cell Antigen ◽  
Syngeneic Model
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