Antifungal activity and mode of action of synthetic peptides derived from the tick OsDef2 defensin

2021 ◽  
Author(s):  
Kabuzi R. Mbuayama ◽  
Helena Taute ◽  
Adam A. Strӧmstedt ◽  
Megan J. Bester ◽  
Anabella R. M. Gaspar
Keyword(s):  
Antifungal Activity ◽  
Mode Of Action ◽  
Synthetic Peptides

Antifungal Activity, Mode of Action, Docking Prediction and Anti-biofilm Effects of (+)-β-pinene Enantiomers against Candida spp.

2019 ◽  
Vol 18 (29) ◽  
pp. 2481-2490 ◽  
Author(s):  
Ana Cláudia de Macêdo Andrade ◽  
Pedro Luiz Rosalen ◽  
Irlan Almeida Freires ◽  
Luciana Scotti ◽  
Marcus Tulius Scotti ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Mode Of Action ◽  
Candida Spp ◽  
Activity Mode

scholarly journals The newly synthesized thiazole derivatives as potential antifungal compounds against Candida albicans

2021 ◽  
Author(s):  
Anna Biernasiuk ◽  
Anna Berecka-Rycerz ◽  
Anna Gumieniczek ◽  
Maria Malm ◽  
Krzysztof Z. Łączkowski ◽  
...  
Keyword(s):  
Cell Wall ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Cell Membrane ◽  
Mode Of Action ◽  
Thiazole Derivatives ◽  
Fungal Cell ◽  
Erythrocyte Lysis ◽  
Low Cytotoxicity ◽  
High Antifungal Activity

Abstract Recently, the occurrence of candidiasis has increased dramatically, especially in immunocompromised patients. Additionally, their treatment is often ineffective due to the resistance of yeasts to antimycotics. Therefore, there is a need to search for new antifungals. A series of nine newly synthesized thiazole derivatives containing the cyclopropane system, showing promising activity against Candida spp., has been further investigated. We decided to verify their antifungal activity towards clinical Candida albicans isolated from the oral cavity of patients with hematological malignancies and investigate the mode of action on fungal cell, the effect of combination with the selected antimycotics, toxicity to erythrocytes, and lipophilicity. These studies were performed by the broth microdilution method, test with sorbitol and ergosterol, checkerboard technique, erythrocyte lysis assay, and reversed phase thin-layer chromatography, respectively. All derivatives showed very strong activity (similar and even higher than nystatin) against all C. albicans isolates with minimal inhibitory concentration (MIC) = 0.008–7.81 µg/mL Their mechanism of action may be related to action within the fungal cell wall structure and/or within the cell membrane. The interactions between the derivatives and the selected antimycotics (nystatin, chlorhexidine, and thymol) showed additive effect only in the case of combination some of them and thymol. The erythrocyte lysis assay confirmed the low cytotoxicity of these compounds as compared to nystatin. The high lipophilicity of the derivatives was related with their high antifungal activity. The present studies confirm that the studied thiazole derivatives containing the cyclopropane system appear to be a very promising group of compounds in treatment of infections caused by C. albicans. However, this requires further studies in vivo. Key points • The newly thiazoles showed high antifungal activity and some of them — additive effect in combination with thymol. • Their mode of action may be related with the influence on the structure of the fungal cell wall and/or the cell membrane. • The low cytotoxicity against erythrocytes and high lipophilicity of these derivatives are their additional good properties. Graphical abstract

Antifungal activity and mode of action of carvacrol againstCandida albicansstrains

2013 ◽  
Vol 25 (2) ◽  
pp. 138-142 ◽  
Author(s):  
Igara Oliveira Lima ◽  
Fillipe de Oliveira Pereira ◽  
Wylly Araújo de Oliveira ◽  
Edeltrudes de Oliveira Lima ◽  
Everardo Albuquerque Menezes ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Mode Of Action

scholarly journals New transition metal complexes with a pendent indole ring: insights into the antifungal activity and mode of action

RSC Advances ◽  
2019 ◽  
Vol 9 (27) ◽  
pp. 15151-15157 ◽  
Author(s):  
Ovas Ahmad Dar ◽  
Shabir Ahmad Lone ◽  
Manzoor Ahmad Malik ◽  
Mohmmad Younus Wani ◽  
Aijaz Ahmad ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Proton Pump ◽  
Mode Of Action ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Indole Ring ◽  
Significant Proton

Mixed ligand complexes containing a pendent indole showed significant proton pump ATPase targeted antifungal activity.

Antifungal activity of the cationic antimicrobial polymer-polyhexamethylene guanidine hydrochloride and its mode of action

2017 ◽  
Vol 121 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Hyemin Choi ◽  
Keuk-Jun Kim ◽  
Dong Gun Lee
Keyword(s):  
Antifungal Activity ◽  
Mode Of Action ◽  
Guanidine Hydrochloride ◽  
Polyhexamethylene Guanidine

Antifungal activity of synthetic peptides derived from Impatiens balsamina antimicrobial peptides Ib-AMP1 and Ib-AMP4

Peptides ◽  
2005 ◽  
Vol 26 (7) ◽  
pp. 1113-1119 ◽  
Author(s):  
Karin Thevissen ◽  
Isabelle E.J.A. François ◽  
Lolke Sijtsma ◽  
Aart van Amerongen ◽  
Wim M.M. Schaaper ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Antimicrobial Peptides ◽  
Synthetic Peptides ◽  
Impatiens Balsamina

Antifungal activity and mode of action of Galla rhois-derived phenolics against phytopathogenic fungi

2005 ◽  
Vol 81 (2) ◽  
pp. 105-112 ◽  
Author(s):  
Young-Joon Ahn ◽  
Hoi-Seon Lee ◽  
Hong-Sik Oh ◽  
Heung-Tae Kim ◽  
Yong-Hwan Lee
Keyword(s):  
Antifungal Activity ◽  
Mode Of Action ◽  
Phytopathogenic Fungi

scholarly journals A new methionine antagonist that has antifungal activity: Mode of action.

1994 ◽  
Vol 47 (8) ◽  
pp. 909-916 ◽  
Author(s):  
YUHKO AOKI ◽  
MASUMI KONDOH ◽  
MUTSUMI NAKAMURA ◽  
TOSHIHIKO FUJII ◽  
TOSHIKAZU YAMAZAKI ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Mode Of Action ◽  
Activity Mode

Antifungal activity of Coriandrum sativum essential oil, its mode of action against Candida species and potential synergism with amphotericin B

Phytomedicine ◽  
2011 ◽  
Vol 19 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Filomena Silva ◽  
Susana Ferreira ◽  
Andreia Duarte ◽  
Dina I. Mendonça ◽  
Fernanda C. Domingues
Keyword(s):  
Antifungal Activity ◽  
Essential Oil ◽  
Amphotericin B ◽  
Mode Of Action ◽  
Candida Species ◽  
Coriandrum Sativum

Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles

2019 ◽  
Vol 179 ◽  
pp. 779-790 ◽  
Author(s):  
Rebecca Elias ◽  
Raphael I. Benhamou ◽  
Qais Z. Jaber ◽  
Orly Dorot ◽  
Sivan Louzoun Zada ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Subcellular Distribution ◽  
Mode Of Action ◽  
Activity Mode
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