Hepatoprotective effect of ethanolic extract ofEclipta alba on experimental liver damage in rats and mice

1993 ◽  
Vol 7 (2) ◽  
pp. 154-158 ◽  
Author(s):  
B. Singh ◽  
A. K. Saxena ◽  
B. K. Chandan ◽  
S. G. Agarwal ◽  
M. S. Bhatia ◽  
...  
Keyword(s):  
Liver Damage ◽  
Ethanolic Extract ◽  
Hepatoprotective Effect ◽  
Rats And Mice ◽  
Experimental Liver ◽  
Experimental Liver Damage

Yang-Gan-Wan Protects Mice Against Experimental Liver Damage

2000 ◽  
Vol 28 (02) ◽  
pp. 155-162 ◽  
Author(s):  
Melissa Yang ◽  
Kevin Chen ◽  
Jean Chen Shih
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Alanine Aminotransferase ◽  
Allyl Alcohol ◽  
Herbal Remedy ◽  
Hepatoprotective Effect ◽  
Protective Effects ◽  
Chinese Herbal ◽  
Experimental Liver ◽  
Experimental Liver Damage

The hepatoprotective effect of Yang-Gan-Wan (YGW, Pro-Liver pill), a Chinese herbal remedy, was investigated in mice that were treated with allyl alcohol (AlOH), acetaminophen (AA) or carbon tetrachloride ( CCl 4). Mice were pretreated daily with 200 mg/kg YGW for 10, 14 and 18 days before treatment with 85 mg/kg AlOH, 475 mg/kg AA or 20 μl/kg CCl 4, respectively. YGW dramatically abolished the elevated activities of alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) and reduced the nectosis induced by AlOH. YGW also decreased the elevated activities of ALT and SDH and reduced the necrosis induced by AA and CCl 4. This study demonstrates that YGW has protective effects against liver damage induced by AlOH, AA, and CCl 4.

scholarly journals Influence of the Escherichia coli Nissle 1917 strain on complications of the chronic experimental liver damage

2008 ◽  
Vol 52 (No. 3) ◽  
pp. 121-129
Author(s):  
D. Kosakova ◽  
P. Scheer ◽  
J. Lata ◽  
J. Doubek
Keyword(s):  
Escherichia Coli ◽  
Lymph Nodes ◽  
Liver Damage ◽  
Weight Ratio ◽  
Coliform Bacteria ◽  
Control Group ◽  
Significant Difference ◽  
And Control ◽  
Experimental Liver ◽  
Experimental Liver Damage

The aim of the study was evaluate the influence of the probiotic <i>Escherichia coli</i> Nissle 1917 strain (Mutaflor&reg; suspension, Ardeypharm GmbH, Herdecke, Germany) on bacterial translocation in cases of liver damage, damage to the intestinal mucosa, potential portal hypertension associated with possible development of oesophageal varices and on the bacterial population of the intestine during chronic experimental liver damage in the laboratory rat. Rats with liver damage induced by thioacetamide were divided into an experimental and control group. Experimental and control animals were applied Mutaflor and saline, respectively. Samples of blood, liver, lymph nodes and caecum for microbiological examination, of liver, duodenum and oesophagus for histological examination and of spleen for weight evaluation were collected. There were no significant differences between both groups of animals in the qualitative proportion of <i>Staphylococcus</i> spp., <i>Enterococcus</i> spp. and <i>Proteus</i> spp. cultured from the lymph nodes, blood and liver. The quantitative culture results on <i>Enterococcus</i> spp. in the caecum, liver and lymph nodes showed no significant differences between both groups. There was a significant difference between the experimental and control group in the counts of coliform bacteria. No significant differences between both groups were found in the overall damage score of the liver, duodenum and oesophagus. There were no differences in the spleen to body weight ratio of both groups. The application of Mutaflor&reg; suspension for eight days had no recognisable effect diminishing the selected complications of chronic liver damage caused by the administration of TAA to laboratory rats.

Changes in activation of aspartate aminotransferase by pyridoxal 5'-phosphate after experimental liver damage in rabbits

1982 ◽  
Vol 122 (3) ◽  
pp. 395-401 ◽  
Author(s):  
A. de Waal ◽  
S. le Roux ◽  
G.M. Potgieter ◽  
H.C. Barnard ◽  
E.M.S.P. Schoombie
Keyword(s):  
Liver Damage ◽  
Aspartate Aminotransferase ◽  
Experimental Liver ◽  
Experimental Liver Damage

scholarly journals EFFECT OF ETHANOLIC EXTRACT OF TINOSPORA CRISPA L FROM INDONESIA IN ALLOXAN INDUCED LIVER DAMAGE

2017 ◽  
Vol 9 (8) ◽  
pp. 65
Author(s):  
Emsutrisna . ◽  
Fahrizal Aria Sahadewa ◽  
Ikbar Ardiansyah
Keyword(s):  
Body Weight ◽  
Liver Damage ◽  
Histopathological Examination ◽  
Ethanolic Extract ◽  
Hepatoprotective Effect ◽  
Male Rats ◽  
Histopathologic Examination ◽  
Wistar Strain ◽  
Alloxan Monohydrate ◽  
Group 1

Objective: The objective of this study was to evaluate the hepatoprotective effect of Tinospora crispa L. (Bratawali).Methods: Twenty four male rats wistar strain were divided into four groups. The serum alanine amino transferase (ALT) and aspartate aminotransferase (AST) of rats were measured (day 0). Rats then were injected by alloxan monohydrate at doses of 120 mg/200 bw (g) intraperitoneally. Four days later, the serum ALT and AST of rats were measured (second measurement/day 4) and then were treated by extract appropriate their groups. Group 1 was treated by 2 ml of distilled water orally; group 2,3 and 4 were treated by 70% ethanolic extract of T. crispa L. (EETC) at dose of 100; 200 and 400 mg/200 bw (g)/day respectively orally. After 10 d treatment, serum ALT and AST were measured (third measurement/day 14). At the end of this treatment, all rats were killed for histopathologic examination of their liver. The histopathologic examination was performed to assess the number of pyknotic nuclei, karyorrhexis nuclei and karyolysis nuclei.Results: The result of this study showed that the ethanolic extract of T. crispa L at dose of 100 and 200 mg/200gbw can reduce blood ALT and AST significantly (P<0.05). From the histopathological examination, it was found that the number of pyknotic nuclei, karyorrhexis nuclei and karyolysis nuclei of EETC at doses of 100 and 200 mg/200 body weight (g) lower than negative control.Conclusion: The present study shows that the 70% EETC at dose of 100 and 200 mg/200 body weight (g) has hepatoprotective effect against alloxan induced liver damage.  

Behavior of Serum Glycoprotein and Haptoglobin Levels in Experimental Liver Damage in Rats

Pharmacology ◽  
1966 ◽  
Vol 14 (5) ◽  
pp. 485-492
Author(s):  
I. Piukovich ◽  
L. Varga ◽  
M. Gábor ◽  
M. Tényi ◽  
E. Horváth ◽  
...  
Keyword(s):  
Liver Damage ◽  
Serum Glycoprotein ◽  
Experimental Liver ◽  
Experimental Liver Damage
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