Hypolipidemic activity and mechanisms of the total phenylpropanoid glycosides from Ligustrum robustum (Roxb.) Blume by AMPK-SREBP-1c pathway in hamsters fed a high-fat diet

2018 ◽  
Vol 32 (4) ◽  
pp. 715-722 ◽  
Author(s):  
Runmei Yang ◽  
Xinxin Chu ◽  
Le Sun ◽  
Zhuoying Kang ◽  
Min Ji ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Hypolipidemic Activity ◽  
High Fat ◽  
Phenylpropanoid Glycosides

scholarly journals Hypolipidemic activity of Moringa oleifera Lam., Moringaceae, on high fat diet induced hyperlipidemia in albino rats

2010 ◽  
Vol 20 (6) ◽  
pp. 969-973 ◽  
Author(s):  
Pankaj G. Jain ◽  
Savita D. Patil ◽  
Nitin G. Haswani ◽  
Manoj V. Girase ◽  
Sanjay J. Surana
Keyword(s):  
High Fat Diet ◽  
Moringa Oleifera ◽  
Hypolipidemic Activity ◽  
Albino Rats ◽  
High Fat ◽  
Moringa Oleifera Lam

scholarly journals EVALUATION HYPOLIPIDEMIC ACTIVITY OF AROGYAVARDHINI AND ZPTER TABLET IN CHOLESTEROL-RICH HIGH FAT DIET (HFD) INDUCED HYPERLIPIDEMIA IN WISTAR RATS

2019 ◽  
pp. 1-5
Author(s):  
Dinesh D. Ghadigaonkar ◽  
MUKESH B. CHAWDA ◽  
KAPIL S. THAKUR ◽  
PAWAN K. KUSHWAH
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
Standard Treatment ◽  
Research Work ◽  
Hypolipidemic Activity ◽  
Control Group ◽  
High Fat ◽  
Post Hoc ◽  
Profile Estimation ◽  
Herbal Formulations

Objective: The present research work aims to evaluate the hypolipidemic activity of arogyavardhini and zpter tablet in high fat diet (HFD) induced hyperlipidemia in wistar rats. Methods: Wistar rats were divided in 5 groups. The normal control group received standard pellet diet. The HFD group received HFD rich in cholesterol. The HFD+Arogyavardhini group received HFD rich in cholesterol along with Arogyavardhini treatment. The HFD+zpter group received HFD rich in cholesterol along with zpter treatment. The standard Control group received HFD rich in cholesterol and treatment with Atorvastatin. Serum Lipid profile estimation and histopathological estimations done at end treatment. Group means were compared with Analysis of Variance (ANOVA) followed by Tukey‘s post-hoc analysis (P<0.05). Result: HFD group shows significant (P<0.05) increase in total cholesterol (TC) levels (207.15 mg/dl) and triglyceride (TG) levels (223.83 mg/dl) when compared with standard pellet fed rats (TC=151.05 mg/dl and TG=164.67 mg/dl). Treatment with Arogyavardhini significantly (P<0.05) reduces the increased levels of TC (160.123 mg/dl) and TG (189.5 mg/dl) in hyperlipedimic rats. Treatment with Zpter significantly (P<0.05) reduces the increased levels of TC (163.89 mg/dl) and TG (193.167 mg/dl) in hyperlipedimic rats, which is comparable to standard treatment atorvastatin (TC= 155.81 mg/dl, TG=180.33 mg/dl). Conclusion: The observations in this study suggest that, herbal formulations arogyavardhini and zpter have the potential to overcome hyperlipidemia.

scholarly journals GCMS Analysis and Hypolipidemic Activity of Dioscorea bulbifera (L) in High Fat Diet Induced Hypercholesterolemic Rats

2021 ◽  
Vol 15 (1) ◽  
pp. 23-29
Author(s):  
Subasini Uthirapath ◽  
Javed Ahamad ◽  
Omji Porwal ◽  
Muath S. Mohammed A ◽  
Esra T. Anwer
Keyword(s):  
High Fat Diet ◽  
Hypolipidemic Activity ◽  
High Fat ◽  
Dioscorea Bulbifera

scholarly journals Hypolipidemic activity of Piper betel in high fat diet induced hyperlipidemic rat

2014 ◽  
Vol 3 (2) ◽  
pp. 131-135 ◽  
Author(s):  
Thirunavukkarasu Thirumalai ◽  
Narayanaswamy Tamilselvan ◽  
Ernest David
Keyword(s):  
High Fat Diet ◽  
Hypolipidemic Activity ◽  
High Fat

Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones

2019 ◽  
Vol 89 (1-2) ◽  
pp. 45-54
Author(s):  
Akemi Suzuki ◽  
André Manoel Correia-Santos ◽  
Gabriela Câmara Vicente ◽  
Luiz Guillermo Coca Velarde ◽  
Gilson Teles Boaventura
Keyword(s):  
Thyroid Hormones ◽  
High Fat Diet ◽  
Female Offspring ◽  
Flaxseed Oil ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Flour ◽  
Maternal Consumption

Abstract. Objective: This study aimed to evaluate the effect of maternal consumption of flaxseed flour and oil on serum concentrations of glucose, insulin, and thyroid hormones of the adult female offspring of diabetic rats. Methods: Wistar rats were induced to diabetes by a high-fat diet (60%) and streptozotocin (35 mg/kg). Rats were mated and once pregnancy was confirmed, were divided into the following groups: Control Group (CG): casein-based diet; High-fat Group (HG): high-fat diet (49%); High-fat Flaxseed Group (HFG): high-fat diet supplemented with 25% flaxseed flour; High-fat Flaxseed Oil group (HOG): high-fat diet, where soya oil was replaced with flaxseed oil. After weaning, female pups (n = 6) from each group were separated, received a commercial rat diet and were sacrificed after 180 days. Serum insulin concentrations were determined by ELISA, the levels of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined by chemiluminescence. Results: There was a significant reduction in body weight at weaning in HG (−31%), HFG (−33%) and HOG (44%) compared to CG (p = 0.002), which became similar by the end of 180 days. Blood glucose levels were reduced in HFG (−10%, p = 0.044) when compared to CG, and there was no significant difference between groups in relation to insulin, T3, T4, and TSH after 180 days. Conclusions: Maternal severe hyperglycemia during pregnancy and lactation resulted in a microsomal offspring. Maternal consumption of flaxseed reduces blood glucose levels in adult offspring without significant effects on insulin levels and thyroid hormones.

Topical Application of Capsaicin Reduces Visceral Adipose Fat by Affecting Adipokine Levels in High-Fat Diet-Induced Obese Mice

Obesity ◽  
2012 ◽  
Author(s):  
Gong-Rak Lee ◽  
Mi Kyung Shin ◽  
Dong-Joon Yoon ◽  
Ah-Ram Kim ◽  
Rina Yu ◽  
...  
Keyword(s):  
Topical Application ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Visceral Adipose
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