scholarly journals GCMS Analysis and Hypolipidemic Activity of Dioscorea bulbifera (L) in High Fat Diet Induced Hypercholesterolemic Rats

2021 ◽  
Vol 15 (1) ◽  
pp. 23-29
Author(s):  
Subasini Uthirapath ◽  
Javed Ahamad ◽  
Omji Porwal ◽  
Muath S. Mohammed A ◽  
Esra T. Anwer
Keyword(s):  
High Fat Diet ◽  
Hypolipidemic Activity ◽  
High Fat ◽  
Dioscorea Bulbifera

scholarly journals Hypolipidemic activity of Moringa oleifera Lam., Moringaceae, on high fat diet induced hyperlipidemia in albino rats

2010 ◽  
Vol 20 (6) ◽  
pp. 969-973 ◽  
Author(s):  
Pankaj G. Jain ◽  
Savita D. Patil ◽  
Nitin G. Haswani ◽  
Manoj V. Girase ◽  
Sanjay J. Surana
Keyword(s):  
High Fat Diet ◽  
Moringa Oleifera ◽  
Hypolipidemic Activity ◽  
Albino Rats ◽  
High Fat ◽  
Moringa Oleifera Lam

Hypolipidemic activity and mechanisms of the total phenylpropanoid glycosides from Ligustrum robustum (Roxb.) Blume by AMPK-SREBP-1c pathway in hamsters fed a high-fat diet

2018 ◽  
Vol 32 (4) ◽  
pp. 715-722 ◽  
Author(s):  
Runmei Yang ◽  
Xinxin Chu ◽  
Le Sun ◽  
Zhuoying Kang ◽  
Min Ji ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Hypolipidemic Activity ◽  
High Fat ◽  
Phenylpropanoid Glycosides

scholarly journals EVALUATION HYPOLIPIDEMIC ACTIVITY OF AROGYAVARDHINI AND ZPTER TABLET IN CHOLESTEROL-RICH HIGH FAT DIET (HFD) INDUCED HYPERLIPIDEMIA IN WISTAR RATS

2019 ◽  
pp. 1-5
Author(s):  
Dinesh D. Ghadigaonkar ◽  
MUKESH B. CHAWDA ◽  
KAPIL S. THAKUR ◽  
PAWAN K. KUSHWAH
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
Standard Treatment ◽  
Research Work ◽  
Hypolipidemic Activity ◽  
Control Group ◽  
High Fat ◽  
Post Hoc ◽  
Profile Estimation ◽  
Herbal Formulations

Objective: The present research work aims to evaluate the hypolipidemic activity of arogyavardhini and zpter tablet in high fat diet (HFD) induced hyperlipidemia in wistar rats. Methods: Wistar rats were divided in 5 groups. The normal control group received standard pellet diet. The HFD group received HFD rich in cholesterol. The HFD+Arogyavardhini group received HFD rich in cholesterol along with Arogyavardhini treatment. The HFD+zpter group received HFD rich in cholesterol along with zpter treatment. The standard Control group received HFD rich in cholesterol and treatment with Atorvastatin. Serum Lipid profile estimation and histopathological estimations done at end treatment. Group means were compared with Analysis of Variance (ANOVA) followed by Tukey‘s post-hoc analysis (P<0.05). Result: HFD group shows significant (P<0.05) increase in total cholesterol (TC) levels (207.15 mg/dl) and triglyceride (TG) levels (223.83 mg/dl) when compared with standard pellet fed rats (TC=151.05 mg/dl and TG=164.67 mg/dl). Treatment with Arogyavardhini significantly (P<0.05) reduces the increased levels of TC (160.123 mg/dl) and TG (189.5 mg/dl) in hyperlipedimic rats. Treatment with Zpter significantly (P<0.05) reduces the increased levels of TC (163.89 mg/dl) and TG (193.167 mg/dl) in hyperlipedimic rats, which is comparable to standard treatment atorvastatin (TC= 155.81 mg/dl, TG=180.33 mg/dl). Conclusion: The observations in this study suggest that, herbal formulations arogyavardhini and zpter have the potential to overcome hyperlipidemia.

scholarly journals Hypolipidemic activity of Piper betel in high fat diet induced hyperlipidemic rat

2014 ◽  
Vol 3 (2) ◽  
pp. 131-135 ◽  
Author(s):  
Thirunavukkarasu Thirumalai ◽  
Narayanaswamy Tamilselvan ◽  
Ernest David
Keyword(s):  
High Fat Diet ◽  
Hypolipidemic Activity ◽  
High Fat

scholarly journals Evaluation of Antihyperlipidaemic Activities of Hydromethanolic Extracts of Dioscorea bulbifera

2020 ◽  
pp. 16-25
Author(s):  
Bruno Chukwuemeka Chinko ◽  
Datonye Victor Dapper ◽  
Olaghaguo Maestephen Adienbo
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
Density Lipoprotein ◽  
Serum Glucose ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Chemical Induction ◽  
High Fat ◽  
Rat Models ◽  
Dioscorea Bulbifera

Introduction: Hyperlipidemia is a leading cause of cardiovascular diseases (CHDs) with treatment ranging from dietary management and the use of antihyperlipidaemic drugs. The desire for anti-hyperlipidaemic drugs with less side effects has led to the screening of medical with anti-hyperlipidaemic properties. Aim: The present study is aimed at evaluating the effects of hydromethanolic extracts of Dioscorea bulbifera on high fat diet, tyloxapol and dexamethasone induced hyperlipidaemia using Wistar rat models. Methodology: Fifty five (55) adult male Wistar rats weighing 180-250 g were used for the study. Natural induction of hyperlipidaemia was done using a formulated High fat diet made from commercial rat chow and rendered cow fat while chemical induction of hyperlipidaemia was done using tyloxapol (200 mg/kg) and dexamethasone (20 mg/kg). The Wistar rats where divided into eleven (11) groups comprising four (5) control groups and seven (6) experimental groups. The extracts were used to treat the hyperlipidaemic rats at 200 mg/kg and 400 mg/kg while Simvastatin was used as a standard. Blood samples of the animals were analyzed for Total cholesterol (TC), Triglycerides (TG), High density lipoproteins (HDL), Low density lipoproteins (LDL), Very low density lipoprotein (VLDL) and Serum glucose were determined by standard enzymatic methods. Results: The results indicate that the hyperlipidaemic rats treated with extracts of Dioscorea bulbifera had significantly reduced TC, TG, LDL, VLDL and serum glucose compared with the control (untreated hyperlipidaemic rats) (P<0.05). In the same way, the HDL was found to be significantly higher among the treated hyperlipidaemic rats compared with the untreated controls. Conclusion: The present study shows that hydromethanolic extracts of Dioscorea bulbifera has a possible antihyperlipidaemic potentials as demonstrated by its ability to significantly improve lipid profile and lower serum glucose levels in hyperlipidaemic rat models.

Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones

2019 ◽  
Vol 89 (1-2) ◽  
pp. 45-54
Author(s):  
Akemi Suzuki ◽  
André Manoel Correia-Santos ◽  
Gabriela Câmara Vicente ◽  
Luiz Guillermo Coca Velarde ◽  
Gilson Teles Boaventura
Keyword(s):  
Thyroid Hormones ◽  
High Fat Diet ◽  
Female Offspring ◽  
Flaxseed Oil ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Flour ◽  
Maternal Consumption

Abstract. Objective: This study aimed to evaluate the effect of maternal consumption of flaxseed flour and oil on serum concentrations of glucose, insulin, and thyroid hormones of the adult female offspring of diabetic rats. Methods: Wistar rats were induced to diabetes by a high-fat diet (60%) and streptozotocin (35 mg/kg). Rats were mated and once pregnancy was confirmed, were divided into the following groups: Control Group (CG): casein-based diet; High-fat Group (HG): high-fat diet (49%); High-fat Flaxseed Group (HFG): high-fat diet supplemented with 25% flaxseed flour; High-fat Flaxseed Oil group (HOG): high-fat diet, where soya oil was replaced with flaxseed oil. After weaning, female pups (n = 6) from each group were separated, received a commercial rat diet and were sacrificed after 180 days. Serum insulin concentrations were determined by ELISA, the levels of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined by chemiluminescence. Results: There was a significant reduction in body weight at weaning in HG (−31%), HFG (−33%) and HOG (44%) compared to CG (p = 0.002), which became similar by the end of 180 days. Blood glucose levels were reduced in HFG (−10%, p = 0.044) when compared to CG, and there was no significant difference between groups in relation to insulin, T3, T4, and TSH after 180 days. Conclusions: Maternal severe hyperglycemia during pregnancy and lactation resulted in a microsomal offspring. Maternal consumption of flaxseed reduces blood glucose levels in adult offspring without significant effects on insulin levels and thyroid hormones.

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