Moracin D induces apoptosis in prostate cancer cells via activation of PPAR gamma/ PKC delta and inhibition of PKC alpha

2021 ◽  
Author(s):  
Jae Seok Yoon ◽  
Hyo‐Jung Lee ◽  
Deok Yong Sim ◽  
Eunji Im ◽  
Ji Eon Park ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Ppar Gamma ◽  
Prostate Cancer Cells ◽  
Pkc Delta ◽  
Pkc Alpha

Gamma Tocopherol Upregulates the Expression of 15-S-HETE and Induces Growth Arrest Through a PPAR Gamma-Dependent Mechanism in PC-3 Human Prostate Cancer Cells

2009 ◽  
Vol 61 (5) ◽  
pp. 649-662 ◽  
Author(s):  
Sharon E. Campbell ◽  
Phillip R. Musich ◽  
Sarah G. Whaley ◽  
Julie B. Stimmel ◽  
Lisa M. Leesnitzer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Growth Arrest ◽  
Ppar Gamma ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Gamma Tocopherol ◽  
Dependent Mechanism

scholarly journals The PPAR Gamma Agonist Troglitazone Regulates Erk 1/2 Phosphorylation via a PPARγ-Independent, MEK-Dependent Pathway in Human Prostate Cancer Cells

PPAR Research ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Adrienne Bolden ◽  
Lynikka Bernard ◽  
Danielle Jones ◽  
Tunde Akinyeke ◽  
LaMonica V. Stewart
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Control Cell ◽  
Ppar Gamma ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Antitumor Effects ◽  
Erk Phosphorylation

Thiazolidinediones (TZDs) dramatically reduce the growth of human prostate cancer cellsin vitroandin vivo. To determine whether the antitumor effects of TZDs were due in part to changes in the MEK/Erk signaling pathway, we examined the regulation of Erk phosphorylation by the TZD troglitazone within the PC-3 and C4-2 human prostate cancer cell lines. Western blot analysis revealed troglitazone-induced phosphorylation of Erk in both PC-3 and C4-2 cells. Troglitazone-induced increases in Erk phosphorylation were suppressed by the MEK inhibitor U0126 but not by the PPARγantagonist GW9662. Pretreatment with U0126 did not alter the ability of troglitazone to regulate expression of two proteins that control cell cycle, p21, and c-Myc. Troglitazone was also still effective at reducing PC-3 proliferation in the presence of U0126. Therefore, our data suggest that troglitazone-induced Erk phosphorylation does not significantly contribute to the antiproliferative effect of troglitazone.

279: Inhibition of Cyclooxygenase-2 Pathway Overcomes the Heat-Resistance in Prostate Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 93-93
Author(s):  
Makoto Sumitomo ◽  
Kenji Kuroda ◽  
Takako Asano ◽  
Akio Horiguchi ◽  
Keiichi Ito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Heat Resistance ◽  
Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Prostate Cancer Cells

574: Cellular Interaction Between Prostate Cancer and Bone Stroma: Effects of Radiation on the Growth and Colonization of Human Prostate Cancer Cells in Bone

2005 ◽  
Vol 173 (4S) ◽  
pp. 157-157
Author(s):  
Tohru Miyagi ◽  
Cynthia S. Anderson ◽  
Valerie A. Odero-Marah ◽  
Peter Johnstone ◽  
Leland W.K. Chung
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Cellular Interaction ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Effects Of Radiation

430: Modulation of Heat-Shock Protein 90 (HSP90) Client Protein Expression in Prostate Cancer Cells by a Novel Novobiocin Analog

2006 ◽  
Vol 175 (4S) ◽  
pp. 140-140
Author(s):  
Manlio A. Goetzl ◽  
Brian S. Blagg ◽  
Benjamin Cronk ◽  
Len Neckers ◽  
Jeffrey M. Holzbeierlein
Keyword(s):  
Prostate Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Protein Expression ◽  
Cancer Cells ◽  
Heat Shock Protein 90 ◽  
Client Protein ◽  
Prostate Cancer Cells ◽  
Hsp90 Client Protein

609: Effects of Sirna and Phytoestrogen Treatments on the Expression of Genes Regulated through the Androgen Receptor of Lncap Prostate Cancer Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 162-162
Author(s):  
Paul Thelen ◽  
Michal Grzmil ◽  
Iris E. Eder ◽  
Barbara Spengler ◽  
Peter Burfeind ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Expression Of Genes

Pharmacoproteomic and toxicoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells using iTRAQ with 2D LC and tandem mass spectrometry

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Halabalaki ◽  
IT Roumeliotis ◽  
E Giannopoulou ◽  
X Alexi ◽  
L Meijer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Cancer Cells ◽  
Natural Product ◽  
Tandem Mass ◽  
Prostate Cancer Cells

Antimetastatic activity of halichondramide for human prostate cancer cells via modulation of PRL-3 signaling

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
Y Shin ◽  
GD Kim ◽  
JE Jeon ◽  
J Shin ◽  
SK Lee
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Antimetastatic Activity
Sign in / Sign up

Export Citation Format

Share Document