On-line monitoring of the dynamics of trihalomethane concentrations in a warm public swimming pool using an unsupervised membrane inlet mass spectrometry system with off-site real-time surveillance

2009 ◽  
Vol 24 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Gert H. Kristensen ◽  
Morten M. Klausen ◽  
Vagn A. Hansen ◽  
Frants R. Lauritsen

2007 ◽  
Vol 106 (4) ◽  
pp. 665-674 ◽  
Author(s):  
Cyrill Hornuss ◽  
Siegfried Praun ◽  
Johannes Villinger ◽  
Albert Dornauer ◽  
Patrick Moehnle ◽  
...  

Background The physicochemical properties of propofol could allow diffusion across the alveolocapillary membrane and a measurable degree of pulmonary propofol elimination. The authors tested this hypothesis and showed that propofol can be quantified in expiratory air and that propofol breath concentrations reflect blood concentrations. This could allow real-time monitoring of relative changes in the propofol concentration in arterial blood during total intravenous anesthesia. Methods The authors measured gas-phase propofol using a mass spectrometry system based on ion-molecule reactions coupled with quadrupole mass spectrometry which provides a highly sensitive method for on-line and off-line measurements of organic and inorganic compounds in gases. In a first sequence of experiments, the authors sampled blood from neurosurgery patients undergoing total intravenous anesthesia and performed propofol headspace determination above the blood sample using an auto-sampler connected to the mass spectrometry system. In a second set of experiments, the mass spectrometry system was connected directly to neurosurgery patients undergoing target-controlled infusion via a T piece inserted between the endotracheal tube and the Y connector of the anesthesia machine, and end-expiratory propofol concentrations were measured on-line. Results A close correlation between propofol whole blood concentration and propofol headspace was found (range of Pearson r, 0.846-0.957; P < 0.01; n = 6). End-expiratory propofol signals mirrored whole blood values with close intraindividual correlations between both parameters (range of Pearson r, 0.784-0.985; n = 11). Conclusion Ion-molecule reaction mass spectrometry may allow the continuous and noninvasive monitoring of expiratory propofol levels in patients undergoing general anesthesia.



2002 ◽  
Vol 74 (1) ◽  
pp. 300-304 ◽  
Author(s):  
Colin S. Creaser ◽  
David Gómez Lamarca ◽  
Jeffrey Brum ◽  
Christopher Werner ◽  
Anthony P. New ◽  
...  




2017 ◽  
Vol 31 (12) ◽  
pp. 1073-1076
Author(s):  
Feng Zhou ◽  
Shu Liu ◽  
Junpeng Xing ◽  
Zhiqiang Liu ◽  
Fengrui Song


2008 ◽  
Vol 22 (19) ◽  
pp. 2993-2998 ◽  
Author(s):  
Liang Zhu ◽  
Gerardo Gamez ◽  
Huan Wen Chen ◽  
Hao Xi Huang ◽  
Konstantin Chingin ◽  
...  




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