Detection and structural characterization of the metabolites of dihydroresveratrol in rats by liquid chromatography coupled to high resolution tandem mass spectrometry

2020 ◽  
Author(s):  
Qiang‐Guo Ji ◽  
Ming‐Hua Ma ◽  
Xue‐Mei Hu ◽  
Yi‐Jun Zhang ◽  
Xiao‐Hong Xu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
High Resolution ◽  
Tandem Mass Spectrometry ◽  
Structural Characterization ◽  
Tandem Mass

Identification and structural characterization of four novel degradation products and a process impurity of isavuconazonium sulfate for injection formulation bulk by LC-ESI-QTOF-MS/MS

2019 ◽  
Vol 26 (2) ◽  
pp. 144-152
Author(s):  
Venkata Rama Prabhakara Sastry Regella ◽  
Venkatesan Chidambaram Subramanian ◽  
Sarveswara Sastry Bhetanabhotla
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Structural Characterization ◽  
Alkaline Hydrolysis ◽  
Degradation Products ◽  
Water Soluble ◽  
Tandem Mass ◽  
Light Conditions

Isavuconazonium sulfate is a highly water-soluble pro-drug of active triazole isavuconazole. The degradation profile of isavuconazonium sulfate for injection formulation bulk under acid hydrolysis, alkaline hydrolysis, oxidation, heat, and light conditions was studied using LC-PDA/MS technique. Four degradation products (DP1 to DP4) and one process impurity (PI1) were identified in isavuconazonium sulfate formulation bulk and characterized the identified impurities by liquid chromatography-electron spray ionization-quadruple-time of flight tandem mass spectrometry. Isavuconazole (DP1) was found to be one of the major degradation products of isavuconazonium sulfate.

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