scholarly journals Voluntary exercise influences metastatic organotropism in a murine colorectal cancer model

2021 ◽  
Author(s):  
Liza A. Wijler ◽  
Danielle A.E. Raats ◽  
Andre Verheem ◽  
Anna M. Otter ◽  
Helene Rundqvist ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Voluntary Exercise ◽  
Cancer Model

Abstract 3480: Potential impact of voluntary exercise on patterns of metastasis in a colorectal cancer model

2020 ◽  
Author(s):  
Liza A. Wijler ◽  
Daniëlle A. Raats ◽  
Miriam van Dijk ◽  
Anne M. May ◽  
Onno Kranenburg
Keyword(s):  
Colorectal Cancer ◽  
Voluntary Exercise ◽  
Cancer Model ◽  
Potential Impact

Sulfonamide-Functionalized Polymeric Nanoparticles For Enhanced In Vivo Colorectal Cancer Therapy

2021 ◽  
Vol 18 ◽  
Author(s):  
Pedro Pires Goulart Guimarães ◽  
Celso Tarso Rodrigues Viana ◽  
Luciana Pereira ◽  
Savio Morato Lacerda Gontijo ◽  
Paula Peixoto Campos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Polymeric Nanoparticles ◽  
Acquired Resistance ◽  
Lung Mass ◽  
Cancer Model ◽  
Liver Mass ◽  
Therapeutic Delivery ◽  
Promising Strategy ◽  
Common Cancer

Background: Colorectal cancer (CRC) is the third most common cancer in the world. 5-Fluorouracil (5-FU) is a conventional and most effective drug used in the clinic for the treatment of CRC. However, the clinical use of 5-FU is limited due to the acquired resistance and systemic toxicity, such as hepatotoxicity and gastrointesti-nal toxicity. Objective: Recent advances in nanomedicine are being exploited to develop nanoparticle platforms to overcome resistance and therapeutic delivery of active molecules. Here, we develop 5-FU loaded sulfadiazine-poly(lactide-co-glycolide) nanoparticles (SUL-PLGA NPs) to be applied in the colorectal cancer model. Methods: We assessed the in vivo efficacy of the SUL-PLGA NPs to enhance the antitumor effect of 5-FU. Results: In vivo treatment with 5-FU-SUL-PLGA NPs significantly reduced tumor growth in a colon cancer xen-ograft model compared to free 5-FU and 5-FU loaded non-targeted NPs. Treatment with 5-FU-SUL-PLGA NPs also increased blood vessel diameters within tumors, which could act in conjunction to enhance antitumor effi-cacy. In addition, 5-FU-SUL-PLGA NPs significantly reduced liver mass and lung mass, which are the most common metastasis sites of CRC, and decreased liver hepatotoxicity compared to free 5-FU drug and 5-FU loaded non-targeted NPs. Conclusion: Our findings suggest that the use of 5-FU-SUL-PLGA NPs is a promising strategy to enhance 5-FU efficacy against CRC.

scholarly journals Chemopreventive properties of curcumin analogues, hexagamavunone-0 and gamavutone-0, in rat colorectal cancer model

2017 ◽  
Vol 16 (9) ◽  
pp. 2141
Author(s):  
Risfah Yulianty ◽  
Lukman Hakim ◽  
Sardjiman Sardjiman ◽  
Gemini Alam ◽  
Sitarina Widyarini
Keyword(s):  
Colorectal Cancer ◽  
Cancer Model ◽  
Curcumin Analogues

scholarly journals PD-L1 pathway activation as an escape mechanism of resistance to MEK inhibitor treatment in a human colorectal cancer model

2016 ◽  
Vol 27 ◽  
pp. vi5
Author(s):  
S. Napolitano ◽  
B. Valentina ◽  
E. Martinelli ◽  
V. Sforza ◽  
P.P. Vitiello ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mek Inhibitor ◽  
Cancer Model ◽  
Human Colorectal Cancer ◽  
Escape Mechanism ◽  
Mechanism Of Resistance ◽  
Pathway Activation ◽  
Inhibitor Treatment

Preclinical three-dimensional colorectal cancer model: The next generation of in vitro drug efficacy evaluation

2018 ◽  
Vol 234 (1) ◽  
pp. 181-191 ◽  
Author(s):  
Francesca Sensi ◽  
Edoardo D’Angelo ◽  
Sara D’Aronco ◽  
Roberto Molinaro ◽  
Marco Agostini
Keyword(s):  
Colorectal Cancer ◽  
Three Dimensional ◽  
Drug Efficacy ◽  
Next Generation ◽  
Cancer Model ◽  
Efficacy Evaluation

Su1205 GLYPHOSATE EXPOSURE ALTERS THE HOST MICROBIOME AND LEADS TO WORSENED DSS-INDUCED COLITIS AND ENHANCED TUMORIGENESIS IN A COLORECTAL CANCER MODEL

2020 ◽  
Vol 158 (6) ◽  
pp. S-542-S-543
Author(s):  
Lila G. Glotfelty ◽  
Sophia Simon ◽  
Aleksandra Golos ◽  
Maayan Levy
Keyword(s):  
Colorectal Cancer ◽  
Cancer Model

scholarly journals Alteration of Gene Expression in the Colon of Colorectal Cancer Model Rat by Dietary Sodium Gluconate

2006 ◽  
Vol 70 (3) ◽  
pp. 606-614 ◽  
Author(s):  
Chiyoko KAMEUE ◽  
Takamitsu TSUKAHARA ◽  
Kazunari USHIDA
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Dietary Sodium ◽  
Sodium Gluconate ◽  
Cancer Model
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