scholarly journals A case of congenital prothrombin deficiency with two concurrent mutations in the prothrombin gene

2021 ◽  
Author(s):  
Eman M. Mansory ◽  
Pratibha Bhai ◽  
Alan Stuart ◽  
Lori Laudenbach ◽  
Bekim Sadikovic ◽  
...  
Keyword(s):  
Prothrombin Gene

The 20210 A Allele of the Prothrombin Gene Is a Common Risk Factor among Swedish Outpatients with Verified Deep Venous Thrombosis

1997 ◽  
Vol 78 (03) ◽  
pp. 0990-0992 ◽  
Author(s):  
Andreas Hillarp ◽  
Bengt Zӧller ◽  
Peter J Svensson ◽  
Bjӧrn Dahlbäck
Keyword(s):  
Risk Factor ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Odds Ratio ◽  
Untranslated Region ◽  
Control Group ◽  
Common Risk Factor ◽  
Apc Resistance ◽  
Healthy Control ◽  
Prothrombin Gene

SummaryA dimorphism in the 3’-untranslated region of the prothrombin gene (G to A transition at position 20210) has recently been reported to be associated with increases in plasma prothrombin levels and in the risk of venous thrombosis (1). We have examined the prothrombin dimorphism among 99 unselected outpatients with phlebography verified deep venous thrombosis, and in 282 healthy controls. The prevalence of the 20210 A allele was 7.1% (7/99) in the patient group, and 1.8% (5/282) in the healthy control group (p = 0.0095). The relative risk of venous thrombosis was calculated to be 4.2 (95% Cl, 1.3 to 13.6), and was still significant when adjustment was made for age, sex and the factor V:R506Q mutation causing APC resistance [odds ratio 3.8 (95% Cl, 1.1 13.2)]. As previously reported, 28% of the patients were carriers of the factor V:R506Q mutation. Thus, 34% (one patient carried both traits) of unselected patients with deep venous thrombosis were carriers of an inherited prothrombotic disorder. To sum up, our results confirm the 20210 A allele of the prothrombin gene to be an important risk factor for venous thrombosis.

scholarly journals The A20210 Allele of the Prothrombin Gene Is Frequently Associated With the Factor V Arg 506 to Gln Mutation But Not With Protein S Deficiency in Thrombophilic Families

Blood ◽  
1998 ◽  
Vol 91 (6) ◽  
pp. 2210-2211 ◽  
Author(s):  
Bengt Zöller ◽  
Peter J. Svensson ◽  
Björn Dahlbäck ◽  
Andreas Hillarp
Keyword(s):  
Protein S ◽  
Factor V ◽  
Protein S Deficiency ◽  
S Deficiency ◽  
Prothrombin Gene

The prevalence of the prothrombin gene variant C20209T in African-Americans and Caucasians and lack of association with venous thromboembolism

2006 ◽  
Vol 118 (6) ◽  
pp. 767-768 ◽  
Author(s):  
W. Craig Hooper ◽  
Stacy Roberts ◽  
Nicole Dowling ◽  
Harland Austin ◽  
Cathy Lally ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
African Americans ◽  
Gene Variant ◽  
Prothrombin Gene

scholarly journals Structure and evolution of the bovine prothrombin gene

1988 ◽  
Vol 200 (1) ◽  
pp. 31-45 ◽  
Author(s):  
David M. Irwin ◽  
Katherine A. Robertson ◽  
Ross T.A. MacGillivray
Keyword(s):  
Prothrombin Gene

Markers of activated coagulation in patients with factor V Leiden and/or G20210A prothrombin gene mutation

2002 ◽  
Vol 107 (1-2) ◽  
pp. 7-11 ◽  
Author(s):  
I Gouin-Thibault ◽  
R Arkam ◽  
S Nassiri ◽  
A de la Tourette ◽  
J Conard ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Factor V Leiden ◽  
Factor V ◽  
Prothrombin Gene Mutation ◽  
Prothrombin Gene

scholarly journals Interaction Between the G20210A Mutation of the Prothrombin Gene and Oral Contraceptive Use in Deep Vein Thrombosis

1999 ◽  
Vol 19 (3) ◽  
pp. 700-703 ◽  
Author(s):  
Ida Martinelli ◽  
Emanuela Taioli ◽  
Paolo Bucciarelli ◽  
Sepideh Akhavan ◽  
Pier Mannuccio Mannucci
Keyword(s):  
Deep Vein Thrombosis ◽  
Oral Contraceptive ◽  
Contraceptive Use ◽  
Vein Thrombosis ◽  
Oral Contraceptive Use ◽  
G20210a Mutation ◽  
Prothrombin Gene ◽  
Deep Vein
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