scholarly journals Retracted: Tumor Tropism of Intravenously Injected Human-Induced Pluripotent Stem Cell-Derived Neural Stem Cells and Their Gene Therapy Application in a Metastatic Breast Cancer Model

Stem Cells ◽  
2012 ◽  
Vol 30 (5) ◽  
pp. 1021-1029 ◽  
Author(s):  
Jing Yang ◽  
Dang Hoang Lam ◽  
Sally Sallee Goh ◽  
Esther Xingwei Lee ◽  
Ying Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Pluripotent Stem Cell ◽  
Metastatic Breast ◽  
Induced Pluripotent Stem Cell ◽  
Cancer Model ◽  
Gene Therapy Application ◽  
Breast Cancer Model ◽  
Tumor Tropism ◽  
Induced Pluripotent

scholarly journals Combination of local, nonviral IL12 gene therapy and systemic paclitaxel treatment in a metastatic breast cancer model

2004 ◽  
Vol 9 (6) ◽  
pp. 829-836 ◽  
Author(s):  
Margit Maria Janát-Amsbury ◽  
James W Yockman ◽  
Minhyung Lee ◽  
Steven Kern ◽  
Darin Y Furgeson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Metastatic Breast Cancer ◽  
Metastatic Breast ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Paclitaxel Treatment

scholarly journals Targeted Inhibition of the miR-199a/214 Cluster by CRISPR Interference Augments the Tumor Tropism of Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Hypoxic Condition

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yumei Luo ◽  
Xuehu Xu ◽  
Xiuli An ◽  
Xiaofang Sun ◽  
Shu Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Stem Cell ◽  
Cell Migration ◽  
Neural Stem Cells ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Tumor Tropism ◽  
Targeted Inhibition ◽  
Induced Pluripotent

The human induced pluripotent stem cell (hiPSC) provides a breakthrough approach that helps overcoming ethical and allergenic challenges posed in application of neural stem cells (NSCs) in targeted cancer gene therapy. However, the tumor-tropic capacity of hiPSC-derived NSCs (hiPS-NSCs) still has much room to improve. Here we attempted to promote the tumor tropism of hiPS-NSCs by manipulating the activity of endogenous miR-199a/214 cluster that is involved in regulation of hypoxia-stimulated cell migration. We first developed a baculovirus-delivered CRISPR interference (CRISPRi) system that sterically blocked the E-box element in the promoter of the miR-199a/214 cluster with an RNA-guided catalytically dead Cas9 (dCas9). We then applied this CRISPRi system to hiPS-NSCs and successfully suppressed the expression of miR-199a-5p, miR-199a-3p, and miR-214 in the microRNA gene cluster. Meanwhile, the expression levels of their targets related to regulation of hypoxia-stimulated cell migration, such as HIF1A, MET, and MAPK1, were upregulated. Further migration assays demonstrated that the targeted inhibition of the miR-199a/214 cluster significantly enhanced the tumor tropism of hiPS-NSCs both in vitro and in vivo. These findings suggest a novel application of CRISPRi in NSC-based tumor-targeted gene therapy.

scholarly journals Antitumor Effects of CD40 Ligand-Expressing Endothelial Progenitor Cells Derived From Human Induced Pluripotent Stem Cells in a Metastatic Breast Cancer Model

2014 ◽  
Vol 3 (8) ◽  
pp. 923-935 ◽  
Author(s):  
Yovita Ida Purwanti ◽  
Can Chen ◽  
Dang Hoang Lam ◽  
Chunxiao Wu ◽  
Jieming Zeng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Metastatic Breast Cancer ◽  
Pluripotent Stem Cells ◽  
Metastatic Breast ◽  
Cd40 Ligand ◽  
Cancer Model ◽  
Antitumor Effects ◽  
Breast Cancer Model ◽  
Induced Pluripotent

scholarly journals Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model

2000 ◽  
Vol 7 (7) ◽  
pp. 1086-1099 ◽  
Author(s):  
Anish Sen Majumdar ◽  
Alya Zolotorev ◽  
Sara Samuel ◽  
Kimvan Tran ◽  
Beth Vertin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Metastatic Breast Cancer ◽  
Herpes Simplex ◽  
Metastatic Breast ◽  
Cytokine Gene ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Cytokine Gene Therapy ◽  
Simplex Virus

scholarly journals Visualisation of Sentinel Lymph Node with Indium-Based near Infrared Emitting Quantum Dots in a Murine Metastatic Breast Cancer Model

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e44433 ◽  
Author(s):  
Marion Helle ◽  
Elsa Cassette ◽  
Lina Bezdetnaya ◽  
Thomas Pons ◽  
Agnès Leroux ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quantum Dots ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Near Infrared ◽  
Metastatic Breast ◽  
Cancer Model ◽  
Breast Cancer Model

scholarly journals 68Ga-Sienna+ for PET-MRI Guided Sentinel Lymph Node Biopsy: Synthesis and Preclinical Evaluation in a Metastatic Breast Cancer Model

2019 ◽  
Vol 3 (3) ◽  
pp. 255-265
Author(s):  
Heli Savolainen ◽  
Alessia Volpe ◽  
Alkystis Phinikaridou ◽  
Michael Douek ◽  
Gilbert Fruhwirth ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Metastatic Breast ◽  
Lymph Node Biopsy ◽  
Cancer Model ◽  
Preclinical Evaluation ◽  
Node Biopsy ◽  
Breast Cancer Model ◽  
Mri Guided

scholarly journals Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model

2020 ◽  
Vol 21 (10) ◽  
pp. 3479 ◽  
Author(s):  
Elisa Roda ◽  
Fabrizio De Luca ◽  
Carmine Di Iorio ◽  
Daniela Ratto ◽  
Stella Siciliani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Lentinula Edodes ◽  
Metastatic Breast ◽  
Medicinal Mushroom ◽  
Cancer Model ◽  
Pulmonary Tissue ◽  
Markers Of Inflammation ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer

Although medicinal mushroom extracts have been proposed as promising anti-cancer agents, their precise impacts on metastatic breast cancer are still to be clarified. For this purpose, the present study exploited the effect of a novel medicinal mushroom blend, namely Micotherapy U-care, in a 4T1 triple-negative mouse breast cancer model. Mice were orally administered with Micotherapy U-care, consisting of a mixture of Agaricus blazei, Ophiocordyceps sinensis, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes. The syngeneic tumor-bearing mice were generated by injecting 4T1 cells in both supplemented and non-supplemented mice. After sacrifice 35 days later, specific endpoints and pathological outcomes of the murine pulmonary tissue were evaluated. (i) Histopathological and ultrastructural analysis and (ii) immunohistochemical assessment of TGF-ß1, IL-6 and NOS2, COX2, SOD1 as markers of inflammation and oxidative stress were performed. The QoL was comparatively evaluated. Micotherapy U-care supplementation, starting before 4T1 injection and lasting until the end of the experiment, dramatically reduced the pulmonary metastases density, also triggering a decrease of fibrotic response, and reducing IL-6, NOS, and COX2 expression. SOD1 and TGF-ß1 results were also discussed. These findings support the valuable potential of Micotherapy U-care as adjuvant therapy in the critical management of triple-negative breast cancer.

Abstract 475: Resection of primary tumor improves survival in mouse metastatic breast cancer model

2010 ◽  
Author(s):  
Omar M. Rashid ◽  
Masayuki Nagahashi ◽  
Subramaniam Ramachandran ◽  
Sheldon Milstien ◽  
Sarah Spiegel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Primary Tumor ◽  
Metastatic Breast ◽  
Cancer Model ◽  
Breast Cancer Model

Abstract 2506: Preclinical evaluation of sorafenib in combination with ionizing radiation in metastatic breast cancer model

2011 ◽  
Author(s):  
Mitra Heravi ◽  
Thierry Muanza ◽  
Nada Tomic ◽  
LiHeng Liang ◽  
Joseph Holmes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Ionizing Radiation ◽  
Metastatic Breast ◽  
Cancer Model ◽  
Preclinical Evaluation ◽  
Breast Cancer Model
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