Demineralized bone matrix and human cancellous bone enhance fixation of porous-coated titanium implants in sheep

2013 ◽  
Vol 10 (3) ◽  
pp. 245-251 ◽  
Author(s):  
Hassan Babiker ◽  
Ming Ding ◽  
Søren Overgaard
Keyword(s):  
Cancellous Bone ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Titanium Implants ◽  
Human Cancellous Bone ◽  
Demineralized Bone

scholarly journals Fabrication of Demineralized Bone Matrix/Polycaprolactone Composites Using Large Area Projection Sintering (LAPS)

2019 ◽  
Vol 3 (2) ◽  
pp. 30 ◽  
Author(s):  
Mohsen Ziaee ◽  
Rebecca Hershman ◽  
Ayesha Mahmood ◽  
Nathan B. Crane
Keyword(s):  
Additive Manufacturing ◽  
Cancellous Bone ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Bone Allograft ◽  
Layer By Layer ◽  
Large Area ◽  
Manufacturing Method ◽  
Synthetic Scaffolds ◽  
Demineralized Bone

Cadaveric decellularized bone tissue is utilized as an allograft in many musculoskeletal surgical procedures. Typically, the allograft acts as a scaffold to guide tissue regeneration with superior biocompatibility relative to synthetic scaffolds. Traditionally these scaffolds are machined into the required dimensions and shapes. However, the geometrical simplicity and, in some cases, limited dimensions of the donated tissue restrict the use of allograft scaffolds. This could be overcome by additive manufacturing using granulated bone that is both decellularized and demineralized. In this study, the large area projection sintering (LAPS) method is evaluated as a fabrication method to build porous structures composed of granulated cortical bone bound by polycaprolactone (PCL). This additive manufacturing method utilizes visible light to selectively cure the deposited material layer-by-layer to create 3D geometry. First, the spreading behavior of the composite mixtures is evaluated and the conditions to attain improved powder bed density to fabricate the test specimens are determined. The tensile strength of the LAPS fabricated samples in both dry and hydrated states are determined and compared to the demineralized cancellous bone allograft and the heat treated demineralized-bone/PCL mixture in mold. The results indicated that the projection sintered composites of 45–55 wt %. Demineralized bone matrix (DBM) particulates produced strength comparable to processed and demineralized cancellous bone.

Comparison of bone healing by demineralized bone matrix and autogenous cancellous bone in horses

2000 ◽  
Vol 29 (3) ◽  
pp. 218-226 ◽  
Author(s):  
Christopher E. Kawcak ◽  
Gayle W. Trotter ◽  
Barbara E. Powers ◽  
Richard D. Park ◽  
A. Simon Turner
Keyword(s):  
Cancellous Bone ◽  
Bone Healing ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Demineralized Bone

scholarly journals Fibrous Demineralized Bone Matrix (DBM) Improves Bone Marrow Mononuclear Cell (BMC)-Supported Bone Healing in Large Femoral Bone Defects in Rats

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1249
Author(s):  
René D. Verboket ◽  
Tanja Irrle ◽  
Yannic Busche ◽  
Alexander Schaible ◽  
Katrin Schröder ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Calcium Phosphate ◽  
Cancellous Bone ◽  
Bone Healing ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Bone Defects ◽  
Bone Marrow Mononuclear Cell ◽  
Femoral Bone ◽  
Demineralized Bone

Regeneration of large bone defects is a major objective in trauma surgery. Bone marrow mononuclear cell (BMC)-supported bone healing was shown to be efficient after immobilization on a scaffold. We hypothesized that fibrous demineralized bone matrix (DBM) in various forms with BMCs is superior to granular DBM. A total of 65 male SD rats were assigned to five treatment groups: syngenic cancellous bone (SCB), fibrous demineralized bone matrix (f-DBM), fibrous demineralized bone matrix densely packed (f-DBM 120%), DBM granules (GDBM) and DBM granules 5% calcium phosphate (GDBM5%Ca2+). BMCs from donor rats were combined with different scaffolds and placed into 5 mm femoral bone defects. After 8 weeks, bone mineral density (BMD), biomechanical stability and histology were assessed. Similar biomechanical properties of f-DBM and SCB defects were observed. Similar bone and cartilage formation was found in all groups, but a significantly bigger residual defect size was found in GDBM. High bone healing scores were found in f-DBM (25) and SCB (25). The application of DBM in fiber form combined with the application of BMCs shows promising results comparable to the gold standard, syngenic cancellous bone. Denser packing of fibers or higher amount of calcium phosphate has no positive effect.

Osseous Healing Using Injectable Calcium Sulfate-Based Putty for the Delivery of Demineralized Bone Matrix and Cancellous Bone Chips

Orthopedics ◽  
2003 ◽  
Vol 26 (5) ◽  
Author(s):  
Thomas M Turner ◽  
Robert M Urban ◽  
Deborah J Hall ◽  
Susan Infanger ◽  
Steven Gitelis ◽  
...  
Keyword(s):  
Cancellous Bone ◽  
Calcium Sulfate ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Demineralized Bone

scholarly journals Osteoformation potential of an allogenic partially demineralized bone matrix in critical-size defects in the rat calvarium

2021 ◽  
pp. 112207
Author(s):  
Ahmad Moustapha Diallo ◽  
Solène Rota ◽  
Michel Boissière ◽  
Raphaël Bardonnet ◽  
Emmanuel Pauthe ◽  
...  
Keyword(s):  
Critical Size ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Critical Size Defects ◽  
Demineralized Bone

Comparative Assessment of Autogenous Cancellous Bone Graft and Bovine-Derived Demineralized Bone Matrix for Secondary Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate

2021 ◽  
pp. 105566562110251
Author(s):  
Vijay Kumar ◽  
Vidya Rattan ◽  
Sachin Rai ◽  
Satinder Pal Singh ◽  
Jai Kumar Mahajan
Keyword(s):  
Bone Graft ◽  
Iliac Crest ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Volumetric Analysis ◽  
Group I ◽  
Alveolar Bone Grafting ◽  
Group Ii ◽  
Demineralized Bone

Objective: Comparison between bovine-derived demineralized bone matrix (DMBM) and iliac crest graft over long term for secondary alveolar bone grafting (SABG) in patients with unilateral cleft lip and palate (UCLP) in terms of radiological and clinical outcomes. Design: Prospective, randomized, parallel groups, double-blind, controlled trial. Setting: Unit of Oral and Maxillofacial Surgery, Oral Health Science Centre, Postgraduate Institute of Medical Education & Research, Chandigarh. Participants: Twenty patients with UCLP. Interventions: Patients were allocated into group I (Iliac crest bone graft) and group II (DMBM) for SABG. Outcomes were assessed at 2 weeks, 6 months, and then after mean follow-up period of 63 months. Outcomes Measures: Volumetric analysis of the grafted bone in the alveolar cleft site was done through cone beam computed tomography using Cavalieri principle and modified assessment tool. Clinical assessment was performed in terms of pain, swelling, duration of hospital stay, cost of surgery, alar base symmetry, and donor site morbidity associated with iliac crest harvesting. Results: Volumetric analysis through Cavalieri principle revealed comparable bone uptake at follow-up of 6 months between group I (70%) and group II (69%). Modified assessment tool showed no significant difference between horizontal and vertical bone scores over short- and long-term follow-up. In group II, there was higher cost of surgery, but no donor site morbidity unlike group I. Conclusions: Demineralized bone matrix proved analogous to iliac crest bone graft as per volumetric analysis over shorter period. However, although statistically insignificant, net bone volume achieved was lower than the iliac crest graft at longer follow-up.

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