Progenitor-derived endothelial cell response, platelet reactivity and haemocompatibility parameters indicate the potential of NaOH-treated polycaprolactone for vascular tissue engineering

2011 ◽  
Vol 5 (3) ◽  
pp. 238-247 ◽  
Author(s):  
María-Concepción Serrano ◽  
Raffaella Pagani ◽  
Juan Peña ◽  
María Vallet-Regí ◽  
Juan-Valentín Comas ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Endothelial Cell ◽  
Cell Response ◽  
Vascular Tissue ◽  
Platelet Reactivity ◽  
Vascular Tissue Engineering ◽  
Endothelial Cell Response

scholarly journals PLLA/Fibrin Tubular Scaffold: A New Way for Reliable Endothelial Cell Seeding

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Salvatrice Rigogliuso ◽  
Francesco Carfì Pavia ◽  
Vincenzo La Carrubba ◽  
Valerio Brucato ◽  
Giulio Ghersi
Keyword(s):  
Tissue Engineering ◽  
Endothelial Cell ◽  
Vascular Tissue ◽  
Porous Wall ◽  
Vascular Tissue Engineering ◽  
Cell Seeding ◽  
Fibrin Gel ◽  
Engineering Applications ◽  
Hybrid Scaffold

In the present work a simple and quick technique for cell seeding into tubular-shaped scaffolds, which allows a homogeneous cell distribution, was tested. The poly-L-lactide (PLLA) scaffolds, prepared via diffusion induced phase separation (DIPS), were filled with fibrin gel in order to obtain a hybrid scaffold for Vascular Tissue Engineering applications. The formation of immobilized fibrin networks on the inner surface of the tubular scaffolds was observed using confocal microscopy and SEM. Morphological analysis of the so-obtained scaffold revealed that the fibrin gel is uniformly distributed on the internal surface of the scaffold, leading to an organized structure. Moreover a penetration of the gel into the porous wall of the scaffold was observed. The in vitro endothelial cell cultures carried out in the scaffolds highlighted a faster cell proliferation inside the hybrid scaffold with respect to simple PLLA scaffold. Results show that the fibrin/PLLA hybrid scaffold may be favourably used for Vascular Tissue Engineering applications.

Vascular tissue engineering: Biomechanical studies on autologeous small-calibred vessels

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
K Kallenbach ◽  
J Heine ◽  
E Lefik ◽  
S Cebotari ◽  
A Lichtenberg ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering
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