Treatment of cardiovascular disease has achieved great success using artificial implants,
particularly synthetic-polymer made grafts. However, thrombus formation and
restenosis are the current clinical problems need to be conquered. New biomaterials, modifying
the surface of synthetic vascular grafts, have been created to improve long-term patency
for the better hemocompatibility. The vascular biomaterials can be fabricated from synthetic
or natural polymers for vascular tissue engineering. Stem cells can be seeded by different
techniques into tissue-engineered vascular grafts in vitro and implanted in vivo to repair the
vascular tissues. To overcome the thrombogenesis and promote the endothelialization
effect, vascular biomaterials employing nanotopography are more bio-mimic to the native tissue
made and have been engineered by various approaches such as prepared as a simple surface
coating on the vascular biomaterials. It has now become an important and interesting
field to find novel approaches to better endothelization of vascular biomaterials. In this article,
we focus to review the techniques with better potential improving endothelization and summarize
for vascular biomaterial application. This review article will enable the development
of biomaterials with a high degree of originality, innovative research on novel techniques for
surface fabrication for vascular biomaterials application.
Effects of S1P on endothelial cell reattachment on de‐cellularized HUV scaffold for vascular tissue engineering (867.13)
