Cytotoxic effects and apoptosis induction of atrazine in a grass carp (Ctenopharyngodon idellus) cell line

Plants with anticancer properties are considered as cancer preventive and treatment sources, due to their some biological effects. Apoptosis induction and anti-proliferative effects of Baneh extract on various cancer cell lines have been reported. Hence, this study was designed to evaluate the cytotoxic effects of this fruit on KB and human gingival fibroblast cell lines (HGF). KB and HGF cells were treated with various concentrations of ethanolic Baneh extract and cisplatin as positive control. Cytotoxic activity and apoptosis induction were investigated using WST-1 and Annexin V assays. Data were analyzed using ANOVA and student’s t-tests. IC50 after 24 and 48 hours treatment were respectively 2.6 and 1 mg/mL for KB cell line, and 1.5 and 1.6 mg/mL for HGF cell. During 48 hours Baneh extract induced apoptosis without significant necrosis, in a time- and dose-dependent manner. The induction of apoptosis in KB cells was significantly higher than HGF. It seems that ethanolic extract of Baneh contains compounds that can suppress KB cell growth through the induction of apoptosis. Within 48 hours, less cytotoxic effects were observed on normal fibroblast cells; therefore, it might be a potential anticancer agent.

Download Full-text

Establishment of a cell line from swim bladder of the Grass carp (Ctenopharyngodon idellus) for propagation of Grass Carp Reovirus Genotype II

Microbial Pathogenesis ◽

10.1016/j.micpath.2021.104739 ◽

2021 ◽

Vol 151 ◽

pp. 104739

Author(s):

Yuru Yang ◽

Yingying Wang ◽

Qing Wang ◽

Weiwei Zeng ◽

Yingying Li ◽

...

Keyword(s):

Cell Line ◽

Grass Carp ◽

Swim Bladder ◽

Ctenopharyngodon Idellus ◽

Grass Carp Reovirus ◽

A Cell ◽

Genotype Ii

Download Full-text

Grass carp reovirus induces apoptosis and oxidative stress in grass carp (Ctenopharyngodon idellus) kidney cell line

Virus Research ◽

10.1016/j.virusres.2014.03.021 ◽

2014 ◽

Vol 185 ◽

pp. 77-81 ◽

Cited By ~ 25

Author(s):

Rui Jia ◽

Li-Ping Cao ◽

Jin-Liang Du ◽

Ying-Juan Liu ◽

Jia-Hao Wang ◽

...

Keyword(s):

Oxidative Stress ◽

Cell Line ◽

Kidney Cell ◽

Grass Carp ◽

Ctenopharyngodon Idellus ◽

Kidney Cell Line ◽

Grass Carp Reovirus ◽

And Oxidative Stress

Download Full-text

Involvement of apoptosis in malathion-induced cytotoxicity in a grass carp (Ctenopharyngodon idellus) cell line

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology ◽

10.1016/j.cbpc.2005.10.010 ◽

2006 ◽

Vol 142 (1-2) ◽

pp. 36-45 ◽

Cited By ~ 20

Author(s):

Xiao-yong Chen ◽

Jian-zhong Shao ◽

Li-xin Xiang ◽

Xin-mei Liu

Keyword(s):

Cell Line ◽

Grass Carp ◽

Ctenopharyngodon Idellus

Download Full-text

Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp (Ctenopharyngodon idellus) via suppression of oxidative stress, inflammation and apoptosis

Food & Function ◽

10.1039/d0fo01638a ◽

2020 ◽

Vol 11 (10) ◽

pp. 8547-8559

Author(s):

Hongjing Zhao ◽

Yu Wang ◽

Mengyao Mu ◽

Menghao Guo ◽

Hongxian Yu ◽

...

Keyword(s):

Oxidative Stress ◽

Secondary Metabolites ◽

Human Health ◽

Grass Carp ◽

Aquatic Environment ◽

Ctenopharyngodon Idellus

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health.

Download Full-text