Cadmium and nickel co‐exposure exacerbates genotoxicity and not oxido‐inflammatory stress in liver and kidney of rats: Protective role of omega‐3 fatty acid

2019 ◽  
Vol 35 (2) ◽  
pp. 231-241 ◽  
Author(s):  
Solomon E. Owumi ◽  
Yusuff O. Olayiwola ◽  
Gbenga E. Alao ◽  
Michael A. Gbadegesin ◽  
Oyeronke A. Odunola
Keyword(s):  
Fatty Acid ◽  
Protective Role ◽  
Omega 3 ◽  
Inflammatory Stress ◽  
Omega 3 Fatty Acid ◽  
Liver And Kidney

Abstract 168: Impact of Continuing Medical Education on the Treatment of Hypertriglyceridemia with Omega-3 Fatty Acids

2016 ◽  
Vol 9 (suppl_2) ◽  
Author(s):  
Amy Larkin ◽  
Michael LaCouture ◽  
George Boutsalis ◽  
Harold Bays
Keyword(s):  
Fatty Acids ◽  
Medical Education ◽  
Fatty Acid ◽  
Online Education ◽  
Continuing Medical Education ◽  
Primary Care Physicians ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega 3 Fatty Acid

Introduction: The less prominent role of triglycerides in determining cardiovascular risk keeps these lipids from being top-of-mind for practicing clinicians, yet epidemiologic data affirm that hypertriglyceridemia contributes to atherosclerotic disease development and progression. We sought to determine if online continuing medical education (CME) could improve the clinical knowledge and competence of primary care physicians (PCPs) and cardiologists regarding hypertriglyceridemia and the use of omega-3 fatty acids in its treatment. Methods: The effects of two educational interventions about advances in hypertriglyceridemia treatment (activity 1) and educating patients about omega-3 fatty acid products (activity 2) were analyzed to determine efficacy of online education presented in the form of online video-based roundtable discussions. The activities launched online in May and June, 2015 respectively, and data were collected through July, 2015. The effects of education were assessed using knowledge- and case-based matched pre-assessment/post-assessments. The effect sizes were calculated with Cohen’s d (> 0.8 is large, 0.8-0.4 is medium, and < 0.4 is small). Results: In total, 842 PCPs and 75 cardiologists who completed all pre/post assessment questions in any of the two activities during the study period were included in analyses. Significant overall improvements were seen for PCPs (activity 1: n = 452, P <.05, effect d= 0.68; activity 2: n = 390, P <.05, effect d= 0.96) and cardiologists (activity 1: n = 35, P <.05, effect d= 0.77; activity 2: n = 40, P <.05, effect d= 0.9). Compared with baseline, specific areas of improvements include: • 22% more PCPs and 31% more cardiologists identified weight loss as a nonpharmacological intervention that can effectively lower triglyceride levels for overweight/obese patients with hypertriglyceridemia, (both P < .05) • 35% more PCPs and 32% more cardiologists identified the appropriate dosing of prescription omega-3 fatty acids (both P <.05) • 23% more PCPs ( P < .05) and 20% more cardiologists ( P =.068 ) recognized that reducing the risk for pancreatitis is a primary medical objective in patients with severe elevations in triglyceride levels Areas identified as needing additional education include: • 57% of all physicians remain unaware that omega-3 fatty acids reduce apolipoprotein C3 • 61% of PCPs and 60% of cardiologists did not demonstrate a thorough understanding of the differences between prescription omega-3 fatty acids and omega-3 supplements Conclusion: This study demonstrates the success of a targeted educational intervention with two educational components on improving knowledge, competence, and clinical decision-making of PCPs and cardiologists regarding hypertriglyceridemia treatment and the role of omega-3 fatty acid products in its treatment.

Can A Nutritional Factor Modulate The Hdl Functionality: Role Of Omega-3 Fatty Acid

2019 ◽  
Vol 287 ◽  
pp. e226
Author(s):  
N.R.T. Damasceno ◽  
F.D.C. Cartolano ◽  
G.D. Dias ◽  
A.O.C. Ventura ◽  
A.P.D.Q. Mello
Keyword(s):  
Fatty Acid ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Hdl Functionality ◽  
Nutritional Factor

Role of β-catenin signaling in the anti-invasive effect of the omega-3 fatty acid DHA in human melanoma cells

2016 ◽  
Vol 84 (2) ◽  
pp. 149-159 ◽  
Author(s):  
Simona Serini ◽  
Antonio Zinzi ◽  
Renata Ottes Vasconcelos ◽  
Elena Fasano ◽  
Maria Greca Riillo ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Human Melanoma Cells

scholarly journals Role of Omega-3 Fatty Acid Supplementation in Inflammation and Malignancy

2004 ◽  
Vol 3 (2) ◽  
pp. 98-111 ◽  
Author(s):  
David H. Jho ◽  
Shawn M. Cole ◽  
Ellyn M. Lee ◽  
N. Joseph Espat
Keyword(s):  
Fatty Acid ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid

scholarly journals ROLE OF OMEGA-3 FATTY ACID IN DRY EYE SYNDROME ASSOCIATED WITH MEIBOMITIS

2016 ◽  
Vol 5 (67) ◽  
pp. 4790-4792
Author(s):  
Garima Rai ◽  
Deepak Mishra ◽  
Ketki Khandhadiya ◽  
Shailesh Kumar
Keyword(s):  
Fatty Acid ◽  
Dry Eye ◽  
Dry Eye Syndrome ◽  
Omega 3 ◽  
Omega 3 Fatty Acid

scholarly journals Role of OMEGA-3 Fatty Acid Supplementation in COVID-19 Patients: A Narrative Review

2021 ◽  
Vol 04 (02) ◽  
Author(s):  
Zoia Akram ◽  
Alekhya Allenki ◽  
Sindhu Kishore ◽  
Dolly Ogwu ◽  
Olufunlola Titilayo Adefalu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Narrative Review ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid

scholarly journals Seafood, fatty acid biosynthesis genes, and multiple sclerosis susceptibility

2019 ◽  
Vol 26 (12) ◽  
pp. 1476-1485
Author(s):  
Annette Langer-Gould ◽  
Lucinda J Black ◽  
Emmanuelle Waubant ◽  
Jessica B Smith ◽  
Jun Wu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Fatty Acid ◽  
Fish Oil ◽  
Fatty Acid Biosynthesis ◽  
Nucleotide Polymorphisms ◽  
Omega 3 ◽  
Kaiser Permanente ◽  
Omega 3 Fatty Acid ◽  
Fish Oil Supplementation

Background: The role of omega-3 fatty acid in multiple sclerosis (MS) susceptibility is unclear. Objective: To determine whether fish/seafood intake or genetic factors that regulate omega-3 fatty acids levels are associated with MS risk. Methods: We examined the association of fish and shrimp consumption and 13 tag single nucleotide polymorphisms (SNPs) in FADS1, FADS2, and ELOV2 with risk of MS in 1153 individuals from the MS Sunshine Study, a case-control study of incident MS or clinically isolated syndrome (CIS), recruited from Kaiser Permanente Southern California. Results: Consuming fish/seafood at least once a week or at least once a month with regular fish oil use was associated with 44% reduced odds of MS/CIS (adjusted OR = 0.56; 95% CI = 0.41–0.76; p = 0.0002) compared with consuming fish/seafood less than once a month and no fish oil supplementation. Two FADS2 SNPs (rs174611 and rs174618) were independently associated with a lower risk of MS (adjusted ORs = 0.74, 0.79, p = 0.0056, 0.0090, respectively). Association of FADS2 SNPs with MS risk was confirmed in an independent dataset. Conclusion: These findings suggest that omega-3 fatty acid intake may be an important modifiable risk factor for MS. This is consistent with the other known health benefits of fish consumption and complementary genetic studies supporting a key role for omega-3 regulation.

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