Citral inhibits N‐nitrosodiethylamine‐induced hepatocellular carcinoma via modulation of antioxidants and xenobiotic‐metabolizing enzymes

2020 ◽  
Vol 35 (9) ◽  
pp. 971-981 ◽  
Author(s):  
Palanisamy Krishnan ◽  
Jagan Sundaram ◽  
Sharmila Salam ◽  
Nirmala Subramaniam ◽  
Ashok Mari ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes

Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers

2019 ◽  
Vol 130 ◽  
pp. 32-43 ◽  
Author(s):  
Elias Begas ◽  
Maria Bounitsi ◽  
Thomas Kilindris ◽  
Evangelos Kouvaras ◽  
Konstantinos Makaritsis ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Crocus Sativus ◽  
Short Term ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Crocus Sativus L

scholarly journals Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy

2015 ◽  
Vol 61 (3) ◽  
pp. 381-383 ◽  
Author(s):  
I.V. Zverinsky ◽  
H.G. Zverinskaya ◽  
I.P. Sutsko ◽  
P.G. Telegin ◽  
A.G. Shlyahtun
Keyword(s):  
Cytochrome P450 ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Compensatory Growth ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Recovery Processes

We have studied the effect of berberine on the recovery processes of liver xenobiotic-metabolizing function during its compensatory growth after 70% partial hepatectomy. It was found the hepatic ability to metabolize foreign substances are not restored up to day 8. Administration of berberine (10 mg/kg intraperitoneally) for 6 days led to normalization of both cytochrome P450-dependent and flavin-containing monooxygenases. It is suggested that in the biotransformation of berberine involved not only cytochrome P450, but also flavin-containing monooxygenases.

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