Butyrate interacts with benzo[a]pyrene to alter expression and activities of xenobiotic metabolizing enzymes involved in metabolism of carcinogens within colon epithelial cell models

Toxicology ◽  
2019 ◽  
Vol 412 ◽  
pp. 1-11 ◽  
Author(s):  
Ondřej Zapletal ◽  
Jiřina Procházková ◽  
Vít Dubec ◽  
Jiřina Hofmanová ◽  
Alois Kozubík ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Models ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Colon Epithelial Cell

Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models

2016 ◽  
Vol 91 (5) ◽  
pp. 2135-2150 ◽  
Author(s):  
Ondřej Zapletal ◽  
Zuzana Tylichová ◽  
Jiří Neča ◽  
Jiří Kohoutek ◽  
Miroslav Machala ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Epithelial Cell ◽  
Histone Deacetylase ◽  
Cell Models ◽  
Cytochrome P450 1A1 ◽  
Colon Epithelial Cell

n-3 Polyunsaturated fatty acids alter benzo[a]pyrene metabolism and genotoxicity in human colon epithelial cell models

2019 ◽  
Vol 124 ◽  
pp. 374-384 ◽  
Author(s):  
Zuzana Tylichová ◽  
Jiří Neča ◽  
Jan Topinka ◽  
Alena Milcová ◽  
Jiřina Hofmanová ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Epithelial Cell ◽  
Polyunsaturated Fatty Acids ◽  
Human Colon ◽  
Cell Models ◽  
Colon Epithelial Cell

Activities of drug metabolizing enzymes in bovine colon epithelial cell cultures

2003 ◽  
Vol 77 (11) ◽  
pp. 621-629 ◽  
Author(s):  
Sascha Birkner ◽  
Susanne Weber ◽  
Angelika Dohle ◽  
G�nter Schmahl ◽  
Hermann Maximilian Bolt ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Cultures ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Epithelial Cell Cultures ◽  
Colon Epithelial Cell

Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers

2019 ◽  
Vol 130 ◽  
pp. 32-43 ◽  
Author(s):  
Elias Begas ◽  
Maria Bounitsi ◽  
Thomas Kilindris ◽  
Evangelos Kouvaras ◽  
Konstantinos Makaritsis ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Crocus Sativus ◽  
Short Term ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Crocus Sativus L

RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models

2009 ◽  
Vol 61 (5) ◽  
pp. 583-591 ◽  
Author(s):  
Sibylle Endter ◽  
Danielle Francombe ◽  
Carsten Ehrhardt ◽  
Mark Gumbleton
Keyword(s):  
Epithelial Cell ◽  
Human Lung ◽  
Drug Transporters ◽  
Lung Epithelial Cell ◽  
Pcr Analysis ◽  
Cell Models ◽  
Rt Pcr ◽  
Human Lung Epithelial Cell ◽  
Lung Epithelial

scholarly journals Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy

2015 ◽  
Vol 61 (3) ◽  
pp. 381-383 ◽  
Author(s):  
I.V. Zverinsky ◽  
H.G. Zverinskaya ◽  
I.P. Sutsko ◽  
P.G. Telegin ◽  
A.G. Shlyahtun
Keyword(s):  
Cytochrome P450 ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Compensatory Growth ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Recovery Processes

We have studied the effect of berberine on the recovery processes of liver xenobiotic-metabolizing function during its compensatory growth after 70% partial hepatectomy. It was found the hepatic ability to metabolize foreign substances are not restored up to day 8. Administration of berberine (10 mg/kg intraperitoneally) for 6 days led to normalization of both cytochrome P450-dependent and flavin-containing monooxygenases. It is suggested that in the biotransformation of berberine involved not only cytochrome P450, but also flavin-containing monooxygenases.

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