Xanthorrhizol inhibits non‐small cell carcinoma ( A 549) cell growth and promotes apoptosis through modulation of PI3K/AKT and NF‐κB signaling pathway

2021 ◽  
Author(s):  
Yong Cai ◽  
Zhaoying Sheng ◽  
Jiying Wang
Keyword(s):  
Cell Growth ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Small Cell Carcinoma ◽  
Small Cell

The Effect of T-7 Peptide on Human Non-Small-Cell Carcinoma A549 Cells

2013 ◽  
Vol 641-642 ◽  
pp. 820-823
Author(s):  
Shu Jing Wang ◽  
Shan Jiang ◽  
Jia Liu ◽  
Fei Wang ◽  
Ning Chen ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
A549 Cell ◽  
Umbilical Vein ◽  
A549 Cells ◽  
Small Cell ◽  
Transmission Electron ◽  
Apoptotic Morphology ◽  
Umbilical Vein Endothelial Cells

7 peptide of Tumstatin(T-7 peptide) is composed of 185-191 amino acids. To study T-7 peptide antitumor activity to human non-small-cell carcinoma(A549), T-7 peptide was designed and synthesized by amino acid synthesizer. Its purity ran up to 98.45% by HPLC and MS. The effect of T-7 peptide on A549 cell growth was observed by MTT assay, growth curve and transmission electron microscopy(TEM). T-7 peptide had the effects of suppressing A549 cell growth and promoting its apoptosis, showing dose- and time-dependent. Its IC50 was 92.84 μg/ml. TEM also revealed that A549 cell treated with T-7 peptide appeared apoptotic morphology,such as cell pyknosis and mitochondrial vacuoles formed. While T-7 peptide had little effect on human umbilical vein endothelial cells(ECV304). These researches were significant to treat human non-small-cell carcinoma in the future.

scholarly journals Transcriptomic analysis reveals a WNT signaling pathway-based gene signature prognostic for non-small cell carcinoma

Aging ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 19159-19172
Author(s):  
Gang Liu ◽  
Wenhui Xie ◽  
Mingming Jin ◽  
Ping Li ◽  
Liu Liu ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Small Cell Carcinoma ◽  
Wnt Signaling Pathway ◽  
Gene Signature ◽  
Small Cell ◽  
Transcriptomic Analysis

A Case of Small Cell Carcinoma of the Supraglottis

2010 ◽  
Vol 53 (12) ◽  
pp. 784
Author(s):  
Jong Chul Hong ◽  
Seo Hee Rha ◽  
Hyun-Jik Lee ◽  
Heon Soo Park
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell

Small Cell Carcinoma Manifesting as a Bulky Thoracic Mass in a Pregnant Woman: A Case Report

2006 ◽  
Vol 55 (5) ◽  
pp. 477
Author(s):  
In Jae Lee ◽  
Kwang Seok Eom ◽  
Seon Young Jeon ◽  
Im Kyung Hwang ◽  
Yul Lee ◽  
...  
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell

scholarly journals Bone marrow metastases in small cell carcinoma of the lung: frequency, description, and influence on chemotherapeutic toxicity and prognosis

Blood ◽  
1979 ◽  
Vol 53 (4) ◽  
pp. 677-686 ◽  
Author(s):  
DC Ihde ◽  
EB Simms ◽  
MJ Matthews ◽  
MH Cohen ◽  
PA Bunn ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Bone Marrow Metastases
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