VP28.05: Accuracy of qualitative and quantitative cranial utrasound signs at 11–14weeks in the screening of open spina bifida: systematic review, meta‐analysis

AbstractThe aim of this systematic review was to perform qualitative and quantitative analysis on the toxic effects of chloroquine (CQ) and hydroxychloroquine (HCQ) on skeletal muscles. We designed the study according to PRISMA guidelines. Studies for qualitative and quantitative analyses were selected according to the following inclusion criteria: English language; size of sample (> 5 patients), adult (> age of 18) patients, treated with CQ/HCQ for inflammatory diseases, and presenting and not presenting with toxic effects on skeletal muscles. We collected data published from 1990 to April 2020 using PubMed, Cochrane Library, EMBASE, and SciELO. Risk of bias for observational studies was assessed regarding the ROBIN-I scale. Studies with less than five patients (case reports) were selected for an additional qualitative analysis. We used the software Comprehensive Meta-Analysis at the confidence level of 0.05. We identified 23 studies for qualitative analysis (17 case-reports), and five studies were eligible for quantitative analysis. From case reports, 21 patients presented muscle weakness and confirmatory biopsy for CQ/HCQ induced myopathy. From observational studies, 37 patients out of 1,367 patients from five studies presented muscle weakness related to the use of CQ/HCQ, and 252 patients presented elevated levels of muscle enzymes (aldolase, creatine phosphokinase, and lactate dehydrogenase). Four studies presented data on 34 patients with confirmatory biopsy for drug-induced myopathy. No study presented randomized samples. The chronic use of CQ/HCQ may be a risk for drug-induced myopathy. There is substantiated need for proper randomized trials and controlled prospective studies needed to assess the clinical and subclinical stages of CQ/HCQ -induced muscle myopathy.

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Learning curves of open and endoscopic fetal spina bifida closure: systematic review and meta‐analysis

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.20389 ◽

2020 ◽

Vol 55 (6) ◽

pp. 730-739 ◽

Cited By ~ 10

Author(s):

L. Joyeux ◽

F. De Bie ◽

E. Danzer ◽

F. M. Russo ◽

A. Javaux ◽

...

Keyword(s):

Systematic Review ◽

Spina Bifida ◽

Meta Analysis ◽

Learning Curves

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Neurodevelopmental outcome of children with spina bifida aperta repaired prenatally vs postnatally: systematic review and meta-analysis

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.20188 ◽

2019 ◽

Vol 53 (3) ◽

pp. 293-301 ◽

Cited By ~ 10

Author(s):

A. Inversetti ◽

L. Van der Veeken ◽

D. Thompson ◽

K. Jansen ◽

F. Van Calenbergh ◽

...

Keyword(s):

Systematic Review ◽

Spina Bifida ◽

Meta Analysis ◽

Neurodevelopmental Outcome ◽

Spina Bifida Aperta

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Management of Instrument Sterilization Workflow in Endodontics: A Systematic Review and Meta-Analysis

International Journal of Dentistry ◽

10.1155/2020/5824369 ◽

2020 ◽

Vol 2020 ◽

pp. 1-20 ◽

Cited By ~ 2

Author(s):

Mario Dioguardi ◽

Diego Sovereto ◽

Gaetano Illuzzi ◽

Enrica Laneve ◽

Bruna Raddato ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Three Dimensional ◽

Qualitative And Quantitative Analysis ◽

Pulp Chamber ◽

Qualitative And Quantitative ◽

Operating Field ◽

Gutta Percha ◽

Single Use ◽

Dental Burs

Endodontic treatment consists of different working procedures, such as the isolation of the operating field, pulp chamber access, and cleaning and shaping phases with at last the need of a three-dimensional filling of the canals. Each step requires a series of single-use or sterilizable instruments. We have performed a systematic review of different sterilization and disinfection procedures aiming at drawing up a disinfection and sterilization procedure to be used on endodontic instruments. A search on PubMed and Scopus was carried out using the following keywords: “endodontic sterilization,” “endodontic autoclave,” “decontamination dental bur,” “sterilization dental burs,” and “gutta-percha points sterilization.” Eligible articles were included in the qualitative and quantitative analysis. Results of the meta-analysis showed that the most effective method in sterilization is autoclaving. The qualitative analysis showed that the use of single-use or first-use instruments requires presterilization or sterilization procedures, and for reusable tools, attention must be paid to the removal of debris deposited on the blades, not easy to remove manually.

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Diagnostic accuracy of intracranial translucency in detecting spina bifida: a systematic review and meta-analysis

Prenatal Diagnosis ◽

10.1002/pd.4883 ◽

2016 ◽

Vol 36 (11) ◽

pp. 991-996 ◽

Cited By ~ 26

Author(s):

Giuseppe M. Maruotti ◽

Gabriele Saccone ◽

Francesco D'Antonio ◽

Vincenzo Berghella ◽

Laura Sarno ◽

...

Keyword(s):

Systematic Review ◽

Spina Bifida ◽

Diagnostic Accuracy ◽

Meta Analysis ◽

Intracranial Translucency

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Systematic review protocol examining sex differences in survival among low birthweight newborns and infants in sub-Saharan Africa

BMJ Open ◽

10.1136/bmjopen-2019-036645 ◽

2020 ◽

Vol 10 (6) ◽

pp. e036645

Author(s):

Akalewold T Gebremeskel ◽

Arone W Fantaye ◽

Lena E Faust ◽

Sanni Yaya

Keyword(s):

Systematic Review ◽

Sex Differences ◽

Low Birthweight ◽

Data Extraction ◽

Meta Analysis ◽

Sub Saharan Africa ◽

African Countries ◽

Mortality And Morbidity ◽

Qualitative And Quantitative ◽

Sub Saharan

IntroductionIn sub-Saharan African countries, low birthweight (LBW) accounts for three-quarters of under-five mortality and morbidity. However, there is no systematic evidence of sex differences in LBW survival risk. The aim of this protocol is to outline the methodological process of a systematic review that will gather qualitative and quantitative data on sex differences in survival among LBW newborns and infants in sub-Saharan Africa.MethodsThis protocol adheres to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols reporting guidelines. We will conduct a systematic review to retrieve all qualitative and quantitative studies. Electronic search strategies are being finalised on 24 February 2020 for Ovid Medline and EMBASE, and on 28 February 2020 for CINAHL, Scopus and Global Health in collaboration with a Health Sciences librarian. The primary outcome of interest is indicating sex differences in survival among LBW newborns and infants. Secondary outcomes are sex-disaggregated differences in morbidity among LBW newborns and infants. Screening, data extraction and assessments of risk of bias will be performed independently. Narrative synthesis and a meta-analysis will be conducted with studies that are compatible based on population and outcome. The systematic review is focused on the analysis of secondary data and does not require ethics approval.Ethics and disseminationAs it will be a systematic review, without human participants’ involvement, there will be no requirement for ethical approval. The systematic review will present key evidence of sex-disaggregated differences in mortality and morbidity among LBW newborns and infants in sub-Saharan Africa. Programme managers, policy-makers and researchers can use the findings to evaluate LBW health outcomes in different sexes. The final manuscript will be disseminated through a peer-reviewed journal and scientific conferences.PROSPERO registration numberCRD42020163470

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Global Birth Prevalence of Spina Bifida by Folic Acid Fortification Status: A Systematic Review and Meta-Analysis

American Journal of Public Health ◽

10.2105/ajph.2015.302902a ◽

2016 ◽

Vol 106 (1) ◽

pp. 159-159 ◽

Cited By ~ 5

Author(s):

Callie A. M. Atta ◽

Kirsten M. Fiest ◽

Alexandra D. Frolkis ◽

Nathalie Jette ◽

Tamara Pringsheim ◽

...

Keyword(s):

Systematic Review ◽

Folic Acid ◽

Spina Bifida ◽

Meta Analysis ◽

Birth Prevalence ◽

Folic Acid Fortification

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Prevalence of Spina Bifida among Newborns in Africa: A Systematic Review and Meta-Analysis

Scientifica ◽

10.1155/2020/4273510 ◽

2020 ◽

Vol 2020 ◽

pp. 1-12

Author(s):

Mohammed Oumer ◽

Molla Taye ◽

Hailu Aragie ◽

Ashenafi Tazebew

Keyword(s):

Systematic Review ◽

Spina Bifida ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Fetal Loss ◽

Cochrane Library ◽

Forest Plot ◽

Birth Prevalence ◽

Pooled Prevalence

Spina bifida is an abnormal closure of the neural tube during the fourth week of development. It is the major cause of fetal loss and considerable disabilities in newborns. The aim of this review is to determine the pooled prevalence of spina bifida among newborns in Africa. PubMed/Medline, Google Scholar, Science Direct, Joanna Briggs Institute (JBI) Library, Cochrane Library, Web of Science, African Journals Online, and Embase databases were systematically searched. Cochran Q test and I2 test statistics were applied to assess heterogeneity across studies. A random-effect model was applied to calculate the pooled prevalence of spina bifida. Forest plot and Galbraith’s plot were used to visualize heterogeneity. Subgroup, sensitivity, meta-regression, and meta-cumulative analyses were performed. All essential data were extracted using a standardized data extraction format, and the JBI quality appraisal checklist was used to assess the quality of studies. Egger’s test and Begg’s test were used in order to detect the publication bias. In the present systematic review and meta-analysis, 6,587,298 births in twenty-seven studies were included. The pooled birth prevalence of spina bifida in Africa was 0.13% with a range between 0.12% and 0.14%. In Africa, the highest burden of spina bifida was detected in Algeria (0.43%), Ethiopia (0.32%), Tanzania (0.26%), Cameron (0.12%), Egypt (0.10%), and South Africa (0.10%). The lowest burden of spina bifida was detected in Libya (0.006%) and Tunisia (0.009%). The high birth prevalence of spina bifida was detected in Africa. There was a significant variation in the prevalence of spina bifida among study countries in Africa. The authors recommend that special awareness creation with the help of health education intervention should be provided for mothers to focus on prevention in order to reduce the burden of spina bifida.

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