Liver gene regulatory networks: Contributing factors to nonalcoholic fatty liver disease

2020 ◽  
Vol 12 (3) ◽  
pp. e1480
Author(s):  
Inês Cebola
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Gene Regulatory Networks ◽  
Fatty Liver Disease ◽  
Regulatory Networks ◽  
Contributing Factors ◽  
Nonalcoholic Fatty Liver ◽  
Gene Regulatory ◽  
Liver Gene

scholarly journals The interplay of microRNAs and transcription factors in autophagy regulation in nonalcoholic fatty liver disease

2021 ◽  
Author(s):  
Yumi Kim ◽  
Da-Hye Lee ◽  
So-Hyun Park ◽  
Tae-Il Jeon ◽  
Chang Hwa Jung
Keyword(s):  
Transcription Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Posttranscriptional Regulation ◽  
Fatty Liver Disease ◽  
Regulatory Networks ◽  
Nonalcoholic Fatty Liver ◽  
Autophagy Pathway ◽  
Cytoplasmic Processes

AbstractThe autophagy-lysosomal degradation system has an important role in maintaining liver homeostasis by removing unnecessary intracellular components. Impaired autophagy has been linked to nonalcoholic fatty liver disease (NAFLD), which includes hepatitis, steatosis, fibrosis, and cirrhosis. Thus, gaining an understanding of the mechanisms that regulate autophagy and how autophagy contributes to the development and progression of NAFLD has become the focus of recent studies. Autophagy regulation has been thought to be primarily regulated by cytoplasmic processes; however, recent studies have shown that microRNAs (miRNAs) and transcription factors (TFs) also act as key regulators of autophagy by targeting autophagy-related genes. In this review, we summarize the miRNAs and TFs that regulate the autophagy pathway in NAFLD. We further focus on the transcriptional and posttranscriptional regulation of autophagy and discuss the complex regulatory networks involving these regulators in autophagy. Finally, we highlight the potential of targeting miRNAs and TFs involved in the regulation of autophagy for the treatment of NAFLD.

Nonalcoholic Fatty Liver Disease progresses to HCC in the absence of apparent Cirrhosis

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
J Ertle ◽  
A Dechêne ◽  
JP Sowa ◽  
V Penndorf ◽  
K Herzer ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

Enhanced liver fibrosis (ELF) score accurately detects advanced fibrosis in nonalcoholic fatty liver disease (NAFLD)

2018 ◽  
Author(s):  
K Staufer ◽  
R Marculescu ◽  
B Obermayer-Pietsch ◽  
J Stift ◽  
C Lackner ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Advanced Fibrosis ◽  
Nonalcoholic Fatty Liver

A pilot study of fenofibrate in hyperlipidemic pts with nonalcoholic fatty liver disease (NAFLD)

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
I Nagy ◽  
T Korom ◽  
A Pálvölgyi ◽  
J Lonovics
Keyword(s):  
Liver Disease ◽  
Pilot Study ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver
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