HLA Class II Polymorphism Contributes to Specify Desmoglein Derived Peptides in Pemphigus Vulgaris and Pemphigus Foliaceus

2000 ◽  
Vol 15 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Pascale Loiseau ◽  
Laurence Lecleach ◽  
Catherine Prost ◽  
Virginia Lepage ◽  
Marc Busson ◽  
...  
Keyword(s):  
Pemphigus Vulgaris ◽  
Class Ii ◽  
Hla Class Ii ◽  
Pemphigus Foliaceus

scholarly journals HLA-DRB1 and DQB1 genetic susceptibility to pemphigus vulgaris and pemphigus foliaceus in Vietnamese patients

2021 ◽  
Author(s):  
The Bich Thanh Vuong ◽  
Duc Minh Do ◽  
Phuc Thinh Ong ◽  
Thai Van Thanh Le
Keyword(s):  
Clinical Manifestations ◽  
Pemphigus Vulgaris ◽  
Class Ii ◽  
Hla Class Ii ◽  
Control Group ◽  
Direct Immunofluorescence ◽  
Pemphigus Foliaceus ◽  
High Morbidity ◽  
Increased Risk ◽  
Life Threatening

Background: Pemphigus is a group of rare, life-threatening bullous autoimmune diseases that affect the skin and mucous membranes and are associated with high morbidity and morbidity. HLA class II genes, particularly HLA-DRB1 and HLA-DQB1, play roles in pemphigus. Objectives: To investigate the susceptibility of HLA class II DRB1 and DQB1 alleles in Vietnamese patients with pemphigus vulgaris (PV) or pemphigus foliaceus (PF). Methods: The study enrolled 31 participants (22 with PV, 9 with PF) with diagnoses confirmed by clinical manifestations, histopathology, and direct immunofluorescence from November 2019 to June 2020. The HLA polymorphisms were determined by Sanger sequencing. The HLA-DRB1 and HLA-DQB1 profiles of the 101 healthy individuals in the control group have been published previously. Results: The frequencies of HLA-DRB1*14, DRB1*13:07, DRB1*04:04, DRB1*03:02, DQB1*02:02, and DQB1*05:03 were significantly higher, whereas those of DRB1*09:01, DRB1*12:02, DQB1*03:03, DQB1*05:01, and DQB1*06:01 were significantly lower, in the PV group than in the controls. The frequencies of DRB1*14:54, DRB1*13:07, and HLA-DQB1*03:02 were significantly higher in the PF group than in the controls. Conclusions: Alleles HLA-DRB1*14:54, DRB1*14:04, DRB1*14:03, DRB1*14:01, DRB1*14:12, DRB1*13:07, DRB1*04:04, DRB1*03:02, DQB1*02:02, and DQB1*05:03 were associated with an increased risk of PV, whereas alleles DRB1*09:01, DRB1*12:02, DQB1*03:03, DQB1*05:01, and DQB1*06:01 might protect against PV. In PF, DRB1*14:54, DRB1*13:07, and HLADQB1* 03:02 are promising susceptibility alleles.

Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region

2016 ◽  
Vol 72 ◽  
pp. 19-24 ◽  
Author(s):  
Maria José Franco Brochado ◽  
Daniela Francisca Nascimento ◽  
Wagner Campos ◽  
Neifi Hassan Saloum Deghaide ◽  
Eduardo Antonio Donadi ◽  
...  
Keyword(s):  
Hla Class I ◽  
Pemphigus Vulgaris ◽  
Class Ii ◽  
Class I ◽  
Pemphigus Foliaceus

HLA Class II Allelic Variation and Susceptibility to Pemphigus Vulgaris

1989 ◽  
pp. 429-432
Author(s):  
Stephen J. Scharf ◽  
Adam Friedmann ◽  
Chaim Brautbar ◽  
Fanny Szafer ◽  
Lawrence Steinman ◽  
...  
Keyword(s):  
Allelic Variation ◽  
Pemphigus Vulgaris ◽  
Class Ii ◽  
Hla Class Ii

scholarly journals A Truncated Alternative Spliced Isoform of Human Desmoglein 1 Contains a Specific T Cell Epitope Binding to the Pemphigus Foliaceus-Associated HLA Class II DRβ1*0102 Molecule

2006 ◽  
Vol 177 (9) ◽  
pp. 6517-6526 ◽  
Author(s):  
Hugo Mouquet ◽  
Sandrine Farci ◽  
Pascal Joly ◽  
Bernard Maillère ◽  
Jonathan Leblond ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Epitope ◽  
Class Ii ◽  
Hla Class Ii ◽  
Pemphigus Foliaceus ◽  
T Cell Epitope ◽  
Epitope Binding

scholarly journals Pemphigus Vulgaris in White Europeans Is Linked with HLA Class II Allele HLA DRB1*1454 but Not DRB1*1401

2010 ◽  
Vol 130 (1) ◽  
pp. 311-314 ◽  
Author(s):  
Monika Saha ◽  
Karen Harman ◽  
Neil J. Mortimer ◽  
Valentina Binda ◽  
Martin M. Black ◽  
...  
Keyword(s):  
Pemphigus Vulgaris ◽  
Class Ii ◽  
Hla Class Ii

Polymorphisms of HLA class II genes in Japanese patients with pemphigus vulgaris

1998 ◽  
Vol 52 (1) ◽  
pp. 74-77 ◽  
Author(s):  
Y. Yamashina ◽  
S. Miyagawa ◽  
T. Kawatsu ◽  
T. Iida ◽  
I. Higashimine ◽  
...  
Keyword(s):  
Pemphigus Vulgaris ◽  
Japanese Patients ◽  
Class Ii ◽  
Hla Class Ii

scholarly journals Epistasis between DSG1 and HLA class II genes in pemphigus foliaceus

2002 ◽  
Vol 3 (4) ◽  
pp. 205-210 ◽  
Author(s):  
P Martel ◽  
D Gilbert ◽  
M Busson ◽  
P Loiseau ◽  
V Lepage ◽  
...  
Keyword(s):  
Class Ii ◽  
Hla Class Ii ◽  
Pemphigus Foliaceus

scholarly journals Common Denominators in the Immunobiology of IgG4 Autoimmune Diseases: What Do Glomerulonephritis, Pemphigus Vulgaris, Myasthenia Gravis, Thrombotic Thrombocytopenic Purpura and Autoimmune Encephalitis Have in Common?

2021 ◽  
Vol 11 ◽  
Author(s):  
Inga Koneczny ◽  
Vuslat Yilmaz ◽  
Konstantinos Lazaridis ◽  
John Tzartos ◽  
Tobias L. Lenz ◽  
...  
Keyword(s):  
T Cells ◽  
Nervous System ◽  
Autoimmune Diseases ◽  
Myasthenia Gravis ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Autoimmune Encephalitis ◽  
Pemphigus Vulgaris ◽  
Class Ii ◽  
Hla Class Ii ◽  
Thrombocytopenic Purpura

IgG4 autoimmune diseases (IgG4-AID) are an emerging group of autoimmune diseases that are caused by pathogenic autoantibodies of the IgG4 subclass. It has only recently been appreciated, that members of this group share relevant immunobiological and therapeutic aspects even though different antigens, tissues and organs are affected: glomerulonephritis (kidney), pemphigus vulgaris (skin), thrombotic thrombocytopenic purpura (hematologic system) muscle-specific kinase (MuSK) in myasthenia gravis (peripheral nervous system) and autoimmune encephalitis (central nervous system) to give some examples. In all these diseases, patients’ IgG4 subclass autoantibodies block protein-protein interactions instead of causing complement mediated tissue injury, patients respond favorably to rituximab and share a genetic predisposition: at least five HLA class II genes have been reported in individual studies to be associated with several different IgG4-AID. This suggests a role for the HLA class II region and specifically the DRβ1 chain for aberrant priming of autoreactive T-cells toward a chronic immune response skewed toward the production of IgG4 subclass autoantibodies. The aim of this review is to provide an update on findings arguing for a common pathogenic mechanism in IgG4-AID in general and to provide hypotheses about the role of distinct HLA haplotypes, T-cells and cytokines in IgG4-AID.

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