Osmotic Pressure, Small-Angle X-Ray, and Dynamic Light Scattering Studies of Human Serum Albumin in Aqueous Solutions

2001 ◽  
Vol 239 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Jurij Reščič ◽  
Vojko Vlachy ◽  
Andrej Jamnik ◽  
Otto Glatter
Keyword(s):  
Light Scattering ◽  
Human Serum Albumin ◽  
Dynamic Light Scattering ◽  
Serum Albumin ◽  
Aqueous Solutions ◽  
Human Serum ◽  
Osmotic Pressure ◽  
Small Angle ◽  
X Ray

Human Serum Albumin Unfolding: A Small-Angle X-ray Scattering and Light Scattering Study

2008 ◽  
Vol 112 (48) ◽  
pp. 15460-15469 ◽  
Author(s):  
Luciano Galantini ◽  
Claudia Leggio ◽  
Nicolae Viorel Pavel
Keyword(s):  
Light Scattering ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Small Angle ◽  
X Ray ◽  
X Ray Scattering ◽  
Scattering Study ◽  
Ray Scattering

scholarly journals Pearl-necklace assembly of human serum albumin with the poly(acrylic acid) polyelectrolyte investigated using small angle X-ray scattering (SAXS)

Soft Matter ◽  
2020 ◽  
Vol 16 (43) ◽  
pp. 9964-9974
Author(s):  
Charaf E. Merzougui ◽  
Pierre Roblin ◽  
Pierre Aimar ◽  
Antoine Venault ◽  
Yung Chang ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Acrylic Acid ◽  
Serum Albumin ◽  
Human Serum ◽  
Small Angle ◽  
X Ray ◽  
X Ray Scattering ◽  
Comprehensive Study ◽  
Poly Acrylic Acid ◽  
Ray Scattering

In this comprehensive study, the interaction of human serum albumin (HSA) with poly(acrylic acid) (PAA) was explored using small angle X-ray scattering (SAXS) combined with chromatography.

Sodium dodecyl sulfate (SDS) effect on the thermal stability of oxy-HbGp: Dynamic light scattering (DLS) and small angle X-ray scattering (SAXS) studies

2013 ◽  
Vol 111 ◽  
pp. 561-570 ◽  
Author(s):  
José Wilson P. Carvalho ◽  
Fernanda Rosa Alves ◽  
Tatiana Batista ◽  
Francisco Adriano O. Carvalho ◽  
Patrícia S. Santiago ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Light Scattering ◽  
Sodium Dodecyl Sulfate ◽  
Dynamic Light Scattering ◽  
Small Angle ◽  
Sodium Dodecyl ◽  
X Ray ◽  
X Ray Scattering ◽  
Dodecyl Sulfate ◽  
Thermal Stability Of

scholarly journals Use of dynamic light scattering and small-angle X-ray scattering to characterize new surfactants in solution conditions for membrane-protein crystallization

2015 ◽  
Vol 71 (7) ◽  
pp. 838-846 ◽  
Author(s):  
Mohamed Dahani ◽  
Laurie-Anne Barret ◽  
Simon Raynal ◽  
Colette Jungas ◽  
Pétra Pernot ◽  
...  
Keyword(s):  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Membrane Protein ◽  
Small Angle ◽  
Protein Crystallization ◽  
X Ray ◽  
X Ray Scattering ◽  
Membrane Protein Crystallization ◽  
Surfactant Phase ◽  
Ray Scattering

The structural and interactive properties of two novel hemifluorinated surfactants, F2H9-β-M and F4H5-β-M, the syntheses of which were based on the structure and hydrophobicity of the well known dodecyl-β-maltoside (DD-β-M), are described. The shape of their micellar assemblies was characterized by small-angle X-ray scattering and their intermicellar interactions in crystallizing conditions were measured by dynamic light scattering. Such information is essential for surfactant phase-diagram determination and membrane-protein crystallization.

scholarly journals In Silico Prediction of Interactions between Site II on Human Serum Albumin and Profen Drugs

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Hideto Isogai ◽  
Noriaki Hirayama
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Sites ◽  
Binding Mode ◽  
X Ray ◽  
Docking Simulations ◽  
X Ray Crystallography ◽  
Inflammatory Drugs ◽  
Multiple Template

Since binding of a drug molecule to human serum albumin (HSA) significantly affects the pharmacokinetics of the drug, it is highly desirable to predict the binding affinity of the drug. Profen drugs are a widely used class of nonsteroidal anti-inflammatory drugs and it has been reported that several members of the profen class specifically bind to one of the main binding sites named site II. The actual binding mode of only ibuprofen has been directly confirmed by X-ray crystallography. Therefore, it is of interest whether other profen drugs are site II binders. Docking simulations using multiple template structures of HSA from three crystal structures of complexes between drugs and HSA have demonstrated that most of the currently available profen drugs should be site II binders.

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