Tissue Tumor Necrosis Factor mRNA Expression Following Cecal Ligation and Puncture or Intraperitoneal Injection of Endotoxin

1994 ◽  
Vol 56 (6) ◽  
pp. 549-555 ◽  
Author(s):  
Dimitri J. Hadjiminas ◽  
Kelly M. McMasters ◽  
James C. Peyton ◽  
William G. Cheadle
Keyword(s):  
Tumor Necrosis Factor ◽  
Mrna Expression ◽  
Intraperitoneal Injection ◽  
Tumor Necrosis ◽  
Cecal Ligation ◽  
Cecal Ligation And Puncture ◽  
Tissue Tumor ◽  
Tumor Necrosis Factor Mrna ◽  
Necrosis Factor

scholarly journals A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice

2019 ◽  
Vol 10 ◽  
Author(s):  
Jolien Vandewalle ◽  
Sophie Steeland ◽  
Sara Van Ryckeghem ◽  
Melanie Eggermont ◽  
Elien Van Wonterghem ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Cecal Ligation ◽  
Tumor Necrosis Factor Receptor ◽  
Cecal Ligation And Puncture ◽  
Tissue Specific ◽  
Specific Tumor ◽  
Deficient Mice ◽  
Necrosis Factor

Cecal Ligation and Puncture as a Model of Sepsis in the Rat: Influence of the Puncture Size on Mortality, Bacteremia, Endotoxemia and Tumor Necrosis Factor Alpha Levels

2001 ◽  
Vol 33 (2) ◽  
pp. 77-79 ◽  
Author(s):  
E. Otero-Antón ◽  
A. González-Quintela ◽  
A. López-Soto ◽  
S. López-Ben ◽  
J. Llovo ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Cecal Ligation ◽  
Cecal Ligation And Puncture ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Effect of training intensity on subcutaneous adipose leptin, adiponectin, interleukin 6, and tumor necrosis factor mRNA expression in middle‐aged women

2008 ◽  
Vol 22 (S2) ◽  
pp. 118-118 ◽  
Author(s):  
Soo‐hyun Park ◽  
Tae‐Kyung Han ◽  
Eue‐Soo Ann ◽  
Eun‐Sun Yoon ◽  
Byungroh Kim ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Mrna Expression ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Training Intensity ◽  
Middle Aged ◽  
Tumor Necrosis Factor Mrna ◽  
Subcutaneous Adipose ◽  
Necrosis Factor

Effect of TIPE1 on Immune Function of Dendritic Cells and Its Signaling Pathway in Septic Mice

2019 ◽  
Vol 220 (4) ◽  
pp. 699-709 ◽  
Author(s):  
Ying-yi Luan ◽  
Lei Zhang ◽  
Fu-jun Zhu ◽  
Ning Dong ◽  
Jiang-yang Lu ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Cecal Ligation ◽  
Negative Regulation ◽  
Cecal Ligation And Puncture ◽  
Factor Α ◽  
Necrosis Factor ◽  
Dc Maturation

Abstract Dendritic cell (DC) dysfunction plays a pivotal role in sepsis-induced immunosuppression. Tumor necrosis factor α (TNF-α)–induced protein 8 like-1 (TIPE1), a new member of the tumor necrosis factor α–induced protein 8 family, may be related to cell death. The aim of the present study was to elucidate the effect of TIPE1 on the immune function of DCs and its regulatory mechanism via PD-L1/PD-1 signaling in mice. Sepsis was induced in adult C57BL/6 male mice via cecal ligation and puncture. In vitro, we found that expression of CD80, CD86, and major histocompatibility complex class II in DCs and levels of cytokines, including tumor necrosis factor α and interleukin 12p40, were elevated; similarly, T-cell proliferation and differentiation were promoted when the gene expressing TIPE1 was silenced. Next, we examined the in vivo role of TIPE1 in a cecal ligation and puncture animal model system. Flow cytometry of the immune functional status in DCs revealed negative regulation of TIPE1 on DC maturation, as well as activation. Moreover, changes in PD-L1/PD-1 levels confirmed the negative effect of TIPE1 in DCs. Collectively, we report that TIPE1 might exert negative regulation in sepsis, at least in part by inhibiting DC maturation and subsequent T-cell–mediated immunity via PD-L1/PD-1 signaling.

scholarly journals Blockade of CD137 Signaling Counteracts Polymicrobial Sepsis Induced by Cecal Ligation and Puncture

2009 ◽  
Vol 77 (9) ◽  
pp. 3932-3938 ◽  
Author(s):  
Quang-Tam Nguyen ◽  
Seong-A Ju ◽  
Sang-Min Park ◽  
Sang-Chul Lee ◽  
Hideo Yagita ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Cecal Ligation ◽  
Polymicrobial Sepsis ◽  
Infection Model ◽  
Bacterial Clearance ◽  
Cecal Ligation And Puncture ◽  
Gram Positive ◽  
Necrosis Factor Alpha ◽  
Necrosis Factor

ABSTRACTSepsis, a leading cause of death worldwide, involves proinflammatory responses and inefficient bacterial clearance. Previously, we have shown that CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, plays critical roles in eradicating infectiveListeria monocytogenes, a gram-positive bacterium, and that stimulation of CD137 protects mice from sepsis-induced death. In this study, we unexpectedly found that CD137 activation aggravated polymicrobial sepsis due to mixed gram-positive and gram-negative bacterial infection induced by cecal ligation and puncture (CLP). CD137-deficient (CD137−/−) mice showed significantly lower mortality than CD137-sufficient (CD137+/+) mice in the CLP model. Administration of an agonistic anti-CD137 monoclonal antibody (MAb) to CD137+/+mice decreased their survival in this infection model, while administration of a blocking anti-CD137 ligand MAb (TKS-1) to such mice increased their survival. CD137−/−mice and TKS-1-treated CD137+/+mice had lower levels of chemokines/proinflammatory cytokines (monocyte chemoattractant protein 1, interleukin-6 [IL-6], tumor necrosis factor alpha, IL-12) and an anti-inflammatory cytokine (IL-10), exhibited improved bacterial clearance in the peritoneum, liver, and blood, and had greater numbers of infiltrated peritoneal neutrophils and macrophages in the CLP model than control mice. Our data suggest that CD137 activation aggravates polymicrobial sepsis induced by CLP.

BLOCKADE OF TUMOR NECROSIS FACTOR REDUCES LIPOPOLYSACCHARIDE LETHALITY, BUT NOT THE LETHALITY OF CECAL LIGATION AND PUNCTURE

Shock ◽  
1995 ◽  
Vol 4 (2) ◽  
pp. 89-95 ◽  
Author(s):  
Daniel Remick ◽  
Prerana Manohar ◽  
Gerald Bolgos ◽  
Jorge Rodriguez ◽  
Lyle Moldawer ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Cecal Ligation ◽  
Cecal Ligation And Puncture ◽  
Necrosis Factor
Sign in / Sign up

Export Citation Format

Share Document