Circulating Endothelial Progenitor Cells Is Increasing in Human T Cell Lymphotropic Virus Type 1 (HTLV1) Asymptomatic Carriers

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 5474-5474
Author(s):  
Ana Luisa Langanke Pedroso Meireles ◽  
Dalton Chamone ◽  
Carla Rosa Teixeira Godoy ◽  
Juliana Pereira
Keyword(s):  
Endothelial Cells ◽  
T Cell ◽  
Growth Factor ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Virus Type ◽  
Control Group ◽  
Human T Cell

Abstract The role of angiogenesis in metastasis of solid tumors is well established, but not in hematologic malignancies. Marwan et al demonstrated that Human T Cell Lymphotropic Virus Type 1 (HTLV1) transformed T cells secrete vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and induce angiogenesis in vitro. Adult T-cell leukemia-lymphoma (ATL) leukemic cells produce VEGF and bFGF proteins. Therefore, the role of angiogenesis in ATL development is under investigation. We interested whether endothelial progenitor cells (EPCs) and mature endothelial cells (ECs) contribute to tumor angiogenesis in ATL Thought, this cross-sectional study aimed at quantifying circulating endothelial cells in the blood of HTLV1 asymptomatic carriers in comparison to healthy individuals by flow cytometry. A sample of 30 HTLV1 carrier age and sex matched has been compared to the control group. We demonstrated that the EPCs values were greater in the asymptomatic HTLV1 carrier (median 0.8288 cells/mm3) rather than to the control group (median 0.4905 cells/mm3) (p = 0.035). We identified other pathway of the angiogenesis in HTLV1 carriers. However, others studies are necessary to confirm the role of EPCs in the ATL pathogenesis.

scholarly journals The Role of ITCH Protein in Human T-cell Leukemia Virus Type 1 Release

2011 ◽  
Vol 286 (36) ◽  
pp. 31092-31104 ◽  
Author(s):  
Batsukh Dorjbal ◽  
David Derse ◽  
Patricia Lloyd ◽  
Ferri Soheilian ◽  
Kunio Nagashima ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus

scholarly journals Increased Levels of Circulating Endothelial Progenitor Cells in Human T-cell Lymphotropic Virus Type I Carriers

2011 ◽  
Vol 42 (1) ◽  
pp. 34-37
Author(s):  
Ana Luisa L. Pedroso Meireles ◽  
Abrahão Elias Hallack Neto ◽  
Renata de Oliveira Costa ◽  
Juliana Pereira
Keyword(s):  
T Cell ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Virus Type ◽  
Type I ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells ◽  
Human T Cell

scholarly journals Induction of Cell Cycle Arrest by Human T-Cell Lymphotropic Virus Type 1 Tax in Hematopoietic Progenitor (CD34+) Cells: Modulation of p21cip1/waf1 and p27kip1 Expression

2005 ◽  
Vol 79 (22) ◽  
pp. 14069-14078 ◽  
Author(s):  
Adam Tripp ◽  
Prabal Banerjee ◽  
Michelle Sieburg ◽  
Vicente Planelles ◽  
Fengzhi Li ◽  
...  
Keyword(s):  
Cell Cycle ◽  
T Cell ◽  
Cell Cycle Arrest ◽  
Progenitor Cells ◽  
Virus Type ◽  
Hematopoietic Progenitor Cells ◽  
Hematopoietic Progenitor ◽  
Cycle Arrest ◽  
Human T Cell

ABSTRACT Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia, an aggressive CD4+ malignancy. Although HTLV-2 is highly homologous to HTLV-1, infection with HTLV-2 has not been associated with lymphoproliferative disorders. Lentivirus-mediated transduction of CD34+ cells with HTLV-1 Tax (Tax1) induced G0/G1 cell cycle arrest and resulted in the concomitant suppression of multilineage hematopoiesis in vitro. Tax1 induced transcriptional upregulation of the cdk inhibitors p21cip1/waf1 (p21) and p27kip1 (p27), and marked suppression of hematopoiesis in immature (CD34+/CD38−) hematopoietic progenitor cells in comparison to CD34+/CD38+ cells. HTLV-1 infection of CD34+ cells also induced p21 and p27 expression. Tax1 also protected CD34+ cells from serum withdrawal-mediated apoptosis. In contrast, HTLV-2 Tax (Tax2) did not detectably alter p21 or p27 gene expression, failed to induce cell cycle arrest, failed to suppress hematopoiesis in CD34+ cells, and did not protect cells from programmed cell death. A Tax2/Tax1 chimera encoding the C-terminal 53 amino acids of Tax1 fused to Tax2 (Tax221) displayed a phenotype in CD34+ cells similar to that of Tax1, suggesting that unique domains encoded within the C terminus of Tax1 may account for the phenotypes displayed in human hematopoietic progenitor cells. These remarkable differences in the activities of Tax1 and Tax2 in CD34+ hematopoietic progenitor cells may underlie the sharp differences observed in the pathogenesis resulting from infection with HTLV-1 and HTLV-2.

scholarly journals Immune Response against the Exp-1 Protein of Plasmodium falciparum Results in Antibodies That Cross-React with Human T-Cell Lymphotropic Virus Type 1 Proteins

1998 ◽  
Vol 5 (5) ◽  
pp. 721-724 ◽  
Author(s):  
Kevin R. Porter ◽  
Joao Aguiar ◽  
Allen Richards ◽  
B. Sandjaya ◽  
H. Ignatias ◽  
...  
Keyword(s):  
Immune Response ◽  
Plasmodium Falciparum ◽  
T Cell ◽  
Western Blot ◽  
Virus Type ◽  
False Positive ◽  
Type I ◽  
Human T Cell

ABSTRACT To examine the role of the Plasmodium falciparum Exp-1 blood-stage protein in producing antibodies that cross-react with human T-cell lymphotropic virus type I (HTLV-I) proteins, we studied sera from Indonesian volunteers who seroconverted to malaria after transmigrating to an area where malaria is hyperendemic. Samples from Philippine volunteers, that were used in a prior study that examined malaria antibodies that cross-react with HTLV-I proteins, were also used. Eighty-three percent of the Indonesian transmigrants developed antibodies against the malaria Exp-1 protein by 6 months postmigration. Of these malaria seroconverters, 27% developed false-positive HTLV-I enzyme immunoassay (EIA) immunoreactivity, as indicated by indeterminate HTLV-I Western blot banding patterns. Five of the six Philippine samples tested were HTLV-I EIA false positive and Western blot indeterminate. When a recombinant Exp-1 protein was used in blocking experiments, the HTLV-I Western blot immunoreactivity of sera from both groups was either completely eliminated or greatly reduced. No effect on the Western blot immunoreactivity of truly HTLV-I-positive sera was seen. To determine if immunization with the recombinant Exp-1 protein could elicit the production of HTLV-I antibodies, six mice were inoculated with the recombinant protein. Following administration of three 50-μg doses of the protein, four of the six mice developed antibodies that cross-reacted with HTLV-I proteins on Western blot. These results indicate that the immune response against the malaria Exp-1 protein may result in HTLV-I-cross-reacting antibodies that can lead to false-positive EIA and indeterminant Western blotting results.

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