Chromosomal deletions and tumor suppressor genes in prostate cancer

2006 ◽  
pp. 37-57
Author(s):  
Jin-Tang Dong
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Suppressor Genes ◽  
Chromosomal Deletions

Aneuploidy of Chromosome 9 and the Tumor Suppressor Genes p16INK4 and p15INK4B Detected by in situ Hybridization in Locally Advanced Prostate Cancer

2000 ◽  
Vol 38 (4) ◽  
pp. 475-482 ◽  
Author(s):  
Birgit Heidenreich ◽  
Axel Heidenreich ◽  
Andreas Sesterhenn ◽  
Shiv Srivastava ◽  
Judd W. Moul ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Situ Hybridization ◽  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Chromosome 9 ◽  
Locally Advanced Prostate Cancer ◽  
Suppressor Genes

Two putative tumor suppressor genes on chromosome arm 8p may play different roles in prostate cancer

2001 ◽  
Vol 124 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Kazuo Oba ◽  
Hideyasu Matsuyama ◽  
Satoru Yoshihiro ◽  
Fumio Kishi ◽  
Mutsuo Takahashi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Suppressor Genes ◽  
Putative Tumor Suppressor ◽  
Chromosome Arm

Molecular Pathogenesis of MDS

Hematology ◽  
2005 ◽  
Vol 2005 (1) ◽  
pp. 156-160 ◽  
Author(s):  
A. Thomas Look
Keyword(s):  
Tumor Suppressor ◽  
Progenitor Cells ◽  
Tumor Suppressors ◽  
Tumor Suppressor Genes ◽  
Molecular Mechanisms ◽  
Point Mutations ◽  
Suppressor Genes ◽  
Hematopoietic Stem ◽  
Chromosomal Deletions ◽  
Genes Encoding

Abstract Clonal disorders of hematopoiesis, such as myelodysplastic syndromes (MDS) and myeloproliferative diseases (MPD), affect both hematopoietic stem cells and progenitor cells within the erythroid, platelet and granulocytic lineages and can have devastating consequences in children and adults. The genetic features of these diseases often include clonal, nonrandom chromosomal deletions (e.g., 7q–, 5q–, 20q–, 6q–, 11q– and 13q–) that appear to inactivate tumor suppressor genes required for the normal development of myeloid cells (reviewed in Bench1 and Fenaux2). These putative tumor suppressors have proved to be much more difficult to identify than oncogenes activated by chromosomal translocations, the other major class of chromosomal lesions in MDS and MPD.3 Although MDS and MPD are almost certainly caused by mutations in stem/progenitor cells,4 the role of inactivated tumor suppressor genes in this process remains poorly understood. In a small portion of myeloid diseases, mutations have been identified in genes encoding factors known to be required for normal hematopoiesis, such as PU.1, RUNX1, CTNNA1 (α-catenin) and c/EBPα, and implicating these genes as tumor suppressors.5–7 Nonetheless, the identities of most deletion-associated tumor suppressors in these diseases remains elusive, despite complete sequencing of the human genome. The deleted regions detected by cytogenetic methods are generally very large, containing many hundreds of genes, thus making it hard to locate the critical affected gene or genes. It is also unclear whether dysfunctional myelopoiesis results from haploinsufficiency, associated with the deletion of one allele, or from homozygous inactivation due to additional point mutations or microdeletions of the retained wild-type allele. In general MDS have proved surprisingly resistant to conventional treatments. Targeted therapeutic advances in MDS will likely depend on a full comprehension of underlying molecular mechanisms, in particular the tumor suppressor genes lost through clonal, nonrandom chromosomal deletions, such as the 7q– and (del)5q.

scholarly journals Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent

The Prostate ◽  
2012 ◽  
Vol 72 (16) ◽  
pp. 1767-1778 ◽  
Author(s):  
Hsiang-Yu Lin ◽  
Yi-Chiu Kuo ◽  
Yu-I Weng ◽  
I-Lu Lai ◽  
Tim H.-M. Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Genes ◽  
Energy Restriction ◽  
Prostate Cancer Cells ◽  
Suppressor Genes

scholarly journals Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer

2009 ◽  
Vol 77 (1) ◽  
pp. 103-111 ◽  
Author(s):  
Suzana S. Couto ◽  
Mei Cao ◽  
Paulo C. Duarte ◽  
Whitney Banach-Petrosky ◽  
Shunyou Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Mouse Model ◽  
Tumor Suppressor Genes ◽  
Suppressor Genes
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