Nonviral Delivery of Cancer Genetic Vaccines

2005 ◽  
pp. 93-118 ◽  
Author(s):  
Steven R. Little ◽  
Robert Langer
Keyword(s):  
Cancer Genetic ◽  
Nonviral Delivery

Cancer Genetic Counseling by Humanoid Robot

2020 ◽  
Author(s):  
Shuo Zhou ◽  
Prasanth Murali ◽  
Meghan Underhill-Blazey ◽  
Timothy Bickmore
Keyword(s):  
Genetic Counseling ◽  
Humanoid Robot ◽  
Cancer Genetic Counseling ◽  
Cancer Genetic

scholarly journals Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 821
Author(s):  
Wanglong Qiu ◽  
Chia-Yu Kuo ◽  
Yu Tian ◽  
Gloria H. Su
Keyword(s):  
Pancreatic Cancer ◽  
Signaling Pathway ◽  
Critical Role ◽  
Genetic Mutations ◽  
Cancer Genetic ◽  
Dual Roles ◽  
Activin Signaling ◽  
Physiological Processes ◽  
Cancer Types ◽  
Related Proteins

Activin, a member of the TGF-β superfamily, is involved in many physiological processes, such as embryonic development and follicle development, as well as in multiple human diseases including cancer. Genetic mutations in the activin signaling pathway have been reported in many cancer types, indicating that activin signaling plays a critical role in tumorigenesis. Recent evidence reveals that activin signaling may function as a tumor-suppressor in tumor initiation, and a promoter in the later progression and metastasis of tumors. This article reviews many aspects of activin, including the signaling cascade of activin, activin-related proteins, and its role in tumorigenesis, particularly in pancreatic cancer development. The mechanisms regulating its dual roles in tumorigenesis remain to be elucidated. Further understanding of the activin signaling pathway may identify potential therapeutic targets for human cancers and other diseases.

scholarly journals Cancer genetic testing in marginalized groups during an era of evolving healthcare reform

2021 ◽  
Vol 28 ◽  
pp. 100275
Author(s):  
Stephen M. Modell ◽  
Caitlin G. Allen ◽  
Amy Ponte ◽  
Gail Marcus
Keyword(s):  
Genetic Testing ◽  
Healthcare Reform ◽  
Cancer Genetic ◽  
Marginalized Groups

scholarly journals State of the art on lung organoids in mammals

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Fabienne Archer ◽  
Alexandra Bobet-Erny ◽  
Maryline Gomes
Keyword(s):  
Lung Development ◽  
One Health ◽  
State Of The Art ◽  
Animal Health ◽  
In Vitro Models ◽  
Cancer Genetic ◽  
3 Dimensional ◽  
The One ◽  
Species Specific

AbstractThe number and severity of diseases affecting lung development and adult respiratory function have stimulated great interest in developing new in vitro models to study lung in different species. Recent breakthroughs in 3-dimensional (3D) organoid cultures have led to new physiological in vitro models that better mimic the lung than conventional 2D cultures. Lung organoids simulate multiple aspects of the real organ, making them promising and useful models for studying organ development, function and disease (infection, cancer, genetic disease). Due to their dynamics in culture, they can serve as a sustainable source of functional cells (biobanking) and be manipulated genetically. Given the differences between species regarding developmental kinetics, the maturation of the lung at birth, the distribution of the different cell populations along the respiratory tract and species barriers for infectious diseases, there is a need for species-specific lung models capable of mimicking mammal lungs as they are of great interest for animal health and production, following the One Health approach. This paper reviews the latest developments in the growing field of lung organoids.

scholarly journals Association between breast cancer genetic susceptibility variants and terminal duct lobular unit involution of the breast

2016 ◽  
Vol 140 (4) ◽  
pp. 825-832 ◽  
Author(s):  
Clara Bodelon ◽  
Hannah Oh ◽  
Nilanjan Chatterjee ◽  
Montserrat Garcia-Closas ◽  
Maya Palakal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Susceptibility ◽  
Cancer Genetic ◽  
Terminal Duct Lobular Unit

scholarly journals Percutaneous Nonviral Delivery of Hepatocyte Growth Factor in an Osteotomy Gap Promotes Bone Repair in Rabbits: A Preliminary Study

2008 ◽  
Vol 466 (12) ◽  
pp. 2962-2972 ◽  
Author(s):  
Hidenori Matsubara ◽  
Hiroyuki Tsuchiya ◽  
Koji Watanabe ◽  
Akihiko Takeuchi ◽  
Katsuro Tomita
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Bone Repair ◽  
Nonviral Delivery ◽  
Preliminary Study ◽  
Hepatocyte Growth
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