The Cancer Risk from Low Level Radiation

2011 ◽  
pp. 61-79 ◽  
Author(s):  
Bernard L. Cohen
Keyword(s):  
Cancer Risk ◽  
Low Level

scholarly journals The Cancer Risk from Low-Level Radiation

1981 ◽  
Vol 37 (4) ◽  
pp. 471
Author(s):  
LC Bernard
Keyword(s):  
Cancer Risk ◽  
Low Level

scholarly journals Low level exposure to asbestos: is there a cancer risk?

1988 ◽  
Vol 45 (8) ◽  
pp. 505-508
Author(s):  
J M Davis ◽  
J C McDonald
Keyword(s):  
Cancer Risk ◽  
Low Level

Cancer Risk of Low-Level Exposure

Science ◽  
1996 ◽  
Vol 271 (5257) ◽  
pp. 1821-1822 ◽  
Author(s):  
M. Goldman
Keyword(s):  
Cancer Risk ◽  
Low Level

Facts and Controversies About Radiation Exposure, Part 2: Low-Level Exposures and Cancer Risk

2007 ◽  
Vol 4 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Jadwiga (Jodi) Strzelczyk ◽  
John Damilakis ◽  
M. Victoria Marx ◽  
Katarzyna J. Macura
Keyword(s):  
Cancer Risk ◽  
Radiation Exposure ◽  
Low Level

Low-level arsenic exposure is associated with bladder cancer risk and cigarette smoking: a case–control study among men in Tunisia

2012 ◽  
Vol 20 (6) ◽  
pp. 3923-3931 ◽  
Author(s):  
Molka Feki-Tounsi ◽  
Pablo Olmedo ◽  
Fernando Gil ◽  
Rim Khlifi ◽  
Mohamed-Nabil Mhiri ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Risk ◽  
Cigarette Smoking ◽  
Case Control Study ◽  
Arsenic Exposure ◽  
Case Control ◽  
Bladder Cancer Risk ◽  
Low Level ◽  
Control Study

Cancer Risk from Low-Level Radiation

2002 ◽  
Vol 179 (5) ◽  
pp. 1137-1143 ◽  
Author(s):  
Bernard L. Cohen
Keyword(s):  
Cancer Risk ◽  
Low Level

scholarly journals Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues

2018 ◽  
Vol 115 (6) ◽  
pp. 1328-1333 ◽  
Author(s):  
Satoshi Yamashita ◽  
Takayoshi Kishino ◽  
Takamasa Takahashi ◽  
Taichi Shimazu ◽  
Hadrien Charvat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cancer Risk ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Genetic Alterations ◽  
Marker Genes ◽  
Relative Importance ◽  
Epigenetic Alterations ◽  
Low Level ◽  
Normal Tissues

Genetic and epigenetic alterations are both involved in carcinogenesis, and their low-level accumulation in normal tissues constitutes cancer risk. However, their relative importance has never been examined, as measurement of low-level mutations has been difficult. Here, we measured low-level accumulations of genetic and epigenetic alterations in normal tissues with low, intermediate, and high cancer risk and analyzed their relative effects on cancer risk in the esophagus and stomach. Accumulation of genetic alterations, estimated as a frequency of rare base substitution mutations, significantly increased according to cancer risk in esophageal mucosae, but not in gastric mucosae. The mutation patterns reflected the exposure to lifestyle risk factors. In contrast, the accumulation of epigenetic alterations, measured as DNA methylation levels of marker genes, significantly increased according to cancer risk in both tissues. Patients with cancer (high-risk individuals) were precisely discriminated from healthy individuals with exposure to risk factors (intermediate-risk individuals) by a combination of alterations in the esophagus (odds ratio, 18.2; 95% confidence interval, 3.69–89.9) and by only epigenetic alterations in the stomach (odds ratio, 7.67; 95% confidence interval, 2.52–23.3). The relative importance of epigenetic alterations upon genetic alterations was 1.04 in the esophagus and 2.31 in the stomach. The differential impacts among tissues will be critically important for effective cancer prevention and precision cancer risk diagnosis.

The Cancer Risk From Low-level Radiation

1980 ◽  
Vol 39 (4) ◽  
pp. 659-678 ◽  
Author(s):  
Bernard L. Cohen
Keyword(s):  
Cancer Risk ◽  
Low Level

The Cancer Risk from Low Level Radiation

1981 ◽  
pp. 497-519
Author(s):  
Bernard L. Cohen
Keyword(s):  
Cancer Risk ◽  
Low Level
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