Light Signal Transduction Coupled with Reactive Oxygen Species in Neurospora crassa

2007 ◽  
pp. 315-321
Author(s):  
Kohji Hasunuma ◽  
Yusuke Yoshida ◽  
Bumkyu Lee
Keyword(s):  
Reactive Oxygen Species ◽  
Signal Transduction ◽  
Neurospora Crassa ◽  
Reactive Oxygen ◽  
Light Signal ◽  
Oxygen Species ◽  
Light Signal Transduction

scholarly journals Regulation of Vascular Calcification by Reactive Oxygen Species

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 963 ◽  
Author(s):  
Andrea Tóth ◽  
Enikő Balogh ◽  
Viktória Jeney
Keyword(s):  
Reactive Oxygen Species ◽  
Signal Transduction ◽  
Vascular Calcification ◽  
Reactive Oxygen ◽  
Experimental Models ◽  
Signal Transduction Pathways ◽  
Ros Production ◽  
Oxygen Species ◽  
Protective Mechanisms ◽  
Phenotype Switch

Vascular calcification is the deposition of hydroxyapatite crystals in the medial or intimal layers of arteries that is usually associated with other pathological conditions including but not limited to chronic kidney disease, atherosclerosis and diabetes. Calcification is an active, cell-regulated process involving the phenotype transition of vascular smooth muscle cells (VSMCs) from contractile to osteoblast/chondrocyte-like cells. Diverse triggers and signal transduction pathways have been identified behind vascular calcification. In this review, we focus on the role of reactive oxygen species (ROS) in the osteochondrogenic phenotype switch of VSMCs and subsequent calcification. Vascular calcification is associated with elevated ROS production. Excessive ROS contribute to the activation of certain osteochondrogenic signal transduction pathways, thereby accelerating osteochondrogenic transdifferentiation of VSMCs. Inhibition of ROS production and ROS scavengers and activation of endogenous protective mechanisms are promising therapeutic approaches in the prevention of osteochondrogenic transdifferentiation of VSMCs and subsequent vascular calcification. The present review discusses the formation and actions of excess ROS in different experimental models of calcification, and the potential of ROS-lowering strategies in the prevention of this deleterious condition.

Analysis of light signal transduction affecting morphogenesis of perithecia in Neurospora crassa

1997 ◽  
Vol 9 (1) ◽  
pp. 13-22
Author(s):  
Kohji HASUNUMA ◽  
Yasunobu OGURA ◽  
Kazushi ODA ◽  
Naoto YABE
Keyword(s):  
Signal Transduction ◽  
Neurospora Crassa ◽  
Light Signal ◽  
Light Signal Transduction
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