Adipose Tissue-Derived Stromal Cells for Wound Healing

2018 ◽  
pp. 133-149 ◽  
Author(s):  
Parisa Goodarzi ◽  
Sepideh Alavi-Moghadam ◽  
Masoumeh Sarvari ◽  
Akram Tayanloo Beik ◽  
Khadijeh Falahzadeh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adipose Tissue ◽  
Stromal Cells

scholarly journals Augmentation of Dermal Wound Healing by Adipose Tissue-Derived Stromal Cells (ASC)

2018 ◽  
Vol 5 (4) ◽  
pp. 91 ◽  
Author(s):  
Joris van Dongen ◽  
Martin Harmsen ◽  
Berend van der Lei ◽  
Hieronymus Stevens
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Adipose Tissue ◽  
Stromal Cells ◽  
Randomized Clinical Trials ◽  
Cell Types ◽  
Matrix Remodeling ◽  
Skin Wound Healing ◽  
Dermal Wound Healing ◽  
Dermal Wound

The skin is the largest organ of the human body and is the first line of defense against physical and biological damage. Thus, the skin is equipped to self-repair and regenerates after trauma. Skin regeneration after damage comprises a tightly spatial-temporally regulated process of wound healing that involves virtually all cell types in the skin. Wound healing features five partially overlapping stages: homeostasis, inflammation, proliferation, re-epithelization, and finally resolution or fibrosis. Dysreguled wound healing may resolve in dermal scarring. Adipose tissue is long known for its suppressive influence on dermal scarring. Cultured adipose tissue-derived stromal cells (ASCs) secrete a plethora of regenerative growth factors and immune mediators that influence processes during wound healing e.g., angiogenesis, modulation of inflammation and extracellular matrix remodeling. In clinical practice, ASCs are usually administered as part of fractionated adipose tissue i.e., as part of enzymatically isolated SVF (cellular SVF), mechanically isolated SVF (tissue SVF), or as lipograft. Enzymatic isolation of SVF obtained adipose tissue results in suspension of adipocyte-free cells (cSVF) that lack intact intercellular adhesions or connections to extracellular matrix (ECM). Mechanical isolation of SVF from adipose tissue destructs the parenchyma (adipocytes), which results in a tissue SVF (tSVF) with intact connections between cells, as well as matrix. To date, due to a lack of well-designed prospective randomized clinical trials, neither cSVF, tSVF, whole adipose tissue, or cultured ASCs can be indicated as the preferred preparation procedure prior to therapeutic administration. In this review, we present and discuss current literature regarding the different administration options to apply ASCs (i.e., cultured ASCs, cSVF, tSVF, and lipografting) to augment dermal wound healing, as well as the available indications for clinical efficacy.

scholarly journals Cell Therapy Based on Adipose Tissue-Derived Stromal Cells Promotes Physiological and Pathological Wound Healing

2009 ◽  
Vol 29 (4) ◽  
pp. 503-510 ◽  
Author(s):  
T.G. Ebrahimian ◽  
F. Pouzoulet ◽  
C. Squiban ◽  
V. Buard ◽  
M. André ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adipose Tissue ◽  
Cell Therapy ◽  
Stromal Cells

In vitro comparative study of human mesenchymal stromal cells from dermis and adipose tissue for application in skin wound healing

2019 ◽  
Vol 13 (5) ◽  
pp. 729-741 ◽  
Author(s):  
Helena Debiazi Zomer ◽  
Gisele Kristina dos Santos Varela ◽  
Priscilla Barros Delben ◽  
Diana Heck ◽  
Talita da Silva Jeremias ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adipose Tissue ◽  
Comparative Study ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Human Mesenchymal Stromal Cells

scholarly journals Stimulatory Effect of Autologous Adipose Tissue-Derived Stromal Cells in an Atelocollagen Matrix on Wound Healing in Diabetic db/db Mice

2011 ◽  
Author(s):  
M. Nambu ◽  
M. Ishihara ◽  
S. Kishimoto ◽  
S. Yanagibayashi ◽  
N. Yamamoto ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adipose Tissue ◽  
Stromal Cells

scholarly journals Enhanced Healing of Diabetic Wounds by Topical Administration of Adipose Tissue-Derived Stromal Cells Overexpressing Stromal-Derived Factor-1: Biodistribution and Engraftment Analysis by Bioluminescent Imaging

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Giuliana Di Rocco ◽  
Antonietta Gentile ◽  
Annalisa Antonini ◽  
Francesca Ceradini ◽  
Joseph C. Wu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adipose Tissue ◽  
Progenitor Cells ◽  
Stromal Cells ◽  
Topical Administration ◽  
Diabetic Patients ◽  
Bioluminescent Imaging ◽  
Major Health Problem ◽  
Wound Site ◽  
Cellular Recruitment

Chronic ulcers represent a major health problem in diabetic patients resulting in pain and discomfort. Conventional therapy does not guarantee adequate wound repair. In diabetes, impaired healing is partly due to poor endothelial progenitor cells mobilisation and homing, with altered levels of the chemokine stromal-derived factor-1 (SDF-1) at the wound site. Adipose tissue-associated stromal cells (AT-SCs) can provide an accessible source of progenitor cells secreting proangiogenic factors and differentiating into endothelial-like cells. We demonstrated that topical administration of AT-SCs genetically modifiedex vivoto overexpress SDF-1, promotes wound healing into diabetic mice. In particular, byin vivobioluminescent imaging analysis, we monitored biodistribution and survival after transplantation of luciferase-expressing cells. In conclusion, this study indicates the therapeutic potential of AT-SCs administration in wound healing, through cell differentiation, enhanced cellular recruitment at the wound site, and paracrine effects associated with local growth-factors production.

Accelerated Wound Healing in Healing-Impaired db/db Mice by Autologous Adipose Tissue-Derived Stromal Cells Combined With Atelocollagen Matrix

2009 ◽  
Vol 62 (3) ◽  
pp. 317-321 ◽  
Author(s):  
Masaki Nambu ◽  
Satoko Kishimoto ◽  
Shingo Nakamura ◽  
Hiroshi Mizuno ◽  
Satoshi Yanagibayashi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adipose Tissue ◽  
Stromal Cells

Relevance of Thoracic Adipose Tissue in Wound Healing Disorder of Diabetic Patients

2015 ◽  
Vol 63 (S 01) ◽  
Author(s):  
J. Andres ◽  
C. Dittfeld ◽  
A. Jannasch ◽  
K. Plötze ◽  
T. Waldow ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adipose Tissue ◽  
Diabetic Patients
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