The Horizon of Gene Therapy in Modern Medicine: Advances and Challenges

2019 ◽  
pp. 33-64 ◽  
Author(s):  
Babak Arjmand ◽  
Bagher Larijani ◽  
Motahareh Sheikh Hosseini ◽  
Moloud Payab ◽  
Kambiz Gilany ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Modern Medicine

scholarly journals Gene Therapy: A New Approach in Modern Medicine

2018 ◽  
Vol 5 (3) ◽  
pp. 106-117 ◽  
Author(s):  
Azam Yazdani ◽  
Zahra Alirezaie ◽  
Mohammad Javad Motamedi ◽  
Jafar Amani
Keyword(s):  
Gene Therapy ◽  
Modern Medicine ◽  
New Approach

Clinical experiences of gene therapy.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17561-e17561
Author(s):  
Longjiang Li
Keyword(s):  
Gene Therapy ◽  
Clinical Trials ◽  
Cancer Patients ◽  
Treatment Protocol ◽  
Modern Medicine ◽  
Therapeutic Effects ◽  
Clinical Experiences ◽  
Clinical Issues ◽  
Dosage Calculation ◽  
Promising Treatment

e17561 Background: Based on the theoretic and clinical development of modern medicine, gene therapy has been a promising treatment strategy for cancer and other patients. Methods: In the present paper, we reviewed the history and clinical experiences of gene therapy from the aspects of treatment protocol, administration cycle, dosage calculation and evaluation of therapeutic effects, in order to provide more information for the further development of this promising treatment. Results: Although the development of gene therapy has not gone smoothly since the beginning of the clinical trials, the results showed that this was a promising treatment for the cancer patients. There are still a lot of researches needed to be done to further solve the theoretic and clinical issues, and to improve the therapeutic effects. Conclusions: : In conclusion, although the development of gene therapy has not gone smoothly since the beginning of the clinical trials, the results showed that this was a promising treatment for the cancer patients. There are still a lot of researches needed to be done to further solve the theoretic and clinical issues, and to improve the therapeutic effects. But the future of the gene therapy will be bright, and it will become a new basic strategy to help more patients.

Drugs for gene therapy: features of usage in geriatrics and pediatrics

2020 ◽  
Vol 18 (3) ◽  
pp. 237-244
Author(s):  
Konstantin G. Gurevich ◽  
Yulya A. Sorokina ◽  
Alexander L. Urakov ◽  
Darya M. Gavrilova ◽  
Lyubov V. Lovtsova ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nucleic Acid ◽  
Modern Medicine ◽  
Mechanisms Of Action ◽  
Gene Engineering ◽  
Pharmaceutical Substance ◽  
Genetic Sequence ◽  
Existing Problems ◽  
Therapeutic Drugs ◽  
Definition Of

Advances in modern medicine and biotechnology allow specialists to adjust the patients proteome and metabolome. Gene engineering allows us to create drugs that affect the cause of the disease at the level of gene expression. Thus, not the links of pathogenesis or the symptom of the disease are subjected to correction, but the trigger itself, a defective gene that provokes a cascade of pathological processes. According to the definition of the State Pharmacopoeia, gene therapeutic drugs are drugs whose pharmaceutical substance is a recombinant nucleic acid or includes a recombinant nucleic acid that allows for the regulation, repair, replacement, addition or removal of a genetic sequence. The article reflects all available, developed and used in real clinical practice gene therapy drugs of russian and foreign production. The mechanisms of action, features of the use of these drugs in pediatric and geriatric practice, as well as existing problems and limitations of their use, including deontological issues, are noted.

Targeted delivery for neurodegenerative disorders using gene therapy vectors: Gen next therapeutic goals

2020 ◽  
Vol 20 ◽  
Author(s):  
Manisha Singh ◽  
Surinder P. Singh ◽  
Deepshikha Yadav ◽  
Mugdha Agarwal ◽  
Shriya Agarwal ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Targeted Delivery ◽  
Molecular Mechanisms ◽  
Muscular Atrophy ◽  
Treatment Options ◽  
Modern Medicine ◽  
Motor Neuron Diseases ◽  
Therapeutic Goals ◽  
Gene Therapy Vectors ◽  
Altered Gene

: The technique of gene therapy, ever since its advent nearly fifty years ago, has been utilized by scientists as a po-tential treatment option for various disorders. This review discusses some of the major neurodegenerative diseases (NDDs) like Alzheimer's disease (AD), Parkinson's disease (PD), Motor neuron diseases (MND), Spinal muscular atrophy (SMA), Huntington's disease (HD), Multiple sclerosis (MS) etc. and their underlying genetic mechanisms along with therole that gene therapy can play in combating them. The pathogenesis and the molecular mechanisms specifying the altered gene ex-pression of each of these NDDs has also been discussed in elaboration. The use of gene therapy vectors can prove to be an effective tool in the field of curative modern medicine for the generations to come. Therefore, consistent efforts and pro-gressive research towards its implementation can provide us with powerful treatment options for disease conditions that have so far been considered as incurable

scholarly journals Gene therapy: cornerstone of modern medicine in the new millennium?

Gene Therapy ◽  
2004 ◽  
Vol 11 (5) ◽  
pp. 427-428 ◽  
Author(s):  
Jenny Jacoby
Keyword(s):  
Gene Therapy ◽  
Modern Medicine ◽  
New Millennium

Global history and clinical experiences of gene therapy: A brief review.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17562-e17562
Author(s):  
Yi Li
Keyword(s):  
Gene Therapy ◽  
Clinical Trials ◽  
Cancer Patients ◽  
Treatment Protocol ◽  
Modern Medicine ◽  
Therapeutic Effects ◽  
Clinical Experiences ◽  
Clinical Issues ◽  
Dosage Calculation ◽  
Promising Treatment

e17562 Background: Based on the theoretic and clinical development of modern medicine, gene therapy has been a promising treatment strategy for cancer and other patients. Methods: In the present paper, we reviewed the history and clinical experiences of gene therapy from the aspects of treatment protocol, administration cycle, dosage calculation and evaluation of therapeutic effects, in order to provide more information for the further development of this promising treatment. Results: although the development of gene therapy has not gone smoothly since the beginning of the clinical trials, the results showed that this was a promising treatment for the cancer patients. There are still a lot of researches needed to be done to further solve the theoretic and clinical issues, and to improve the therapeutic effects. Conclusions: In conclusion, although the development of gene therapy has not gone smoothly since the beginning of the clinical trials, the results showed that this was a promising treatment for the cancer patients. There are still a lot of researches needed to be done to further solve the theoretic and clinical issues, and to improve the therapeutic effects. But the future of the gene therapy will be bright, and it will become a new basic strategy to help more patients.

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