Experimental Protocol of MSC Differentiation into Neural Lineage for Nerve Tissue Regeneration Using Polymeric Scaffolds

2019 ◽  
pp. 109-117 ◽  
Author(s):  
Roqia Ashraf ◽  
Hasham S. Sofi ◽  
Faheem A. Sheikh
Keyword(s):  
Tissue Regeneration ◽  
Nerve Tissue ◽  
Experimental Protocol ◽  
Neural Lineage ◽  
Polymeric Scaffolds ◽  
Msc Differentiation

Prospects of Natural Polymeric Scaffolds in Peripheral Nerve Tissue-Regeneration

2018 ◽  
pp. 501-525 ◽  
Author(s):  
Roqia Ashraf ◽  
Hasham S. Sofi ◽  
Mushtaq A. Beigh ◽  
Shafquat Majeed ◽  
Shabana Arjamand ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Tissue Regeneration ◽  
Nerve Tissue ◽  
Polymeric Scaffolds

Amniotic Stem Cell-Conditioned Media for the Treatment of Nerve and Muscle Pathology: A Systematic Review

2021 ◽  
Author(s):  
Chukwuweike Gwam ◽  
Ahmed Emara ◽  
Nequesha Mohamed ◽  
Noor Chughtai ◽  
Johannes Plate ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Tissue Regeneration ◽  
Cell Damage ◽  
Conditioned Media ◽  
Nerve Tissue ◽  
Muscle Pathology ◽  
Loss Of Function ◽  
Cell Based Therapy

Muscle and nerve tissue damage can elicit a significant loss of function and poses as a burden for patients and healthcare providers. Even for tissues, such as the peripheral nerve and skeletal muscle, that harbor significant regenerative capacity, innate regenerative processes often lead to less than optimal recovery and residual loss of function. The reasons for poor regeneration include significant cell damage secondary to oxidative stress, poor recruitment of resident stem cells, and an unfavorable microenvironment for tissue regeneration. Stem cell-based therapy was once thought as a potential therapy in tissue regeneration, due to its self-renewal and multipotent capabilities. Early advocates for cellular-based therapy pointed to the pluripotent nature of stem cells, thus eluding to its ability to differentiate into resident cells as the source of its regenerative capability. However, increasing evidence has revealed a lack of engraftment and differentiation of stem cells, thereby pointing to stem cell paracrine activity as being responsible for its regenerative potential. Stem cell-conditioned media houses biomolecular factors that portray significant regenerative potential. Amniotic-derived stem cell-conditioned media (AFS-CM) has been of particular interest because of its ease of allocation and in vitro culture. The purpose of this review is to report the results of studies that assess the role of AFS-CM for nerve and muscle conditions. In this review, we will cover the effects of AFS-CM on cellular pathways, genes, and protein expression for different nerve and muscle cell types.

Controlled degradable chitosan/collagen composite scaffolds for application in nerve tissue regeneration

2019 ◽  
Vol 166 ◽  
pp. 73-85 ◽  
Author(s):  
Junzeng Si ◽  
Yanhong Yang ◽  
Xiaoling Xing ◽  
Feng Yang ◽  
Peiyan Shan
Keyword(s):  
Tissue Regeneration ◽  
Nerve Tissue ◽  
Composite Scaffolds

Patterning of Cells on Bioresist for Tissue Engineering Applications

2004 ◽  
Vol 845 ◽  
Author(s):  
Yusif Umar ◽  
Muthiah Thiyagarajan ◽  
Craig Halberstadt ◽  
K. E. Gonsalves
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Control Cell ◽  
Polymer Surface ◽  
Cell Distribution ◽  
Cell Orientation ◽  
Promote Cell Proliferation ◽  
Chemically Amplified ◽  
Polymeric Scaffolds ◽  
Materials Used

Engineering functional tissues and organs successfully depends on the ability to control cell orientation and distribution. Materials used for such purposes therefore have to be designed to facilitate cell distribution and eventually guide tissue regeneration in 3D.The field of tissue engineering hinges on developing degradable polymeric scaffolds that promote cell proliferation and expression of desired physiological behaviors through careful control of the polymer surface.The development of materials for tissue engineering and guided tissue regeneration has accelerated over the last decade.[1] It has been demonstrated that non-patterned cells are effectively not tissue. “Tissues require that cells be placed and hold precise places often with precise orientations” [2–3]. Cell patterning is therefore very important for tissue engineering. We have developed a biocompatible, biostable chemically amplified bioresist, with which patterns are generated without involving harsh chemical treatment.

scholarly journals Application of Stem Cells and Advanced Materials in Nerve Tissue Regeneration

2018 ◽  
Vol 2018 ◽  
pp. 1-2 ◽  
Author(s):  
Huaqiong Li ◽  
Adam Qingsong Ye ◽  
Ming Su
Keyword(s):  
Stem Cells ◽  
Tissue Regeneration ◽  
Advanced Materials ◽  
Nerve Tissue
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