Endogenous Hypoxia Markers: Case Not Proven!

2008 ◽  
pp. 127-136 ◽  
Author(s):  
Arnulf Mayer ◽  
Michael Höckel ◽  
Peter Vaupel
Keyword(s):  
Hypoxia Markers

scholarly journals Synthesis and Characterisation of a Boron-Rich Symmetric Triazine Bearing a Hypoxia-Targeting Nitroimidazole Moiety

Symmetry ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 202
Author(s):  
Tobias Hartwig Bünning ◽  
Luigi Panza ◽  
Abdel Kareem Azab ◽  
Barbara Muz ◽  
Silvia Fallarini ◽  
...  
Keyword(s):  
Tumor Tissue ◽  
High Ratio ◽  
Neutron Capture Therapy ◽  
Boron Compounds ◽  
The Core ◽  
Boron Neutron Capture ◽  
Starting Point ◽  
Primary Fibroblasts ◽  
Normal Human ◽  
Hypoxia Markers

Boron Neutron Capture Therapy (BNCT) is a binary therapy that promises to be suitable in treating many non-curable cancers. To that, the discovery of new boron compounds able to accumulate selectively in the tumour tissue is still required. Hypoxia, a deficiency of oxygen in tumor tissue, is a great challenge in the conventional treatment of cancer, because hypoxic areas are resistant to conventional anticancer treatments. 2-Nitroimidazole derivatives are known to be hypoxia markers due to their enrichment by bioreduction in hypoxic cells. In the present work, 2-nitroimidazole was chosen as the starting point for the synthesis of a new boron-containing compound based on a 1,3,5-triazine skeleton. Two o-carborane moieties were inserted to achieve a high ratio of boron on the molecular weight, exploiting a short PEG spacer to enhance the polarity of the compound and outdistance the active part from the core. The compound showed no toxicity on normal human primary fibroblasts, while it showed noteworthy toxicity in multiple myeloma cells together with a consistent intracellular boron accumulation.

Prognostic values of pathologic findings and hypoxia markers in 21 patients with salivary duct carcinoma

2008 ◽  
Vol 97 (7) ◽  
pp. 596-600 ◽  
Author(s):  
Jong-Lyel Roh ◽  
Kyung-Ja Cho ◽  
Gui Young Kwon ◽  
Seung-Ho Choi ◽  
Soon Yuhl Nam ◽  
...  
Keyword(s):  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Pathologic Findings ◽  
Hypoxia Markers

Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas

2012 ◽  
Vol 113 (4) ◽  
pp. 464-471 ◽  
Author(s):  
Tomohiro Yamada ◽  
Moritoshi Uchida ◽  
Kang Kwang-Lee ◽  
Naoya Kitamura ◽  
Tomohide Yoshimura ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas ◽  
Hypoxia Markers

Expression of p16INK4A but not hypoxia markers or poly adenosine diphosphate-ribose polymerase is associated with improved survival in patients with pancreatic adenocarcinoma

Cancer ◽  
2010 ◽  
Vol 116 (22) ◽  
pp. 5179-5187 ◽  
Author(s):  
Daniel T. Chang ◽  
Christopher H. Chapman ◽  
Jeffrey A. Norton ◽  
Brendan Visser ◽  
George A. Fisher ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Adenosine Diphosphate ◽  
Hypoxia Markers

Microwave-assisted (radio)halogenation of nitroimidazole-based Hypoxia markers

2002 ◽  
Vol 57 (5) ◽  
pp. 697-703 ◽  
Author(s):  
P Kumar ◽  
L.I Wiebe ◽  
M Asikoglu ◽  
M Tandon ◽  
A.J.B McEwan
Keyword(s):  
Microwave Assisted ◽  
Hypoxia Markers
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