Diagnostic Techniques in Clinical Practice – OCT, FA, Ultrasound

2010 ◽  
pp. 121-139
Author(s):  
Keye Wong
Keyword(s):  
Clinical Practice ◽  
Diagnostic Techniques

THE COMPARISON OF THREE METHODS FOR CHROMOSOMAL ABNORMALITY DETECTION

2006 ◽  
Vol 04 (06) ◽  
pp. 1217-1226 ◽  
Author(s):  
TIMUR S. SHAKUOV
Keyword(s):  
Clinical Practice ◽  
Chromosomal Abnormality ◽  
Array Cgh ◽  
Diagnostic Techniques ◽  
Comparative Genome Hybridization ◽  
Abnormality Detection ◽  
Edge Detector ◽  
Biochemical Method ◽  
Processing Data ◽  
In The Beginning

The connection between certain human diseases and abnormal changes in chromosomes was discovered nearly 50 years ago. However, the detection of these abnormalities turned out to be a difficult task because both microscopic technologies and biochemical diagnostic techniques have their limitations. In the beginning of the century, a method for multiple comparative genome hybridization (array CGH) was introduced and is now been widely used in clinical practice for biochemical diagnostics. The application of array CGH greatly reduces the statistical errors, but not the noise in the results. As such, the time and material expenses necessary for reliable localization of abnormal parts of chromosomes by the means of biochemical techniques, is not significantly reduced. Algorithms for localization of contrast parts in noisy sequences can improve the situation. We implemented and tested two algorithms for this purpose. The first is the "edge detector" algorithm introduced by J. Canny. The second one is the DotHelix algorithm developed by A. M. Leontovich, L. I. Brodsky, and A. E. Gorbalenya. In this paper we compare the two implementations against biochemical method in processing data produced by array CGH.

scholarly journals Controlled Attenuation Parameter for Quantification of Steatosis: Which Cut-Offs to Use?

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Roxana Sirli ◽  
Ioan Sporea
Keyword(s):  
Clinical Practice ◽  
Liver Disease ◽  
Public Health Problem ◽  
Diagnostic Techniques ◽  
Chronic Viral Hepatitis ◽  
Controlled Attenuation Parameter ◽  
Noninvasive Technique ◽  
Nonalcoholic Fatty Liver ◽  
Attenuation Parameter ◽  
The Us

Chronic liver diseases (CLDs) are a public health problem, even if frequently they are underdiagnosed. Hepatic steatosis (HS), encountered not only in nonalcoholic fatty liver disease (NAFLD) but also in chronic viral hepatitis, alcoholic liver disease, etc., plays an important role in fibrosis progression, regardless of CLD etiology; thus, detection and quantification of HS are imperative. Controlled attenuation parameter (CAP) feature, implemented in the FibroScan® device, measures the attenuation of the US beam as it passes through the liver. It is a noninvasive technique, feasible and well accepted by patients, with lower costs than other diagnostic techniques, with acceptable accuracy for HS quantification. Multiple studies have been published regarding CAP performance to quantify steatosis, but due to the heterogeneity of CLD etiologies, of steatosis prevalence, etc., it had widely variable calculated cut-off values, which in turn limited the day-to-day utility of CAP measurements in clinical practice. This paper reviews published studies trying to suggest cut-off values usable in clinical practice.

scholarly journals Non-invasive diagnostics of liver fibrosis: recent data on the possibilities of instrumental techniques

2020 ◽  
Vol 4 (5) ◽  
pp. 297-301
Author(s):  
E.A. Kulebina ◽  
◽  
A.N. Surkov ◽  
O.V. Usoltseva ◽  
◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Fibrosis ◽  
Liver Biopsy ◽  
Subcutaneous Fat ◽  
Diagnostic Techniques ◽  
Chronic Liver ◽  
Diagnostic Methods ◽  
Limiting Factor ◽  
Non Invasive ◽  
Invasive Diagnostics

ABSTRACT Liver fibrosis is a progressive pathological process that develops in chronic liver disease. This pathology can lead to cirrhosis. Liver biopsy remains the gold standard for evaluation of liver fibrosis, currently, though, non-invasive diagnostic methods are being actively introduced into clinical practice. Unlike liver biopsies, most non-invasive instrumental techniques are easy to perform, accessible, and repeatable, making them more convenient for evaluating dynamic fibrotic change. The review summarizes the main principles of non-invasive instrumental techinques for assessment of liver fibrosis severity, which have been studied and put into practice in recent years. The most widely used techniques in clinical practice are based on principles of elastography — it indirectly determines the organ tissue density. The techniques are characterized by different sensitivity and specificity in the diagnosis of fibrosis. The main issues arise when differentiating the disease stages. For some techniques, the limitation of use is ascites, excessive subcutaneous fat, whereas the main limiting factor for others is the high cost of the procedure. Meanwhile, there is every reason to believe that non-invasive techniques can take the main place in the diagnosis of liver fibrosis and replace biopsy in the foreseeable future. KEYWORDS: liver fibrosis, chronic liver diseases, non-invasive diagnostic techniques, elastography, liver biopsy, magnetic resonance imaging, ultrasound. FOR CITATION: Kulebina E.A., Surkov A.N., Usoltseva O.V. Non-invasive diagnostics of liver fibrosis: recent data on the possibilities of instrumental techniques. Russian Medical Review. 2020;4(5):297–301. DOI: 10.32364/2587-6821-2020-4-5-297-301.

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Diseases ◽  
Hepatic Disease ◽  
Noninvasive Detection ◽  
Diagnosis And Prognosis ◽  
Expected Performance ◽  
Potential Biomarker ◽  
Disease Condition ◽  
Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Meeting the Best Practice for Hearing Aid Verification in Children: Challenges and Future Directions

2019 ◽  
Vol 28 (4) ◽  
pp. 877-894
Author(s):  
Nur Azyani Amri ◽  
Tian Kar Quar ◽  
Foong Yen Chong
Keyword(s):  
Clinical Practice ◽  
Hearing Aids ◽  
Best Practice ◽  
Hearing Aid ◽  
Evidence Based ◽  
Future Directions ◽  
Major Barrier ◽  
Klang Valley ◽  
Age Range ◽  
Fitting Hearing Aids

Purpose This study examined the current pediatric amplification practice with an emphasis on hearing aid verification using probe microphone measurement (PMM), among audiologists in Klang Valley, Malaysia. Frequency of practice, access to PMM system, practiced protocols, barriers, and perception toward the benefits of PMM were identified through a survey. Method A questionnaire was distributed to and filled in by the audiologists who provided pediatric amplification service in Klang Valley, Malaysia. One hundred eight ( N = 108) audiologists, composed of 90.3% women and 9.7% men (age range: 23–48 years), participated in the survey. Results PMM was not a clinical routine practiced by a majority of the audiologists, despite its recognition as the best clinical practice that should be incorporated into protocols for fitting hearing aids in children. Variations in practice existed warranting further steps to improve the current practice for children with hearing impairment. The lack of access to PMM equipment was 1 major barrier for the audiologists to practice real-ear verification. Practitioners' characteristics such as time constraints, low confidence, and knowledge levels were also identified as barriers that impede the uptake of the evidence-based practice. Conclusions The implementation of PMM in clinical practice remains a challenge to the audiology profession. A knowledge-transfer approach that takes into consideration the barriers and involves effective collaboration or engagement between the knowledge providers and potential stakeholders is required to promote the clinical application of evidence-based best practice.

Hybrid Telecoaching for Corporate Speech Training and Potential Applications to Clinical Practice

2019 ◽  
Vol 4 (2) ◽  
pp. 322-324
Author(s):  
Thomas F. Burke
Keyword(s):  
Clinical Practice ◽  
Engineering Teams ◽  
Corporate Strategies ◽  
Corporate Speech ◽  
Phone Calls ◽  
Future Clinical Practice ◽  
Fortune 100 ◽  
Potential Applications ◽  
Language Pathology ◽  
Development Engineering

Purpose The purpose of this article was to describe a model for “hybrid speech telecoaching” developed for a Fortune 100 organization and offer a “thought starter” on how clinicians might think of applying these corporate strategies within future clinical practice. Conclusion The author contends in this article that corporate telecommunications and best practices gleaned from software development engineering teams can lend credibility to e-mail, messaging apps, phone calls, or other emerging technology as viable means of hybrid telepractice delivery models and offer ideas about the future of more scalable speech-language pathology services.

What Does Evidence-Based Practice Mean to You? A Follow-Up Study Examining School-Based Speech-Language Pathologists' Perspectives on Evidence-Based Practice

2020 ◽  
Vol 29 (2) ◽  
pp. 688-704
Author(s):  
Katrina Fulcher-Rood ◽  
Anny Castilla-Earls ◽  
Jeff Higginbotham
Keyword(s):  
Clinical Practice ◽  
Research Evidence ◽  
Evidence Based Practice ◽  
Evidence Based ◽  
Clinical Expertise ◽  
Speech Language Pathologists ◽  
School Based ◽  
Research Findings ◽  
Ebp Implementation

Purpose The current investigation is a follow-up from a previous study examining child language diagnostic decision making in school-based speech-language pathologists (SLPs). The purpose of this study was to examine the SLPs' perspectives regarding the use of evidence-based practice (EBP) in their clinical work. Method Semistructured phone interviews were conducted with 25 school-based SLPs who previously participated in an earlier study by Fulcher-Rood et al. 2018). SLPs were asked questions regarding their definition of EBP, the value of research evidence, contexts in which they implement scientific literature in clinical practice, and the barriers to implementing EBP. Results SLPs' definitions of EBP differed from current definitions, in that SLPs only included the use of research findings. SLPs seem to discuss EBP as it relates to treatment and not assessment. Reported barriers to EBP implementation were insufficient time, limited funding, and restrictions from their employment setting. SLPs found it difficult to translate research findings to clinical practice. SLPs implemented external research evidence when they did not have enough clinical expertise regarding a specific client or when they needed scientific evidence to support a strategy they used. Conclusions SLPs appear to use EBP for specific reasons and not for every clinical decision they make. In addition, SLPs rely on EBP for treatment decisions and not for assessment decisions. Educational systems potentially present other challenges that need to be considered for EBP implementation. Considerations for implementation science and the research-to-practice gap are discussed.

Issues in Language Sample Collection and Analysis With Children Using AAC

2014 ◽  
Vol 23 (2) ◽  
pp. 65-74 ◽  
Author(s):  
Gail Van Tatenhove
Keyword(s):  
Clinical Practice ◽  
Augmentative And Alternative Communication ◽  
Language Production ◽  
Expressive Language ◽  
Sample Analysis ◽  
Alternative Communication ◽  
Sample Collection ◽  
Speech Language Pathologists ◽  
Language Sample Analysis ◽  
Language Sample

Language sample analysis is considered one of the best methods of evaluating expressive language production in speaking children. However, the practice of language sample collection and analysis is complicated for speech-language pathologists working with children who use augmentative and alternative communication (AAC) devices. This article identifies six issues regarding use of language sample collection and analysis in clinical practice with children who use AAC devices. The purpose of this article is to encourage speech-language pathologists practicing in the area of AAC to utilize language sample collection and analysis as part of ongoing AAC assessment.

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