Differentiating Human Pluripotent Stem Cells to Vascular Endothelial Cells for Regenerative Medicine, Tissue Engineering, and Disease Modeling

2021 ◽  
pp. 1-12
Author(s):  
Taylor Bertucci ◽  
Shravani Kakarla ◽  
Diana Kim ◽  
Guohao Dai
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Endothelial Cells ◽  
Regenerative Medicine ◽  
Pluripotent Stem Cells ◽  
Disease Modeling ◽  
Vascular Endothelial Cells ◽  
Human Pluripotent Stem Cells ◽  
Vascular Endothelial

scholarly journals Tooth Slice/Scaffold Model of Dental Pulp Tissue Engineering

2011 ◽  
Vol 23 (3) ◽  
pp. 325-332 ◽  
Author(s):  
V.T. Sakai ◽  
M.M. Cordeiro ◽  
Z. Dong ◽  
Z. Zhang ◽  
B.D. Zeitlin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Endothelial Cells ◽  
Dental Pulp ◽  
Vascular Endothelial Cells ◽  
Dental Pulp Stem Cells ◽  
Vascular Endothelial ◽  
Pulp Tissue ◽  
Differentiation Potential ◽  
Dental Pulp Tissue

Multipotency is a defining characteristic of post-natal stem cells. The human dental pulp contains a small subpopulation of stem cells that exhibit multipotency, as demonstrated by their ability to differentiate into odontoblasts, neural cells, and vascular endothelial cells. These discoveries highlight the fundamental role of stem cells in the biology of the dental pulp and suggest that these cells are uniquely suited for dental pulp tissue-engineering purposes. The availability of experimental approaches specifically designed for studies of the differentiation potential of dental pulp stem cells has played an important role in these discoveries. The objective of this review is to describe the development and characterization of the Tooth Slice/Scaffold Model of Dental Pulp Tissue Engineering. In addition, we discuss the multipotency of dental pulp stem cells, focusing on the differentiation of these cells into functional odontoblasts and into vascular endothelial cells.

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