Modelling Stochastic Transmission Processes in Helminth Infections

2010 ◽  
pp. 66-78 ◽  
Author(s):  
Stephen J. Cornell
Keyword(s):  
Helminth Infections

scholarly journals Effect of intensive treatment for schistosomiasis on immune responses to vaccines among rural Ugandan island adolescents: randomised controlled trial protocol A for the ‘POPulation differences in VACcine responses’ (POPVAC) programme

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e040426
Author(s):  
Gyaviira Nkurunungi ◽  
Ludoviko Zirimenya ◽  
Jacent Nassuuna ◽  
Agnes Natukunda ◽  
Prossy N Kabuubi ◽  
...  
Keyword(s):  
Immune Responses ◽  
Low Income ◽  
Controlled Trial ◽  
Interferon Γ ◽  
Population Differences ◽  
Vaccine Response ◽  
Vaccine Responses ◽  
Helminth Infections ◽  
Registration Number ◽  
Randomised Controlled

IntroductionSeveral licensed and investigational vaccines have lower efficacy, and induce impaired immune responses, in low-income versus high-income countries and in rural, versus urban, settings. Understanding these population differences is essential to optimising vaccine effectiveness in the tropics. We suggest that repeated exposure to and immunomodulation by chronic helminth infections partly explains population differences in vaccine response.Methods and analysisWe have designed an individually randomised, parallel group trial of intensive versus standard praziquantel (PZQ) intervention against schistosomiasis, to determine effects on vaccine response outcomes among school-going adolescents (9–17 years) from rural Schistosoma mansoni-endemic Ugandan islands. Vaccines to be studied comprise BCG on day ‘zero’; yellow fever, oral typhoid and human papilloma virus (HPV) vaccines at week 4; and HPV and tetanus/diphtheria booster vaccine at week 28. The intensive arm will receive PZQ doses three times, each 2 weeks apart, before BCG immunisation, followed by a dose at week 8 and quarterly thereafter. The standard arm will receive PZQ at week 8 and 52. We expect to enrol 480 participants, with 80% infected with S. mansoni at the outset.Primary outcomes are BCG-specific interferon-γ ELISpot responses 8 weeks after BCG immunisation and for other vaccines, antibody responses to key vaccine antigens at 4 weeks after immunisation. Secondary analyses will determine the effects of intensive anthelminthic treatment on correlates of protective immunity, on waning of vaccine response, on priming versus boosting immunisations and on S. mansoni infection status and intensity. Exploratory immunology assays using archived samples will enable assessment of mechanistic links between helminths and vaccine responses.Ethics and disseminationEthics approval has been obtained from relevant ethics committes of Uganda and UK. Results will be shared with Uganda Ministry of Health, relevant district councils, community leaders and study participants. Further dissemination will be done through conference proceedings and publications.Trial registration numberISRCTN60517191.

scholarly journals Helminth infections in fish in Vietnam: A systematic review

2021 ◽  
Vol 14 ◽  
pp. 13-32
Author(s):  
Trang Huyen Nguyen ◽  
Pierre Dorny ◽  
Thanh Thi Giang Nguyen ◽  
Veronique Dermauw
Keyword(s):  
Systematic Review ◽  
Helminth Infections

scholarly journals The risk of helminth infections at Endangered Primate Rescue Center, Cuc Phuong National Park Vietnam

2021 ◽  
Vol 788 (1) ◽  
pp. 012156
Author(s):  
Hoai-Nam Vu ◽  
Ha-My Cong ◽  
Nam-Trieu Tran ◽  
Duy-Thanh Vo ◽  
C Rowley ◽  
...  
Keyword(s):  
National Park ◽  
Helminth Infections ◽  
Rescue Center

scholarly journals Concomitant Plasmodium falciparum and intestinal helminth infections in a rural community of southern Côte d’lvoire

2012 ◽  
Vol 11 (S1) ◽  
Author(s):  
Richard B Yapi ◽  
Eveline Hürlimann ◽  
Kigbafori D Silué ◽  
Clarisse A Houngbedji ◽  
Chammartin Frédérigue ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Rural Community ◽  
Intestinal Helminth ◽  
Helminth Infections

scholarly journals Helminth infections in the US military: from strongyloidiasis to schistosomiasis

2021 ◽  
Author(s):  
Alyssa R Lindrose ◽  
Indrani Mitra ◽  
Jamie Fraser ◽  
Edward Mitre ◽  
Patrick W Hickey
Keyword(s):  
Military Personnel ◽  
International Classification Of Diseases ◽  
Data Repository ◽  
Military Health ◽  
Intestinal Nematode ◽  
Us Military ◽  
Helminth Infections ◽  
The Us ◽  
East And Southeast Asia ◽  
The Military

Abstract Background Helminth infections caused by parasitic worms, including nematodes (roundworms), cestodes (tapeworms) and trematodes (flukes), can cause chronic symptoms and serious clinical outcomes if left untreated. The US military frequently conducts activities in helminth-endemic regions, particularly Africa, the Middle East and Southeast Asia. However, the military does not currently screen for these infections, and to date, no comprehensive surveillance studies have been completed to assess the frequency of helminth diagnoses in the military personnel and their families. Methods To determine the burden of helminth infections in the US Military Health System (MHS), we conducted a retrospective analysis of International Classification of Diseases (ICD)-9/10 diagnosis codes from all medical encounters in the MHS Data Repository (MDR) from fiscal years (FY) 2012 to 2018. Chart reviews were conducted to assign ICD diagnoses as incorrect, suspected, probable or confirmed based on the laboratory results and symptoms. Results Abstraction of MHS data revealed over 50 000 helminth diagnoses between FY 2012 and FY 2018. Of these, 38 445 of diagnoses were amongst unique subjects. After chart review, we found there were 34 425 validated helminth infections diagnosed amongst the unique subjects of US military personnel, retirees and dependents. Nearly 4000 of these cases represented infections other than enterobiasis. There were 351 validated strongyloidiasis diagnoses, 317 schistosomiasis diagnoses and 191 diagnoses of cysticercosis during the study period. Incidence of intestinal nematode infection diagnoses showed an upward trend, whilst the incidence of cestode infection diagnoses decreased. Conclusions The results of this study demonstrate that helminth infections capable of causing severe morbidity are often diagnosed in the US military. As helminth infections are often asymptomatic or go undiagnosed, the true burden of helminth infections in US military personnel and dependents may be higher than observed here. Prospective studies of US military personnel deployed to helminth-endemic areas may be indicated to determine if post-deployment screening and/or empirical treatment are warranted.

scholarly journals Chronic Wasting Due to Liver and Rumen Flukes in Sheep

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 549
Author(s):  
Alexandra Kahl ◽  
Georg von Samson-Himmelstjerna ◽  
Jürgen Krücken ◽  
Martin Ganter
Keyword(s):  
Fasciola Hepatica ◽  
Clinical Symptoms ◽  
Current Knowledge ◽  
Infection Intensity ◽  
Liver Parenchyma ◽  
Trematode Species ◽  
Helminth Infections ◽  
Juvenile Worm ◽  
Juvenile Stages ◽  
Common Liver Fluke

Grazing sheep and goats are constantly exposed to helminth infections in many parts of the world, including several trematode species that causes a range of clinical diseases. The clinical picture of flukes is dependent upon the organs in which they develop and the tissues they damage within the respective organs. Accordingly, infections with the common liver fluke Fasciola hepatica, which, as juvenile worm migrates through the liver parenchyma for several weeks, may be associated with hepatic disorders such as impairment of carbohydrate, protein and fat metabolism, followed by chronic wasting. In contrast, the lancet fluke Dicrocoelium dendriticum, which does not exhibit tissue migration and thus does not lead to major tissue damage and bleeding, also does not lead to significant clinical symptoms. Rumen flukes such as Cotylophoron daubneyi cause catarrhal inflammation during their migration through the intestinal and abomasal epithelium during its juvenile stages. Depending on the infection intensity this may result in a range of clinical symptoms including diarrhoea, inappetence or emaciation. In this review, we aim to provide an update on the current knowledge on flukes particularly concerning the clinical relevance of the most important fluke species in sheep.

Cardioprotective manifestations of chronic helminth infections: new aspects of an old disease

Heart ◽  
2017 ◽  
Vol 103 (20) ◽  
pp. 1651.1-1651 ◽  
Author(s):  
Amir Abdoli ◽  
Sima Rasti
Keyword(s):  
Helminth Infections

scholarly journals The promise and pitfalls of mass drug administration to control intestinal helminth infections

2012 ◽  
Vol 25 (5) ◽  
pp. 584-589 ◽  
Author(s):  
Debbie Humphries ◽  
Sara Nguyen ◽  
Daniel Boakye ◽  
Michael Wilson ◽  
Michael Cappello
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Intestinal Helminth ◽  
Helminth Infections
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