scholarly journals The promise and pitfalls of mass drug administration to control intestinal helminth infections

2012 ◽  
Vol 25 (5) ◽  
pp. 584-589 ◽  
Author(s):  
Debbie Humphries ◽  
Sara Nguyen ◽  
Daniel Boakye ◽  
Michael Wilson ◽  
Michael Cappello
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Intestinal Helminth ◽  
Helminth Infections

Current WHO protocols for mass drug administration in helminth control

2016 ◽  
Vol 37 (1) ◽  
pp. 10
Author(s):  
Richard S Bradbury ◽  
Patricia M Graves
Keyword(s):  
Vector Control ◽  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Target Population ◽  
Preventive Chemotherapy ◽  
Soil Transmitted Helminths ◽  
Helminth Infections ◽  
The World ◽  
Control Criteria

Soil transmitted helminths (STH), comprising Ascaris, Trichuris, Strongyloides and the hookworms remain a significant cause of morbidity amongst people in many parts of the world, including Australia. Other important helminth infections include lymphatic filariasis (LF), schistosomiasis and onchocerciasis. Preventive chemotherapy (mass drug administration [MDA]) campaigns are frequently conducted for these helminth infections in endemic areas, but the target population groups, duration of campaigns, cointerventions (e.g. vector control) criteria for inclusion, drugs used and doses of drugs differ.

scholarly journals Soil‐transmitted helminth infections after mass drug administration for lymphatic filariasis in rural southern India

2021 ◽  
Author(s):  
Saravanakumar Puthupalayam Kaliappan ◽  
Karthikeyan Ramanujam ◽  
Malathi Manuel ◽  
Jasmine Farzana ◽  
Venkateshprabhu Janagaraj ◽  
...  
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Southern India ◽  
Helminth Infections

scholarly journals Impact of Annual versus Semiannual Mass Drug Administration with Ivermectin and Albendazole on Helminth Infections in Southeastern Liberia

2021 ◽  
Author(s):  
Obiora A. Eneanya ◽  
Lincoln Gankpala ◽  
Charles W. Goss ◽  
Fatorma K. Bolay ◽  
Gary J. Weil ◽  
...  
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Wuchereria Bancrofti ◽  
Infection Prevalence ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Helminth Infections ◽  
Helminthic Infections ◽  
Prevalence Estimates ◽  
The Impact

We compared the impact of three rounds of annual and five rounds of semiannual mass drug administration (MDA) with albendazole plus ivermectin on helminthic infections in Liberia. Repeated annual cross-sectional community surveys were conducted between 2013 and 2019 in individuals of 5 years and older. Primary outcome was the change of infection prevalence estimates from baseline to month 36 (12 months after the last treatment). After three rounds of annual MDA, Wuchereria bancrofti circulating filarial antigen (CFA) and microfilaria (Mf) prevalence estimates decreased from 19.7% to 4.3% and from 8.6% to 0%, respectively; after semiannual MDA, CFA and Mf prevalences decreased from 37.8% to 16.8% and 17.9% to 1%, respectively. Mixed effects logistic regression models indicated that the odds of having Mf decreased by 97% (P < 0.001) at month 36 (similar odds for annual and semiannual MDA zones). A parallel analysis showed that the odds of CFA were reduced by 83% and 69% at 36 months in the annual and semiannual treatment zones, respectively (P < 0.001). Onchocerca volvulus Mf prevalence decreased slightly after multiple MDA rounds in both treatment zones. Reductions in hookworm and Trichuris trichiura prevalences and intensities were slightly greater in the annual treatment zone. Ascaris lumbricoides prevalence rates were relatively unchanged, although infection intensities decreased sharply throughout. Results show that annual and semiannual MDA were equally effective for reducing LF and soil-transmitted helminth infection parameters over a 3-year period, and reductions recorded at month 36 were sustained by routine annual MDA through month 72.

scholarly journals Rapid Wuchereria bancrofti-Specific Antigen Wb123-Based IgG4 Immunoassays as Tools for Surveillance following Mass Drug Administration Programs on Lymphatic Filariasis

2013 ◽  
Vol 20 (8) ◽  
pp. 1155-1161 ◽  
Author(s):  
Cathy Steel ◽  
Allison Golden ◽  
Joseph Kubofcik ◽  
Nicole LaRue ◽  
Tala de los Santos ◽  
...  
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Wuchereria Bancrofti ◽  
Lateral Flow ◽  
Enzyme Linked Immunosorbent Assay ◽  
Predictive Values ◽  
Content Type ◽  
Helminth Infections ◽  
Highly Sensitive

ABSTRACTThe Global Programme to Eliminate Lymphatic Filariasis has an urgent need for rapid assays to detect ongoing transmission of lymphatic filariasis (LF) following multiple rounds of mass drug administration (MDA). Current WHO guidelines support using the antigen card immunochromatographic test (ICT), which detects active filarial infection but does not detect early exposure to LF. Recent studies found that antibody-based assays better serve this function. In the present study, two tests, a rapid IgG4 enzyme-linked immunosorbent assay (ELISA) and a lateral-flow strip immunoassay, were developed based on the highly sensitive and specificWuchereria bancroftiantigen Wb123. A comparison ofW. bancrofti-infected and -uninfected patients (with or without other helminth infections) demonstrated that both tests had high sensitivities and specificities (93 and 97% [ELISA] and 92 and 96% [strips], respectively). When theW. bancrofti-uninfected group was separated into those with other filarial/helminth infections (i.e., onchocerciasis, loiasis, and strongyloidiasis) and those who were parasite uninfected, the specificities of the assays varied between 91 and 100%. In addition, the geometric mean response by ELISA ofW. bancrofti-infected patients was significantly higher than the response of those withoutW. bancroftiinfection (P< 0.0001). Furthermore, the Wb123 ELISA and the lateral-flow strips had high positive and negative predictive values, giving valuable information on the size of survey population needed to be reasonably certain whether or not transmission is ongoing. These highly sensitive and specific IgG4 tests to theW. bancroftiWb123 protein give every indication that they will serve as useful tools for post-MDA monitoring.

scholarly journals The coverage and frequency of mass drug administration required to eliminate persistent transmission of soil-transmitted helminths

2014 ◽  
Vol 369 (1645) ◽  
pp. 20130435 ◽  
Author(s):  
Roy Anderson ◽  
James Truscott ◽  
T. Deirdre Hollingsworth
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Cost Effective ◽  
Epidemiological Data ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Soil Transmitted Helminths ◽  
School Aged Children ◽  
Helminth Infections

A combination of methods, including mathematical model construction, demographic plus epidemiological data analysis and parameter estimation, are used to examine whether mass drug administration (MDA) alone can eliminate the transmission of soil-transmitted helminths (STHs). Numerical analyses suggest that in all but low transmission settings (as defined by the magnitude of the basic reproductive number, R 0 ), the treatment of pre-school-aged children (pre-SAC) and school-aged children (SAC) is unlikely to drive transmission to a level where the parasites cannot persist. High levels of coverage (defined as the fraction of an age group effectively treated) are required in pre-SAC, SAC and adults, if MDA is to drive the parasite below the breakpoint under which transmission is eliminated. Long-term solutions to controlling helminth infections lie in concomitantly improving the quality of the water supply, sanitation and hygiene (WASH). MDA, however, is a very cost-effective tool in long-term control given that most drugs are donated free by the pharmaceutical industry for poor regions of the world. WASH interventions, by lowering the basic reproductive number, can facilitate the ability of MDA to interrupt transmission.

scholarly journals Effectiveness of Mass Drug Administration on Neglected Tropical Diseases in Schoolchildren in Zanzibar, Tanzania

2020 ◽  
Vol 58 (2) ◽  
pp. 109-119
Author(s):  
Ju Yeong Kim ◽  
Seobo Sim ◽  
Eun Joo Chung ◽  
Han-Jong Rim ◽  
Jong-Yil Chai ◽  
...  
Keyword(s):  
Infection Rate ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Neglected Tropical Diseases ◽  
Sub Saharan Africa ◽  
Infection Rates ◽  
Control Programs ◽  
Hygiene Behavior ◽  
Helminth Infections ◽  
Sub Saharan

Soil-transmitted helminths and <i>Schistosoma haematobium</i> affect more than 3 billion people globally and mainly occur in sub-Saharan Africa. The present study assessed the overall infection status of a 1716-student cohort of school-children in Zanzibar and applied mass drug administration (MDA) to the cohort from 2007 to 2009. Schools in Pemba, Zanzibar, had a much higher prevalence of soil-transmitted helminth infections than those in Unguja, and the Chaani, Ghana, and Machui schools of Unguja exhibited high <i>S. haematobium</i> infection rates. The MDA program only partially controlled parasite infections, owing to high rates of re-infection. The infection rate of <i>S. haematobium</i> across all 10 schools, for example, was only reduced by 1.8%, and even this change not significant, even though the <i>S. haematobium</i>infection rates of the Chaani and Mzambarauni schools were significantly reduced from 64.4 and 23.4%, respectively, at the first screening, to 7.3 and 2.3% at the last screening. The overall infection rate of <i>Ascaris lumbricoides</i> was reduced from 36.0% at the first screening to 22.6% at the last screening. However, the infection rates for both <i>Trichuris trichiura</i>and hookworm were generally unaffected by MDA. In the future, parasite control programs should involve strategically designed MDA schedules and holistic intervention (e.g., sanitation improvement, hygiene behavior changes, and control of intermediated hosts).

scholarly journals Impact of Six Rounds of Mass Drug Administration on Brugian Filariasis and Soil-Transmitted Helminth Infections in Eastern Indonesia

2013 ◽  
Vol 7 (12) ◽  
pp. e2586 ◽  
Author(s):  
Taniawati Supali ◽  
Yenny Djuardi ◽  
Mark Bradley ◽  
Rahmah Noordin ◽  
Paul Rückert ◽  
...  
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Eastern Indonesia ◽  
Helminth Infections
Sign in / Sign up

Export Citation Format

Share Document