Surgical Approach to Locally Recurrent Disease

2001 ◽  
pp. 147-156
Author(s):  
C. A. Paterson ◽  
H. Nelson
Keyword(s):  
Surgical Approach ◽  
Recurrent Disease ◽  
Locally Recurrent

Surgical Approach to Locally Recurrent Disease

2014 ◽  
pp. 271-286
Author(s):  
Leandro Feo ◽  
Michael Polcino ◽  
Julio Garcia-Aguilar
Keyword(s):  
Surgical Approach ◽  
Recurrent Disease ◽  
Locally Recurrent

Medulloblastoma in children

1977 ◽  
Vol 46 (1) ◽  
pp. 56-64 ◽  
Author(s):  
John Mealey ◽  
Peter V. Hall
Keyword(s):  
Recurrent Disease ◽  
Fatal Outcome ◽  
Primary Treatment ◽  
Cerebellar Tumor ◽  
Content Type ◽  
Drug Of Choice ◽  
Spinal Axis ◽  
Postoperative Irradiation ◽  
Locally Recurrent ◽  
Higher Doses

✓ The authors review treatment and results in 45 cases of medulloblastoma arising in childhood. The surgical mortality rate observed was 11%. Of those completing postoperative cerebrospinal irradiation at this institution, 53% have survived for 3 years, 41% for 5 years, and 22% for 10 years. The extent of surgical resection of the cerebellar tumor had no significant bearing on the prognosis. Those cases remaining free of recurrent disease had received significantly higher doses of postoperative irradiation, approaching 5000 rads to the whole brain or posterior fossa and 4000 rads to the spinal axis. Repeat irradiation and chemotherapy (vincristine, the nitrosoureas, and methotrexate) provided good palliation in most cases and significantly extended the survival time. However, 28 of 29 patients who developed locally recurrent or metastatic disease have died. Vincristine was considered the chemotherapeutic drug of choice and in 14 cases its use was associated with remissions lasting 2 to 18 months. The combination of chemotherapy and repeat irradiation was followed by remissions of longer duration compared to retreatment by irradiation alone when the disease recurred within 2 years. The inherent value of ventricular shunting procedures and steroid therapy for recurrent intracranial disease could not be ascertained. The findings in this study suggest that the primary treatment of medulloblastoma should be extended to include chemotherapy and optimum radiation therapy, since once recurrent disease develops retreatment is essentially palliative and a fatal outcome is virtually certain.

Pediatric Functional Endoscopic Sinus Surgery

1996 ◽  
Vol 10 (6) ◽  
pp. 343-346 ◽  
Author(s):  
Glenn B. Rothman ◽  
David E. Tunkel ◽  
Fuad M. Baroody ◽  
Robert M. Naclerio
Keyword(s):  
Pediatric Patient ◽  
Surgical Approach ◽  
Endoscopic Sinus Surgery ◽  
Recurrent Disease ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Technical Considerations

Based on experience with functional endoscopic sinus surgery in over 200 children, we suggest that technical considerations modify the approach in the pediatric patient. We present details of our surgical approach with emphasis on modifying the uncinectomy. We believe our modifications reduce the incidence of recurrent disease.

The use of hyperthermia to overcome tumour hypoxia in the treatment of advanced breast cancer

2008 ◽  
Vol 7 (01) ◽  
pp. 39-46
Author(s):  
Helen Netherton
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Recurrent Disease ◽  
Advanced Breast ◽  
Tumour Hypoxia ◽  
Locally Recurrent ◽  
Recurrent Breast ◽  
Randomised Controlled ◽  
Positive Effect ◽  
Positive Results

AbstractPurpose:The purpose of this review was to explore the literature on the use of hyperthermia (HT) in advanced breast cancer.Methods:A literature search was conducted to obtain information from recent trials of HT and/or chemotherapy (CH) and radiotherapy (RT) for patients with locally recurrent breast carcinoma. Issues concerned with patient compliance and side effects have also been reviewed and future recommendations for research made.Results:Results of recent trials have demonstrated promising outcomes for HT and RT in combination, particularly for recurrent disease to improve local control (LC). There is no evidence, however, to support a positive effect on overall survival.Conclusions:Despite positive results HT has not been widely embraced, due to financial and logistical limitations. Future recommendations include larger, randomised, controlled studies and the development of temperature mapping to avoid potentially limiting HT blisters.

Outcomes of Salvage Surgery for Cure in Patients With Locally Recurrent Disease After Local Excision of Rectal Cancer

2015 ◽  
Vol 58 (3) ◽  
pp. 283-287 ◽  
Author(s):  
Jai Bikhchandani ◽  
Gabie K. Ong ◽  
Eric J. Dozois ◽  
Kellie L. Mathis
Keyword(s):  
Rectal Cancer ◽  
Local Excision ◽  
Recurrent Disease ◽  
Salvage Surgery ◽  
Locally Recurrent

Relationship of chemotherapy-induced necrosis and surgical margins to local recurrence in osteosarcoma.

1994 ◽  
Vol 12 (12) ◽  
pp. 2699-2705 ◽  
Author(s):  
P Picci ◽  
L Sangiorgi ◽  
B T Rougraff ◽  
J R Neff ◽  
R Casadei ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Local Recurrence ◽  
Local Control ◽  
Recurrent Disease ◽  
Surgical Margins ◽  
Limb Salvage Surgery ◽  
Chemotherapy Response ◽  
Anatomic Site ◽  
Locally Recurrent

PURPOSE AND METHODS To assess patients with high-grade osteosarcoma treated at our institution for various prognostic factors for the development of local recurrence of disease. Follow-up data were available for all patients and the mean follow-up duration was 65 months in surviving patients. RESULTS There were 28 local recurrences in this study (7%). Of these, only three patients (11%) were alive at the most recent follow-up point, 28, 53, and 54 months after local recurrence. None of 59 patients who were treated primarily with a radical amputation and none of 10 who underwent a rotationplasty developed local recurrence. Four of 48 patients (8%) who had wide amputations, one of whom had an intralesional amputation, and 23 of 237 (10%) who had limb-salvage surgery developed locally recurrent disease. Of 237 patients who underwent limb-sparing resection, three prognostic factors for local control were identified. The strongest association with local recurrence was chemotherapy response (P < .0001), followed closely by surgical margins (P = .0001). Older patients were more likely to have locally recurrent disease (P = .033), with each decade of life older than the first decade having a relative risk of 1.5 times greater per decade (SE = 0.16; 95% confidence interval, 0.034 to .0650). Factors that were not associated with local recurrence included sex, date of diagnosis, and anatomic site of disease. CONCLUSION Chemotherapy-induced tumor necrosis and surgical margins are important prognostic factors for local control of patients with osteosarcoma.

Intrinsic Malignant Schwannoma of the Larynx

1982 ◽  
Vol 91 (3) ◽  
pp. 336-338 ◽  
Author(s):  
Howard L. DeLozier
Keyword(s):  
Recurrent Disease ◽  
Malignant Schwannoma ◽  
First Case ◽  
Locally Recurrent

The first case of an intrinsic laryngeal malignant schwannoma is reported. The diagnosis of a malignant schwannoma is difficult to establish without gross evidence of its origination in a nerve. Although surgery remains the mainstay of treatment, a combination of surgery and radiotherapy appears promising. The prognosis in most cases is poor, with death usually resulting from persistent or locally recurrent disease.

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