The Reality of Aging Viewed from the Arterial Wall

2014 ◽  
pp. 137-153 ◽  
Author(s):  
Majd AlGhatrif ◽  
Edward G. Lakatta
Keyword(s):  
Arterial Wall

66 Arterial wall properties in patients with chronic heart failure

2006 ◽  
Vol 5 (1) ◽  
pp. 11-12
Author(s):  
Z KOBALAVA ◽  
V MOISEEV ◽  
Y KOTOVSKAYA ◽  
G KIYAKBAEV ◽  
E OZOVA
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Arterial Wall ◽  
Wall Properties

Interventional Thermal Injury of the Arterial Wall: Unfolding of von Willebrand Factor and Its Increased Binding to Collagen after 55° C Heating

1996 ◽  
Vol 75 (03) ◽  
pp. 515-519 ◽  
Author(s):  
Mark J Post ◽  
Anke N de Graaf-Bos ◽  
George Posthuma ◽  
Philip G de Groot ◽  
Jan J Sixma ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Conformational Changes ◽  
Arterial Wall ◽  
Platelet Adhesion ◽  
Type I ◽  
Temperature Dependent ◽  
Collagen Types ◽  
Electron Microscopic ◽  
Von Willebrand ◽  
Willebrand Factor

Summary Purpose. Thermal angioplasty alters the thrombogenicity of the arterial wall. In previous studies, platelet adhesion was found to increase after heating human subendothelium to 55° C and decrease after heating to 90° C. In the present electron microscopic study, the mechanism of this temperature-dependent platelet adhesion to the heated arterial wall is elucidated by investigating temperature-dependent conformational changes of von Willebrand factor (vWF) and collagen types I and III and the binding of vWF to heated collagen. Methods. Purified vWF and/or collagen was applied to electron microscopic grids and heated by floating on a salt-solution of 37° C, 55° C or 90° C for 15 s. After incubation with a polyclonal antibody against vWF and incubation with protein A/gold, the grids were examined by electron microscopy. Results. At 37° C, vWF was coiled. At 55° C, vWF unfolded, whereas heating at 90° C caused a reduction in antigenicity. Collagen fibers heated to 37° C were 60.3 ± 3.1 nm wide. Heating to 55° C resulted in the unwinding of the fibers, increasing the width to 87.5 ± 8.2 nm (p < 0.01). Heating to 90° C resulted in denatured fibers with an enlarged width of 85.1 ± 6.1 nm (p < 0.05). Heating of collagen to 55° C resulted in an increased vWF binding as compared to collagen heated to 37° C or to 90° C. Incubation of collagen with vWF, prior to heating, resulted in a vWF binding after heating to 55° C that was similar to the 37° C binding and a decreased binding after 90° C. Conclusions. After 55° C heating, the von Willebrand factor molecule unfolds and collagen types I and III exhibit an increased adhesiveness for von Willebrand factor. Heating to 90° C denatures von Willebrand factor and collagen. The conformation changes of von Willebrand factor and its altered binding to collagen type I and III may explain the increased and decreased platelet adhesion to subendothelium after 55° C and 90° C heating, respectively.

Fibrinolytic Activity of the Arterial Wall

1969 ◽  
Vol 21 (01) ◽  
pp. 001-011 ◽  
Author(s):  
K Onoyama ◽  
K Tanaka
Keyword(s):  
Carotid Artery ◽  
Fibrinolytic Activity ◽  
Arterial Wall ◽  
Aortic Wall ◽  
Internal Carotid ◽  
Atheromatous Plaque ◽  
Human Fibrinogen ◽  
The Media ◽  
The Common ◽  
Almost All

SummaryThe tissue fibrinolysis was studied in 550 specimens of 7 kinds of arteries from 80 fresh cadavers, using Astrup’s biochemical method and Todd’s histochemical method with human fibrinogen.In the microscopically normal aortic wall, almost all specimens had the fibrinolytic activity which was the strongest in the adventitia and the weakest in the media.The fibrinolytic activity seemed to be localized in the endothelium.The stronger activity lay in the adventitia of the aorta and the pulmonary artery and all layers of the cerebral artery.The activity of the intima and media of the macroscopically normal areas seemed to be stronger in the internal carotid artery than in the common carotid artery.Mean fibrinolytic activity of the macroscopically normal areas seemed to decrease with age in the intima and the media of the thoracic aorta and seemed to be low in the cases with a high atherosclerotic index.The fibrinolytic activities of all three layers of the fibrous thickened aorta seemed to decrease, and those of the media and the adventitia of the atheromatous plaque to increase.The fibrinolytic activity of the arterial wall might play some role in the progress of atherosclerosis.

Mechanism of Lipid Deposition on Arterial Wall

1964 ◽  
Vol 5 (5) ◽  
pp. 397-398
Author(s):  
Mototaka MURAKAMI
Keyword(s):  
Arterial Wall ◽  
Lipid Deposition

ANISOTROPIC TRANSPORT THROUGH POLYMER LAYER AND POROUS ARTERIAL WALL WITH BINDING IN DRUG-ELUTING STENTS USING THE FEM

2018 ◽  
Author(s):  
fabiane aparecida dos santos frazzoli ◽  
Rachel Manhaes de Lucena ◽  
Norberto Mangiavacchi ◽  
José da Rocha Miranda Pontes ◽  
Gustavo Rabello dos Anjos ◽  
...  
Keyword(s):  
Arterial Wall ◽  
Polymer Layer ◽  
Drug Eluting Stents ◽  
Drug Eluting ◽  
Anisotropic Transport

Fibrillar, Fibril-associated and Basement Membrane Collagens of the Arterial Wall: Architecture, Elasticity and Remodeling Under Stress

2015 ◽  
Vol 21 (9) ◽  
pp. 1124-1133 ◽  
Author(s):  
M.S. Osidak ◽  
E.O. Osidak ◽  
M.A. Akhmanova ◽  
S.P. Domogatsky ◽  
A.S. Domogatskaya
Keyword(s):  
Basement Membrane ◽  
Arterial Wall
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