Multipotent Mesenchymal Stromal Cell-Based Therapies: Regeneration Versus Repair

2014 ◽  
pp. 3-16
Author(s):  
Maddalena Caruso ◽  
Ornella Parolini
Keyword(s):  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Multipotent Mesenchymal Stromal Cell

scholarly journals Combination of the multipotent mesenchymal stromal cell transplantation with administration of temozolomide increases survival of rats with experimental glioblastoma

2015 ◽  
Vol 12 (2) ◽  
pp. 2828-2834 ◽  
Author(s):  
IGOR BRYUKHOVETSKIY ◽  
ANDREI BRYUKHOVETSKY ◽  
YURI KHOTIMCHENKO ◽  
POLINA MISCHENKO ◽  
ELENA TOLOK ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Multipotent Mesenchymal Stromal Cell

scholarly journals Hypoxia-Controlled EphA3 Marks a Human Endometrium-Derived Multipotent Mesenchymal Stromal Cell that Supports Vascular Growth

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112106 ◽  
Author(s):  
Catherine To ◽  
Rae H. Farnsworth ◽  
Mary E. Vail ◽  
Chanly Chheang ◽  
Caroline E. Gargett ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Human Endometrium ◽  
Multipotent Mesenchymal Stromal Cell ◽  
Vascular Growth

Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro

Cytotherapy ◽  
2013 ◽  
Vol 15 (12) ◽  
pp. 1469-1483 ◽  
Author(s):  
Sarah Griffiths ◽  
Priya R. Baraniak ◽  
Ian B. Copland ◽  
Robert M. Nerem ◽  
Todd C. McDevitt
Keyword(s):  
Cell Growth ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Human Platelet ◽  
Platelet Lysate ◽  
Multipotent Mesenchymal Stromal Cell ◽  
High Passage ◽  
Human Platelet Lysate

scholarly journals Antimicrobial and Regenerative Effects of Placental Multipotent Mesenchymal Stromal Cell Secretome-Based Chitosan Gel on Infected Burns in Rats

2021 ◽  
Vol 14 (12) ◽  
pp. 1263
Author(s):  
Vasily Kudinov ◽  
Rafael Artyushev ◽  
Irina Zurina ◽  
Roman Lapshin ◽  
Ludmila Snopova ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Cultured Cells ◽  
Skin Wound ◽  
Water Soluble ◽  
Burn Wound ◽  
Multipotent Mesenchymal Stromal Cell ◽  
Burned Areas ◽  
Burn Wound Healing

Background: There is a need for better strategies to promote burn wound healing and prevent infection. The aim of our study was to develop an easy-to-use placental multipotent mesenchymal stromal cell (MMSC) secretome-based chitosan hydrogel (MSC-Ch-gel) and estimate its antimicrobial and regenerative activity in Staphylococcus aureus-infected burn wounds in rats. Methods: Proteomic studies of the MMSC secretome revealed proteins involved in regeneration, angiogenesis, and defence responses. The MMSC secretome was collected from cultured cells and mixed with water-soluble chitosan to prepare the placental MSC-Ch-gel, which was stored in liquid phase at 4 °C. The wounds of rats with established II-IIIa-degree burns were then infected with S. aureus and externally covered with the MSC-Ch-gel. Three additional rat groups were treated with medical Vaseline oil, the antiseptic drug Miramistin®, or the drug Bepanthen® Plus. Skin wound samples were collected 4 and 8 days after burning for further microbiological and histological analysis. Blood samples were also collected for biochemical analysis. Results: Application of the MSC-Ch-gel cleared the wound of microorganisms (S. aureus wasn’t detected in the washings from the burned areas), decreased inflammation, enhanced re-epithelialisation, and promoted the formation of well-vascularised granulation tissue. Conclusions: MSC-Ch-gel effectively promotes infected wound healing in rats with third-degree burns. Gel preparation can be easily implemented into clinical practice.

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