Predicting Antigenicity in Proteins and the Future of Synthetic Peptide Vaccines

1987 ◽  
pp. 227-233
Author(s):  
M. H. V. Van Regenmortel
Keyword(s):  
Synthetic Peptide ◽  
Peptide Vaccines ◽  
The Future

Hepatitis B Surface Antigen Polypeptide and Synthetic Peptide Vaccines

Hepatitis B ◽  
1984 ◽  
pp. 215-224 ◽  
Author(s):  
G. R. Dreesman ◽  
I. Ionescu-Matiu ◽  
Y. Sanchez ◽  
R. C. Kennedy ◽  
J. T. Sparrow ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Synthetic Peptide ◽  
Hepatitis B Surface Antigen ◽  
Peptide Vaccines

scholarly journals Synthetic peptide vaccines

2011 ◽  
Vol 57 (1) ◽  
pp. 14-30 ◽  
Author(s):  
A.A. Moysa ◽  
E.F. Kolesanova
Keyword(s):  
Synthetic Peptide ◽  
High Throughput Screening ◽  
Large Scale ◽  
Peptide Vaccine ◽  
Foot And Mouth Disease ◽  
Transgenic Animals ◽  
Screening Methods ◽  
Peptide Vaccines ◽  
Human Infections ◽  
Selection Of

This review considers the stages of the development of synthetic peptide vaccines against infectious agents, novel approaches and technologies employed in this process, including bioinformatics, genomics, proteomics, large-scale peptide synthesis, high-throughput screening methods, the use of transgenic animals for modelling human infections. An important role for the development and selection of efficient adjuvants for peptide immunogens is noted. Examples of synthetic peptide vaccine developments against three infectious diseases (malaria, hepatitis C, and foot-and-mouth disease) are given.

Synthetic Peptide Vaccines: Success at Last

Vaccines ◽  
1995 ◽  
pp. 127-133 ◽  
Author(s):  
R. H. Meloen ◽  
J. I. Casal ◽  
K. Dalsgaard ◽  
J. P. M. Langeveld
Keyword(s):  
Synthetic Peptide ◽  
Peptide Vaccines

scholarly journals The peptide vaccine of the future

2020 ◽  
pp. mcp.R120.002309
Author(s):  
Annika Nelde ◽  
Hans Georg Rammensee ◽  
Juliane Sarah Walz
Keyword(s):  
Immune Responses ◽  
Target Selection ◽  
Peptide Vaccine ◽  
Predictive Biomarkers ◽  
Peptide Vaccines ◽  
Peptide Vaccination ◽  
Anti Cancer ◽  
The Future ◽  
Clinical Responses ◽  
Review Current

The approach of peptide-based anti-cancer vaccination has proven the ability to induce cancer-specific immune responses in multiple studies for various cancer entities. However, clinical responses remain so far limited to single patients and broad clinical applicability was not achieved. Therefore, further efforts are required to improve peptide vaccination in order to integrate this low side effect therapy into the clinical routine of cancer therapy. To design clinically effective peptide vaccines in the future, different issues have to be addressed and optimized comprising antigen target selection as well as choice of optimal adjuvants and vaccination schedules. Furthermore, the combination of peptide-based vaccines with other immuno- and molecular targeted therapies as well as the development of predictive biomarkers could further improve efficacy. In this review, current approaches in the development of peptide-based vaccines and critical implications for optimal vaccine design are discussed.

Design and development of synthetic peptide vaccines: past, present and future

2007 ◽  
Vol 6 (4) ◽  
pp. 591-603 ◽  
Author(s):  
Martijn S Bijker ◽  
Cornelis JM Melief ◽  
Rienk Offringa ◽  
Sjoerd H van der Burg
Keyword(s):  
Synthetic Peptide ◽  
Peptide Vaccines ◽  
Design And Development

Synthetic peptide vaccines: success at last

Vaccine ◽  
1995 ◽  
Vol 13 (10) ◽  
pp. 885-886 ◽  
Author(s):  
R.H. Meloen ◽  
J.I. Casal ◽  
K. Dalsgaard ◽  
J.P.M. Langeveld
Keyword(s):  
Synthetic Peptide ◽  
Peptide Vaccines
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